화농성 견관절염의 관절경적 처치

문영래,유재원,심형준,박준광 조선대학교 부설 의학연구소 2002 The Medical Journal of Chosun University Vol.27 No.1

Purpose : The purpose of this study is to evaluate the usefulness of arthroscopic drainage in the management of septic arthritis of the shoulder. Materials and methods : The cases of nine septic glenohumeral joints were evaluated. Each patient was treated by arthroscopic irrigation and necrotic synovectomy, combined with parenteral antibiotics. Result In five of nine shoulders in which treatment was begun four weeks or less after symptoms appeared, a satisfactory functional outcome was obtained, while four patients who were treated after a delay of more than four weeks had poor results. Conclusion : The most significant factors leading to poor results of treatment were delay in instituting treatment, virulence of the infecting organism, and a serious process of underlying disease. Arthroscopic drainage is a valuable procedure for the treatment of the septic arthritis of shoulder. Arthroscopic drainage is a method that has proved effective, with minimal morbidity, in attempts to cure septic arthritis of the shoulder.

슬관절 반월상 연골 낭종의 관절경척 치료

문영래 朝鮮大學校 附設 醫學硏究所 2009 The Medical Journal of Chosun University Vol.34 No.1

Background and Purpose: Decompression and Landsiedl outside to inside technique for meniscal cysts didn't need the special device, could allow both horizontal and vertical suture, also provided secure and safe method for posterior horn repair and reduce the recurrence rate. The purpose of this study is to evaluate arthroscopic repair of meniscal cyst by Landsiedl technique. Material and methods: We chose 8 cases of meniscal cysts, whose ages ranged from 16 from 49 years old. We performed meniscal closure and evaluate the result by Glasgow scale and clinical findings. Results: Two patient revealed excellent and 6 showed good result by Glasgow measurement scale. Conclusion: Cyst decompression and Landsiedl outside to inside technique considered one of the satisfactory methods for the treatment of meniscal cyst.

회전근 개 파열 관절중에서 시행한 역구형 관절 치환술 : 2례 보고

문영래,이상홍,노경환 朝鮮大學校 附設 醫學硏究所 2009 The Medical Journal of Chosun University Vol.34 No.1

경골 과부 골절에 대한 관절경하 탐색자를 이용한 정복방법

문영래,김근호 조선대학교 2003 The Medical Journal of Chosun University Vol.28 No.1

Purposes : To evaluate the result and technique of arthroscopic reduction with probe for Intraarticular fracture of the tibial condyles. Materials and Methods : From October 1998 through January 2000, 15 patients were treated for Intraarticular tibial condylar fracture. Average follow up were 22 months, with a range of 13 to 46 months According to Schatzker classification,3 cases were classified as pure cleavage(type Ⅰ),8 cases of cleavage with depression(type Ⅱ) and 4 cases of pure central depression(type Ⅲ) For accurate reduction, we used probe to elevate the depressed fracture fragment. Results : The results were obtained from 15 patients who had been Intraarticular tibial condylar fracture and Judged by Porter's criteria Eleven cases revealed more than good results. Conclusion : Intraarticular reduction method for tibial condyle fractures had several advantage such as providing accurate reduction, preventing cartilage perforation and easy to perform.

복강 내 체액의 Cytokine 농도를 이용한 난소암과 양성난소질환의 감별진단

양선문,송경은,서장수,조영래 대한임상병리학회 2000 대한임상병리학회지 Vol.20 No.6

白花蛇舌草 메탄올 抽出物의 抗腫瘍 效果 및 抗癌 棋戰에 關한 硏究

魯勳政,文九,文錫哉,元秦熹,文永昊,朴來佶 대한한방종양학회 2000 대한한방종양학회지 Vol.6 No.1

Objectives: This experimental study was carried out to evaluate the effects of aqueous and methanol extracts of Hedyotis diffusa which has long been used for cancer treatment in oriental medicines on the induction of apoptotic cell death in human lymphoid leukemia cell line, HL-60. Methods: Cells were treated with various concentrations (200 to 0.4㎍) and periods (6 to 30 hr) of H_2O and methanol extracts of Hedyotis diffusa. Then, cells were tested for viability by MTT assay. Cells wrere treated with 200㎍/ml of methanol extract fork various periods. Genomic DNA was isolated, separated, on 1.5% agarose gels, stained with ethidium bromide and visualized under UV light. Cells were treated with 200㎍/ml of each extract for 16hr.Then, cells were treated with various doses of each extract for 12 hr and 100㎍/ml of methanol extract for various periods. Lysate from the cells used to measure the activity of caspase-1 and-3 proteases by using fluorogenic peptide substrates including acetyl-YVAD-AMC and acetyl-DEVD-AMC, respectively, Cells were treated with 200㎍/ml of each extract for various periods. Cell lysates were immunoprecipated with anti-JNKl antibodies. The immune complex was reacted with 32^p-ATP and c-Jun as a substrate. The phosphotransferase activity of JNKI was measured by suing Phosphoimage analyzer (Fuji Co., Japan). Nuclear extracts were isolated and incubated with oligonucleotide probe of NF-kB was measured by using EMSA and visualized by PhosphoImage analyzer (Fuji Co, Japan). Cell lysates were prepared and analyzed by Western blotting with anti-Bc12 antibodies and anti-Bax antibodies. Cells were pretreated with various doses of methanol extract for 2 hr. Then, the extract was removed by centrifugation. Cells were resuspended with RPMI-1640 media containing 0.3% agarose, 10% FBS, overlayred onto bottom layer agarose and incubated at CO_2 incubator for 6 days. The number of colony was cunted under light microscopy (×100). Results: The death of HL_60 cells was markedly induced by the addition of methanol extract of Hedyotis diffusa in a dose and time-dependent manners. The apoptotic characteristic ladder pattern of DNA strand break was observed in death of HL_60 cells. In addition, it was shown nucleus chromatin condensation under Hoechst staining. Therefore, Hedyotis diffusa extract-induced death of HL-60 cells is mediated by apoptotic signaling processes. The activity of Caspaxe 3-like proteases remained in a basal level in HL-60 cells treated with aqueous extract of Hedyotis diffusa. However, it was markedly increased in HL-60 cells treated with methanol extract of Hedyotis diffusa. In addition, the phosphotransferase activity of JNKl was increased in HL-60 cells treated with methanol extract of Hedyotis diffusa. Furthermore, the activation of transcriptional activator, NF-kB was markedly induced by methanol extract of Hedyotis diffusa. Anti-apoptotic Bc12 was cleaved into 23Kda fragment by treatment of methanol extract of Hedyotis diffusa. However, expression of proapoptotic Bax protein was increased by treatment of methanol extract of Hedyotis diffusa in a time-dependent manner. Furthermore, methanol extract markedly inhibited the colony forming efficiency of HL-60 cells in semisolid agar culture. Conclusions: Above results suggest that methanol extract of Hedyotis diffusa induces the apoptotic death of human leukemic HL-60 cells via activations of Caspase-3 proteases, JNKI, transcriptional activator NF-κB, In addition, our results also suggest that methanol exthanol extract of Hedyotis diffusa reduces the malignant potential of HL-60 cells via down regulation of colony forming effciency through cleavage of Bc12 as well as induction of Bax.

슬개골 연골 연화증 환자에서 시행한 관절경하 외측지대 절개술

선재영,한재석,문영래,김광 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Purpose : The purpose of this study is to evaluate the usefulness of arthroscopic lateral release in the management of chondromalacia patellae. Materials and Methods : The subjects were 48 patients ranging from 36 to 61 years of age. All patients were diagnosed to have chondromalacia patellae by physical examination. Arthroscopic lateral retinacular release of the knee has been performed on the patients under supine position. The results were reviewed at one year and three years after operation. Results : Of those who had grade I chondromalacia, 83.3% had a good at one year and by three years 75% were still good. Although grade III had 63.6%, the number of good results dropped to 36% by three years. Conclusion : Arthroscopy lateral retinacular release is effective for a correct classification of cartilaginous lesions, and it has a useful role to play in the management of early stage chondromalacia patellae.

견봉하 공간의 3차원적 볼륨 분석

Young Lae Moon,Boseon Kim,Moustafa I. Elsayed 대한견주관절의학회 2014 대한견주관절학회 학술대회논문집 Vol.2014 No.3

Ultrasound-guided Therapeutic Interventions around the Shoulder

Moon, Young Lae,Venkat Gorthi 朝鮮大學校 附設 醫學硏究所 2009 The Medical Journal of Chosun University Vol.34 No.2

A number of interventional procedures such as arthrocentesis (aspiration of joint fluid), drainage of soft-tissue collections, steroid injections, tumor biopsy, removal of foreign bodies, and administration of regional anesthesia are nowadays being routinely performed percutaneously under the sonographic guidance. The ultrasound sound has replaced the conventional blind and fluoroscopic interventional techniques when performing such procedures as it is more accurate, allows real time evaluation and is also free from the radiation hazards to both the patients and the medical personnel. A series of procedures around the shoulder joint such as, injecting therapeutic agents into subacromial bursa, rotator cuff tendons, biceps tendon, acromioclavicular joint and percutaneous treatment of calcifying tendinitis, which are safe and reasonably simple to perform in the outpatient setting under the sonographic guidance will be briefly described in this article. The purpose of these procedures is to drain out inflammatory fluid collections and / or to inject therapeutic agents to control inflammation and promote healing.

The Primary Reverse Total Shoulder Arthroplasty for Post-septic Destroyed Shoulder

Young Lae Moon(문영래),Ki Young Nam(남기영),Sueng Hwan Jo(조승환),Gorthi Venkat 대한견주관절의학회 2009 대한견주관절의학회지 Vol.12 No.2

목적: 71세 여자에서 견관절 감염 후 발생된 관절연골의 파괴와 회전근 개의 소실에 대한 처치를 보고하고자 한다. 대상 및 방법: 치료를 선택 전 임상적, 방사선학적, 실험실적으로 세심한 평가를 시행하여 현재 잔존할 수 있는 활동성 감염과 병소의 가능성을 배제한 후 통증과 기능적 관절운동을 회복하기 위하여 일차적 역 견관절 치환술을 시행하였다. 결과: 수술 22개월후 추시에서 UCLA, ASES 평가상 우수의 결과를 얻을 수 있었다. 결론: 감염후 심각한 회전근개의 손상이 동반되는 경우 일차적 역 견관절 치환술은 통증과 기능적 관절운동을 회복할 수 있는 술식으로 보인다. Purpose: We report here on a solution for the case of a 71 year old lady with cartilage destruction in the left shoulder and the loss of the rotator cuff secondary to post-septic arthritic sequelae. Materials and methods: After thorough laboratory, clinical and radiological investigation of the patient to rule out any foci of active infection, we contemplated performing reverse total shoulder arthroplasty as a primary procedure. Results: At 22 months follow up, the patient had an excellent result according to the UCLA and ASES scales. Conclusion: Reverse total shoulder arthroplasty seems to be an efficient procedure to improve pain and function in the post-septic shoulder accompanying severe rotator cuff injury.