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Modulating gut microbiota using nanotechnology to increase anticancer efficacy of the treatments
Abduladheem Turki Jalil,Shahad N. Thabit,Zaman Kareem Hanan,Mohammed Qasim Alasheqi,Abdul Kareem J. Al‑Azzawi,Rahman S. Zabibah,Ali A. Fadhil 한국고분자학회 2023 Macromolecular Research Vol.31 No.8
Recent clinical and pathological evidence has implicated the gut microbiota as an interplay for regulating human body homeostasis, influencing conditions ranging from cancer and dementia to obesity and social behavior. It has the potential to influence cancer prognosis and the results of cancer therapies such as chemotherapy, radiation therapy, and immunotherapy. A growing body of evidence suggests that modulating the gut microbiota can improve the efficacy of anticancer drugs. Nanomedicine has emerged as one of the most promising technologies for modernizing traditional approaches. Accordingly, specific attention has been grabbed toward using nanomaterials to modulate the gut microbiota to enhance the anticancer treatment efficacy. The critical roles of gut microbiota in carcinogenesis, cancer progression, and various cancer therapies are first introduced in this review. Following that, nanomedicine advances that improve cancer therapy efficacy by modulating or engineering gut microbiota are highlighted. Finally, the challenges and opportunities of using nanomedicine to target gut microbiota for cancer prevention and treatment are briefly discussed. Although there are some review papers in this concept, but there are room for further clarification to shed light on the way cross-talk between gut microbiota and cancer and, more specifically, modulating effects and emerging roles of nanomaterials.
Abdalkareem Jasim,Ghassan Fadhil Smaisim,Abduladheem Turki Jalil,Surendar Aravindhan,Abdullah Hasan Jabbar,Shaymaa Abed Hussein,Muneam Hussein Ali,Muataz S. Alhassan,Yasser Fakri Mustafa Techno-Press 2023 Advances in materials research Vol.12 No.4
In this study, AA1060/Alumina composites were fabricated by combined stir casting and accumulative press bonding (APB). The APB process was repeated up to six press bonding steps at 300Ċ. As the novelty, potential dynamic polarization in 3.5Wt% NaCl solution was used to study the corrosion properties of these composites. The corrosion behavior of these samples was compared and studied with that of the annealed aluminum alloy 1060 and versus the number of APB steps. So, as a result of enhancing influence on the number of APB process, this experimental investigation showed a significant enhancement in the main electrochemical parameters and the inert character of the Alumina particles. Together with Reducing the active zones of the material surfaces could delay the corrosion process. Also, at higher number of steps, the corrosion resistance of composites improved. The sample produced after six number of steps had a low corrosion density in comparison with high corrosion density of annealed specimens. Also, the scanning electron microscopy (SEM), was used to study the corrosion surface of samples.
Alim Al Ayub Ahmed,Majid M. Kharnoob,Ravil Akhmadeev,Andrei Sevbitov,Abduladheem Turki Jalil,Mustafa M. Kadhim,Zahra J. Hansh,Yasser Fakri Mustafa,Irina Akhmadullina 국제구조공학회 2022 Structural Engineering and Mechanics, An Int'l Jou Vol.83 No.4
In this paper, the effect of fire conditions according to ISO 834 standard on the behavior of carbon fibre-reinforced plastic (CFRP) reinforced steel beams coated with gypsum-based mortar has been investigated numerically. To study the efficiency of these beams, 3D coupled temperature-displacement finite element analyzes have been conducted. Mechanical and thermal characteristics of three different parts of composite beams, i.e., steel, CFRP plate, and fireproof coating, were considered as a function of temperature. The interaction between steel and CFRP plate has been simulated employing the adhesion model. The effect of temperature, CFRP plate reinforcement, and the fireproof coating thickness on the deformation of the beams have been analyzed. The results showed that within the first 120 min of fire exposure, increasing the thickness of the fireproof coating from 1 mm to 10 mm reduced the maximum temperature of the outer surface of the steel beam from 380°C to 270°C. This increase in the thickness of the fireproof layer decreased the rate of growth in the temperature of the steel beam by approximately 30%. Besides excellent thermal resistance and gypsum-based mortar, the studied fireproof coating method could provide better fire resistance for steel structures and thus can be applied to building materials.