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Effect of Tilliacorine on Haematological and Biochemical Parameters
A. Roychowdhuri,J. Rajan Vedasiromoni,Malaya Gupta,S. K. Mitra,Biswapati Mukherjee,Arnab Khasnobis,Tapan Seal 한국생약학회 2000 Natural Product Sciences Vol.6 No.3
Tiliacora racemosa Colebr. belonging to the family Menispermaceae, is the biggest storehouse of diphenyl bisbenzylisoquinoline (DBBI) alkaloids. Exhaustive chemical processing of the root of T. racemosa by the application of modern separation techniques yielded a DBBI alkaloid which was identified as tiliacorine using sophisticated spectroscopic methods (UV, IR, ¹H-NMR, MS). Haematological study with tiliacorine proved that there was no abnormal haematological results in comparison with the normal values. Chronic toxicity study with tiliacorine revealed that the alkaloid is devoid of any hepatotoxic and nephrotoxic action.