메타콜린을 이용한 기도 과민반응과 체성분과의 관계

진현정 ( Hyun Jung Jin ),신경철 ( Kyeong Cheol Shin ),정진홍 ( Jin Hong Chung ),이관호 ( Kwan Ho Lee ) 대한결핵 및 호흡기학회 2011 Tuberculosis and Respiratory Diseases Vol.70 No.3

Background: The rising prevalence of asthma may be associated with the rising prevalence of obesity in developed nations. There are several studies showing that obesity increases the risk of asthma in adults. We investigated the association of each body composition scale and bronchial hyper-responsiveness. Methods: This study involved a retrospective review of the existing records for 279 subjects with respiratory symptoms, who underwent a pulmonary function test, a methacholine challenge test and a body composition test between May 2007 and June 2009. Results: Of the 279 subjects, 179 (64%) were female. There was a statistically significant difference in fat free mass and in fat free mass index between the normal bronchial responsiveness group and bronchial hyper-responsiveness group (p=0.036; p=0.000). There was no significant differences in body mass index, in fat mass and fat free mass index in the normal bronchial responsiveness group and bronchial hyper-responsiveness group in males. However in females, body mass index and fat free mass index were increased in the bronchial hyper-responsiveness group (p=0.044; p=0.000). Total body water (kg), fat free mass (kg) and soft lean mass (kg) were significantly different between the normal bronchial responsiveness group and bronchial hyper-responsiveness group (p=0.002; p=0.000; p=0.000). Conclusion: This study showed significant differences in fat free mass and in fat free mass index between the normal bronchial responsiveness group and the bronchial hyper-responsiveness group. In females, BMI, soft lean mass, and total body water showed significant differences between the normal bronchial responsiveness group and the bronchial hyper-responsiveness group. We concluded that bronchial hyper-responsiveness was associated with not only body mass index but also fat free mass index in female bronchial asthma.

폐쇄성폐질환에서 우울증상의 빈도 및 위험 인자

진현정 ( Hyun Jung Chin ),이관호 ( Kwan Ho Lee ),박찬서 ( Chan Soh Park ),손창우 ( Chang Woo Son ),이하영 ( Hi Young Lee ),유성근 ( Sung Ken Yu ),신경철 ( Kyeong Cheol Shin ),정진홍 ( Jin Hong Chung ),김정엽 ( Jung Youp Kim ) 대한결핵 및 호흡기학회 2008 Tuberculosis and Respiratory Diseases Vol.65 No.3

연구배경: 만성폐쇄성폐질환에서 점진적인 폐기능의 악화 및 치료의 장기화는 환자의 삶의 질을 저하시키며 우울증의 발생 가능성을 높인다. 만성폐쇄성폐질환에서 우울증의 빈도, 호흡기 증상과 관련된 삶의 질 정도와 우울증과의 관계 및 관련 인자에 관해 알아보았다. 방법: 대상은 2007년 3월부터 9월까지 영남대학교 의료원 호흡기내과 외래를 방문한 59명의 만성폐쇄성폐질환 환자로 하였으며, 이들에서 폐기능 검사 및 해당 설문조사를 시행하였다. 호흡기 증상과 관련된 삶의 질에 대한 평가는 SGRQ (St. George`s Respiratory Questionnaire), 우울증은 우울척도인 CES-D (Center for Epidermiological Studies-Depression Scale)를 사용하였다. 결과: 연구 결과 만성폐쇄성폐질환자에서 우울증의 유병율은 17.0%로 일반인들의 우울증 유병률보다 높았다. SGRQ 결과 증상, 활동 제한, 영향력 제한, 총 점수 모두 우울증상과 양의 상관관계를 보였다(p=0.010, 0.001, 0.000, 0.046). 폐기능 검사에서 FEV1은 SGRQ 및 우울증상과 음의 상관관계를 보였다(p=0.001, 0.000, 0.000, 0.002, 0.006). 만성폐쇄성폐질환 환자에서 생활수준이 낮을수록 우울증상은 증가하였고 삶의 질도 저하되었으나 교육 수준, 신뢰도 정도 등과는 통계적으로 유의한 차이가 없었다. 결론: 만성폐쇄성폐질환 환자는 일반인들에 비해 우울증의 유병률이 높았으며 우울증상에 관여하는 의미있는 인자는 폐기능의 감소와 경제적 수준이었다. Background: Due to the irreversible nature of chronic obstructive pulmonary disease (COPD), the treatment aim in patients with COPD is not to cure but to reduce the symptoms, increase lung function, and improve the quality of life. It has been suggested that depression is a common emotional disturbance in patients with COPD who are faced with a major physical impairment and embarrassing symptoms. This study evaluated the prevalence and risk factors of depression in patients with chronic obstructive pulmonary disease. Methods: A total of 59 patients with a registered diagnosis of chronic obstructive pulmonary disease were selected. Depression was assessed using the Centers for Epidemiologic Studies Depression (CES-D) scale. The quality of life was assessed using the Korean version of the St. George`s Respiratory Questionnaire. Results: The prevalence of depression was 17.0%. In the correlation model, the interaction of the FEV1% over predicted value and SGRQ score(symptom, activity, impact, overall score) was statistically significant. The interaction of the FEV1% over predicted value and depression scale(CES-D) was also statistically significant. There was a positive correlation between the SGRQ scores(symptom, activity, impact, overall score) and the depression scale. Conclusion: The prevalence of depression in patients with chronic obstructive pulmonary disease is relatively high. The pulmonary function and the living standards were found to be significant risk factors for depression.

미강 식이섬유 첨가량이 흰쥐의 혈청지질농도, 장 기능 및 무기질 흡수율에 미치는 영향

진현정 ( Hyun Jung Jin ),이상선 ( Sang Sun Lee ) 한국식품영양학회 2011 韓國食品營養學會誌 Vol.24 No.4

This study was performed to investigate the effect of rice bran dietary fiber powder on serum lipid levels, bowel function, and mineral absorption in rats. Four weeks old male Sprague Dawley rats(SD rat) were divided into four groups : control group fed 5% cellulose as a fiber source, RB10 fed 5% of cellulose and 10% of rice bran dietary fiber powder, RB20 and RB30. The animals were fed the experimental diets for 4 weeks. Serum lipid levels were not significantly different among the groups. But, fecal total cholesterol(TC), triglycerides(TG), and high density lipoprotein cholesterol(HDL-c) excretion increased in the RB30 group. Fecal weight and fecal water content were higher in the rice bran added groups than those in the control group. Transit time was significantly shorter in the rice bran fiber-added groups than that in the control. Weight of the stomach and large intestine in the RB20 and RB30 groups were significantly greater than those in the other groups. Absorption rates of Ca, Mg, P, and Zn decreased significantly in the RB30 group compared to those in the other groups. A high amount of rice bran increased fecal lipids, including TC, TG and HDL-c. Rice bran increased fecal weight and fecal water content and shortened gastrointestinal transit time. However, a high level of rice bran diet decreased mineral absorption rates.

성인 집먼지진드기 알레르기 환자에서 특이 IgE 결합 성분 항원 비교

진현정 ( Hyun Jung Jin ),윤문경 ( Moon-gyung Yoon ),남영희 ( Young-hee Nam ),안준홍 ( June Hong Ahn ),박해심 ( Hae-sim Park ),정진홍 ( Jin Hong Chung ) 대한천식알레르기학회(구 대한알레르기학회) 2016 Allergy Asthma & Respiratory Disease Vol.4 No.3

Purpose: This study investigated the differences in the profile of IgE-binding components between Dermatophagoides pteronyssinus (Dp) and Dermatophagoides farina (Df) in respiratory allergic patients sensitized to Dp/Df. Methods: Eighteen patients with respiratory allergic diseases having higher levels of serum specific IgE to Df compared to those to Dp (>twice) were enrolled. IgE-immunoblot analysis using Dp and Df extracts were used to compare the IgE binding components. Study subjects were classified into 2 groups according to the results of IgE-immunoblot analysis: 6 subjects having IgE-binding components to group 1 and 2 allergens (group B) and 12 subjects not having them (group A). Results: Group A subjects were older (47.92±8.51 vs. 35.50±11.10, P=0.039) and males were dominant (75% vs. 0% P=0.009). IgE-immunoblot analysis demonstrated that all the group B subjects had IgE bindings to 2 major components, 14 and 25 kDa, while group A subjects had IgE bindings to high-molecular weight components ranging from 60.98 kDa. The enzyme-linked immunosorbent assay inhibition test showed a significant inhibition with additions of Df, not with Dp in group B subjects. Serum specific IgE levels to Dp and Df were significantly higher in group B than in group A, while its ratio (Df to Dp) was significantly higher in group A. No differences were noted in clinical parameters, total IgE, or eosinophil cationic protein levels. Conclusion: Heterogeneity of IgE binding patterns to Dp and Df extracts was noted according to the ratio of serum specific IgE (Df/Dp). (Allergy Asthma Respir Dis 2016;4:199-204)

아나필락시스: 진단, 치료, 개선점

진현정 ( Hyun Jung Jin ) 대한천식알레르기학회(구 대한알레르기학회) 2016 Allergy Asthma & Respiratory Disease Vol.4 No.2

성인 육류알레르기 환자에서 성분항원 특이 IgE 항체의 진단적 의의

진현정 ( Hyun Jung Jin ),김주희 ( Joo Hee Kim ),남영희 ( Young Hee Nam ),황의경 ( Eui Kyung Hwang ),신유섭 ( Yoo Seob Shin ),예영민 ( Young Min Ye ),박해심 ( Hae Sim Park ) 대한천식알레르기학회 2011 천식 및 알레르기 Vol.31 No.4

Background: Bovine serum albumin (BSA) and swine serum albumin (SSA) have been known as major allergens in beef and pork allergies. The aims of this study were to assess the diagnostic values of specific IgE antibodies to BSA and SSA and to evaluate predictive values for cross-reactivities in patients with adult meat allergy. Methods: Twenty-one adult patients with meat allergy and 15 healthy controls were enrolled for this study. Serum specific IgE to beef, pork, milk, BSA and SSA was measured by using immunoCAP (Phadia, Uppsala, Sweden). Patients were divided into 3 groups: those sensitive to beef (group I, n=4), those sensitive to pork (group II, n=10), and those sensitive to beef and pork (group III, n=7). Results: There were no significant differences in sex and manifestations to meat between the 3 groups, whereas age was significantly lower and the total IgE level was significantly higher in group III. The serum levels of specific IgE to BSA and SSA were significantly higher in the 3 groups than in the control group. The sensitivities of specific IgE levels to BSA and SSA, as assessed using receiver operating characteristic analysis, were 36.4% and 52.9%, with specificities being 100% for each. Conclusion: The results of this study suggest that the levels of specific IgE to BSA and SSA may have low sensitivities for the diagnosis of meat allergy and the evaluation of cross-reactivities between meat allergens. (Korean J Asthma Allergy Clin Immunol 2011;31:281-287)

고등학생의 현미경 관찰 활동에 대한 결과 보고 오류 유형 분석틀의 고안 및 오류 유형 분석

진현정 ( Hyun Jung Jin ),이일선 ( Il Sun Lee ),권용주 ( Yong Ju Kwon ) 경북대학교 과학교육연구소 2011 科學敎育硏究誌 Vol.35 No.2

The purpose of this study is to develop the analysis frame of reporting observation results by high school students in biology experiments using microscopes and analyze their error types. For this study, five experiments were carried out by 12 high school students in B metropolitan city. Before these experiments, developed the analysis frame of reporting observation results. Tests for checking prior knowledge of students were done and results of each experiment were taken picture of. Using the developed framework, the real results and reported results submitted by students were analyzed. The result of this study shows how students report their observation results and they tend to have difficulty in doing observation activity itself. The ratio of factual reports is low because observation ways and recording ways have not been taught properly. Observation training is needed for observing real results objectively. The improvement in experiment environment is necessary for right observation, not observation for checking based on only results. In addition, the education of ethics in science research focusing on the integrity should be performed. The analysis data of reporting observation result by students can be used as basic data for teachers to plan observation strategies and to have right observation views and ways.

신체만족도와 정숙성이 초등 예비교사들의 노출패션 착용에 미치는 영향

진현정(Jin Hyun Jeong),정미경(Chung Mee kyung),최경은(Choi Kyeong Eun),정지윤(Jung Ji Yoon) 한국실과교육학회 2013 한국실과교육학회지 Vol.26 No.4

본 연구는 초등 예비 여교사 276명을 대상으로 노출 패션 착용 실태를 조사하고, 정숙성과 신체만족도가 노출 패션 착용에 미치는 영향을 분석하였다. 수집된 자료는 기술통계, 신뢰도 분석, 요인분석, 분산분석, 회귀분석을 통해 분석하였으며, 그 결과는 다음과 같다. 첫째, 초등 예비교사들은 전반적으로 자신의 신체에 만족하지 않으며 신체부위별 만족도는 학년에 따라 유의한 차이가 없는 것으로 나타났다. 전반적으로 노출을 많이 하지 않으나 노출 패션 중다리가 노출된 의복을 비교적 많이 착용하고, 배꼽을 노출하는 옷의 착용을 가장 꺼려하는 것으로 나타났다. 둘째, 정숙성의 하위차원은 시선 거부, 보수성, 타인 배려, 사회적 적합성으로 나타났다. 정숙성의 하위차원이 노출 패션 착용에 미치는 영향을 고찰한 결과 정숙성의 하위차원 중 보수성이 노출패션 착용에 가장 부적으로 영향을 미치는 것으로 나타났다. 신체만족도가 노출 패션 착용에 미치는 영향은 키에 대한 만족도가 뺴꼽이 드러나는 상의 착용에 부적인 영향을 미치고, 실루엣과 자세에 대한 만족도가 몸의 윤곽이 드러나는 옷의 착용에 정적인 영향을 미치는 것으로 나타났다. 셋째, 신체만족도를 체형 만족과 얼굴 만족 요인으로 구분한 후 만족하는 집단과 만족하지 못하는 집단으로 유형화하여 노출 패션 착용의 차이를 고찰한 결과 체형에 만족하는 집단이 체형에 불만족하는 집단보다 다양한 노출 패션을 착용하는 것으로 나타났다. 얼굴에 만족하는 집단은 신체윤곽이 드러나는 옷을 착용하는 것으로 나타났다. This study examines the actual practice of wearing revealing clothes and the effects of modesty and body satisfaction on doing so. Data were obtained from 276 female pre-service elementary school teachers. Collected data were analyzed through descriptive statistics, reliability analysis, factor analysis, ANOVA, and regression analysis. The results of this study are given below. First, it was found that pre-service elementary school teachers were mostly unsatisfied with their bodies and no grade differences were detected in body satisfaction. Subjects mainly tended to wear mini skirts and shorts; they tended not to wear clothes that revealed their navel among five categories of revealing clothing. Second, it was found that modesty consisted of the following four factors: avoidance of others attention, conservativeness, consideration of others, and social appropriateness. The conservativeness factor had the most significant negative effect on wearing revealing clothes. Satisfaction with height had a significant negative effect on wearing clothes that reveal the navel, whereas satisfaction with body silhouette and posture has a significant positive effect on wearing body-conscious clothing. Third, after segmenting body satisfaction into two factors(body satisfaction and face satisfaction) through factor analysis, the respondents were divided into a satisfied group and non-satisfied group based on body and face satisfaction factors. The body-satisfied group was found to wear more revealing clothes of various types than the non-satisfied group.

소비자의 소셜쇼핑 구매결정에 영향을 미치는 요인 분석

진현정(Hyun-Joung Jin),고범석(Beom-Seok Ko),이정희(Jung-Hee Lee) 국제e-비즈니스학회 2012 e-비즈니스 연구 Vol.13 No.2

1999년, 2005년, 2008년 피부반응검사 분석을 통해 본 지난 10년간 경기남부지역 대학병원에 내원한 알레르기 환자의 화분 알레르겐 감작률의 변화

이진우 ( Jin Woo Lee ),최길순 ( Gil Soon Choi ),김정은 ( Jung En Kim ),진현정 ( Hyun Jung Jin ),김주희 ( Joo Hee Kim ),예영민 ( Young Min Ye ),남동호 ( Dong Ho Nahm ),박해심 ( Hae Sim Park ) 대한천식알레르기학회 2011 천식 및 알레르기 Vol.31 No.1

Background: Pollen is a typical outdoor allergen, which is known as a major factor causing respiratory allergic diseases. Objective: This study was designed to observe changes in the sensitization rate to pollen allergens and their characteristics in the southern part of Gyeonggi Province over the last 10 years. Method: Targeting 7,103 patients in total, the results of allergy skin prick tests were obtained in 1999, 2005 and 2008. We assessed changes in skin reactivity to 13 major inhalant allergens, including alder, oak and beech, that cause pollinosis in spring as well as mugwort, ragweed and Hop J pollens that cause pollinosis in autumn, based on the rates of allergen/histamine wheal responses. Higher ratios than 1 were regarded as positive results. Result: The sensitization rates to tree pollens were increased gradually in 1999, 2005 and 2008. The sensitization rates to alder were 5.5% in 1999, 6.2%in 2005 and 9% in 2008 those to oak were 6.7% in 1999, 8.5% in 2005 and 9.6% in 2008. Also, the sensitization rates to weed pollens were increased gradually in 1999, 2005 and 2008 as well. The sensitization rates to mugwort were 11.3% in 1999, 13.1% in 2005 and 15.2% in 2008; those to Hop J were 7.1% in 1999, 8.0% in 2005 and 9.6% in 2008. Especially in cases of Hop J, the proportion of patients with high rates (more than 5+) tended to increase from 27.5% in 1999 to 31.3% in 2005 and 36.9% in 2008. The time point where the sensitization rate started to obviously increase was advanced from September to July, which implies the extension of the sensitization period. Conclusion: The sensitization rates to tree and weed pollens have increased significantly in the southern part of Gyeonggi Province over the last 10 years, which has been noted among the patients at different ages, especially young children and adults over their 40s. An increase in the degree of skin reactivity and the extension of the sensitization period were observed in cases of Hop J. (Korean J Asthma Allergy Clin Immunol 2011;31:33-40)