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관절1호방이 Collagen Ⅱ로 유발된 관절염 억제에 관한 연구
한규진 ( Kyu Jin Han ),진광선 ( Kwang Seon Jin ),신혜란 ( Hye Ran Shin ),윤일지 ( Il Ji Yoon ),최승훈 ( Seung Hoon Choi ),오민석 ( Min Seok Oh ) 한방재활의학과학회 2005 한방재활의학과학회지 Vol.15 No.4
Objectives : The aim of this study was to know the immunity responses of Gwanjulbang-1(Quanjiefang-1)(hereinafter referred to GJB-1) to on Rheumatoid Arthritis in Collagen-induced Arthritis(CIA) Mice Methods : For this purpose, experiments were performed to measure the cytotoxicity against mLFC, hFLSs and the production of proinflammatory cytokines IL-1β, IL-6, TNF-α, IFN-γ in hFLSs and the production of pro-inflammatory cytokines IL-4, IL-10 and the value of CD3+(T), CD19+(B), CD3+/CD69+, CD4, γδ T cells, CD4+/CD25+ Results : 1. The cytotoxicity against mLFC, hFLSs were not measured. 2. The production of pro-inflammatory cytokines IFN-γ were reduced in hFLSs. 3. The production of pro-inflammatory cytokines IL-4, IL-10 were increased. 4. Statistically significant value of CD3+(T), CD19+(B), CD3+/CD69+, CD4, γδ T cells, CD4+/CD25+ compared with control group, wild type, MTX. Conclusions : Comparison of the results for this study showed that GJB-1 had immunomodulatory effects of suppressing or enhancing. So we expect that GJB-1 should be used as a effective drugs for not only rheumatoid arthritis but also another auto-immune disease. Therefore we have to survey continuously in looking for the effective substance and mechanism in the future.
송영일 ( Young Il Song ),진광선 ( Kwang Seon Jin ),신혜란 ( Hye Lan Shin ),윤일지 ( Il Ji Yoon ),최승훈 ( Seung Hoon Choi ),오민석 ( Min Suck Oh ) 한방재활의학과학회 2005 한방재활의학과학회지 Vol.15 No.2
Objectives : This study was designed to find out the characteristic of patients who had admitted due to traffic accident and to promote the superiority of oriental medical treatment on the sequelae of traffic accident. Methods : We analyzed 332 traffic accident patients statistically according to medical charts, who had been hospitalized from January 1, 2000 to October 30, 2004. Results and Conclusions : The analysis showed that there was no significant difference in sex(p>0.05), but the older group and the shorter group of interval time from onset to addmission had the better remedial result(p<0.05). The most common diagnosis that had the better remedial result was lumbar sprain, followed by multiple contusion, cervical sprain, herniated lumbar disc, herniated cervical disc(p<0.05), and the most effective oriental medical treatment was moxibusition, followed by blood cupping therapy, taping therapy, chuna therapy except acupuncture, herbal medication, oriental physical therapy(p<0.05). In using of TENS, ICT, U/S, complex therapy had better remedial result than single therapy(p<0.05). The longer period of treatment group had better remedial result generally(p<0.05).
자락요법(刺絡療法)을 시행한 급성 통풍성 관절염 환자 3례
신혜란 ( Hye Lan Shin ),진광선 ( Kwang Seon Jin ),송영일 ( Young Il Song ),홍서영 ( Seo Young Hong ),윤일지 ( Il Ji Yoon ),오민석 ( Min Suck Oh ) 한방재활의학과학회 2005 한방재활의학과학회지 Vol.15 No.4
Gout is a metabolic disease that occurs on the basis of abnormal metabolism of purines and compounds. It is characterized by hyperuricemia, recurrent attacks of acute arthritis, deposition of monosodium urate crystais in and around the joints of the extremities, urolithiasis renal and cardiovascular disease. We treated three acute goupty arthritis patients who had severe pain, swelling and redness et al. All patients were treated with Bloodletting and Sopungwhalhyel-tang(Xiaofenghuoxie-tang). Bloodletting were treated on acu-point of complex Palpung(Bafeng) and Hyenjong(Xuanzhong) point. In the all case, symptoms(pain, swelling and redness et al) had been improved. According to the above result, it is possibly suggested that bloodletting had a therapeutic effect on recovery of acute gouty arthritis.
신선기보탕(神仙氣步湯)이 Collagen Ⅱ 유발관절염(誘發關節炎)의 발생 및 치료에 미치는 영향
구본길 ( Bon Kil Koo ),신혜란 ( Hye Lan Shin ),진광선 ( Kwang Seon Jin ),윤일지 ( Il Ji Yoon ),오민석 ( Min Suck Oh ) 한방재활의학과학회 2005 한방재활의학과학회지 Vol.15 No.4
Objectives: Cytokines play key roles in spontaneous autoimmune arthritis in CIA(collagen induced arthritis) mice, a model of rheumatoid arthritis. The object of study is to evaluate the effect of IL-6, TNF-α on development of collagen induced arthritis, on humoral and cellular immunity and on the endogenous production of IL-6, TNF-α in DBA/1J mice. Methods: DBA/1J mice were immunized with 100㎍ bovine type II collagen in 0.1㎖ Freund`s complete adjuvant. There are three groups in this study, Which are wild type(WT), CIA-control and CIA-SSKBT(350㎎/㎏). Levels of anti-collagen antibodies, serum IL-6 and TNF-α were measured at the end of study. At week 6, CIA-control group developed arthritis while CIA-SSKBT group showed far less incidence and severity of arthritis. Result and Conclusions: This study shows that SSKBT inhibits inflammatory effect of IL-6, TNF-α.
교통사고로 인한 Barr -Li ou Syndrome 환자 1례에 대한 임상적 고찰
송영일 ( Young Il Song ),민부기 ( Boo Ki Min ),진광선 ( Kwang Seon Jin ),신혜란 ( Hye Lan Shin ),김종국 ( Jong Kook Kim ),송인선 ( In Sun Song ),윤일지 ( Il Ji Yoon ),최승훈 ( Seung Hoon Choi ),오민석 ( Min Suck Oh ) 한방재활의학과학회 2004 한방재활의학과학회지 Vol.14 No.3
Objectives: There are a few case reports on the treatment of the Barre-Lieou Syndrome by oriental medicine. We got a good effect on one patient with Barre-Lieou Syndrome by oriental medicine. Methods: The patient was hospitalized Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Dae-jeon University from 2nd, Feb. 2004 to 2nd, Mar. 2004, diagnosed as Stagnation of qi and stasis of blood(氣滯血瘀), deficiency of qi and blood(氣血虧虛), and treated with Acupuncture therapy, Herbal medication, Chuna therapy, Bee Venom Acupuncture, Oriental physical therapy. Results & Conclusions: Symptoms of the patient such as neck pain, dizziness, tinnitus, fatigue, etc were improved after above treatments. So, it is suggested that oriental medical treatments are effective in the Barre-Lieou Syndrome.
김종국 ( Jong Kook Kim ),송인선 ( In Sun Song ),신혜란 ( Hye Lan Shin ),진광선 ( Kwang Seon Jin ),윤일지 ( Il Ji Yoon ),최승훈 ( Seung Hoon Choi ),오민석 ( Min Suck Oh ) 한방재활의학과학회 2004 한방재활의학과학회지 Vol.14 No.1
Objective: The aim of this study was to investigate the effects of absolute bed resting(ABR) period on bone mineral density(BMD) recovery in acute stroke patients. It is necessary for acute stroke patients to spend a few days-absolute bed resting period-for treatment. During ABR period, bone mineral density have a tendency to decrease. But During exercise period, BMD have a tendency to increase. Therefore this clinical study investigate the change of BMD in acute stroke patients. Methods: This clinical study have been carried out with 50 cases of acute stroke patients that entered Cheongju Oriental Hospital from March to October 2003 and investigates through several items-diagnosis, sex, age, ABR period, smoking, drinking, hypertension, diabetes mellitus(DM) and osteoporosis. Results & Conclusions: The results were as follows; 1. In change of BMD, 31cases(62%) increased and 19cases(38%) decreased. In 43`s infarction patients 26 cases(60%) increased and. in 7`s hemorrhage patients 5 cases(71%) increased. But significant increase was not. 2. In sexual change of BMD, BMD of female patients increased(p<0.05) significantly. 3. In ABR periodic change of BMD, BMD significantly decreased(p<0.01) according as ABR period were long. 4. In change of BMD according to smoking and drinking, BMD of non-smoking group increased(p<0.05) significantly. 5. In change of BMD according to hypertension, DM and osteoporosis, BMD of non-hypertension group increased(p<0.05) significantly. These results indicate that female, non-smoking group, non-hypertension and group that spent short ABR period BMD increased significantly.