중-노년층 여성의 실버타운 개발유형에 대한 태도분석

조성희,강혜경,Cho, Sung-Heui,Kang, Hye-Gyoung 한국주거학회 2008 한국주거학회 논문집 Vol.19 No.3

The purpose of this study was to investigate the attitude of the middle and old age about the elderly housing and the planning elements according to the types of silver town. For this study, a pre-interview and a survey method were used for data collection. A questionnaire survey of 372 women over 45 years old was carried out. Among the data, 321 cases were analyzed by SPSS for Windows V12.0. The major findings were as follows: 1) Regarding the elderly housing, While the couple cohabitation type preferred the existing housing and the general housing, the single habitation type preferred the apartment and silver town. Some people wanted silver town occupancy due to the decrease of children support burden, the other did not want it due to economical burden and the absence of homelike affection. When they move into silver town, they wanted to take money, clothes, and photo album. 2) In silver town development, while the couple cohabitation type preferred the apartment, independent house, the single type preferred the apartment, housing complex and group-home. The unit housing sizes of them were around 82.6 and 49.6 square meters respectively. In the space composition of unit housing, while the couple cohabitation type preferred bath room, kitchen, living room and two of bed room, the single type preferred one of bed room and bath room at least. On the other hand, this study found out that it was possible to plan the space for eating and washing as the common space. 3) According to single or couple, and ages, there were significant differences in preferred spatial planning elements, which needs to be reflected in the silver town development. These results can provide improvement guidelines for the development of the silver town with the differentiation of design factors for the silver town planners.

Anti-proliferative effect of Guichulpajing-Tang extract on MCF-7 cells

조성희,박경미,반혜란,Cho, Seong-Hee,Pak, Keung-Mi,Ban, Hye-Ran The Society of Korean Medicine Obstetrics and Gyne 2006 大韓韓方婦人科學會誌 Vol.19 No.1

이 연구는 MCF-7 인간 유방암 세포주에 대한 귀출파징탕(歸朮破?湯) 추출물의 증식억제효과 세포독성효과 세포사 유발효과를 확인하기 위하여 이루어졌다. MCF-7 인간 유방암 세포주는 Dulbecco's modified Eagle's medium/F12 (DMEM/F12)에 10% fetal bovine serum(FBS;Gibco) 와 항생제를 가하여 만든 배지를 이용하여 배양하였고, MCPF-7 세포를 96- well plate에 접종한 후 다양한 농도(0~2000g/ml)의 귀출파징탕(歸朮破?湯)이 든 배지로 처리하고 다양한 시간(48, 96, 192)동안 배양하여 현미경으로 관찰하고 각각 MTS assay kit를 이용하여 세포생존율을 측정하였다. 세포독성은 Sulforhodamine B assay 방법을 이용해 측정하였고 세포사 과정에서 MCF-7세포에서의 caspase 활성화를 측정하기 위해 Western blotting을 수행하여 poly ADP ribose polymerase(PARP)의 절단을 확인하였다. 실험결과 귀출파징탕(歸朮破?湯) 추출물에 의한 세포성장 및 독성효과는 시간 및 농도에 비례하는 것으로 나타났고 세포고사과정에서 작용하는 caspase의 전 기질인 PARP 절단량이 귀출파징탕(歸朮破?湯) 처리 농도와 시간에 비례하여 증가하였다. 이것은 caspase-3가 MCF-7 세포의 성장을 억제하는데 중요한 역할을 수행함을 의미한다. 따라서 귀출파징탕(歸朮破?湯)은 다양한 기전에 의해서 유방암 세포에 대한 억제효과를 가진다는 것을 인식할 수 있다.

1세 이하의 소아에서 발병한 신증후군의 임상적 고찰

조성희,이주훈,조영미,박영서,정해일,Cho, Sung-Hee,Lee, Joo-Hoon,Cho, Young-Mi,Park, Young-Seo,Cheong, Hae-Il 대한소아신장학회 2009 Childhood kidney diseases Vol.13 No.2

저자들은 1세 이하에 발병한 신증후군 환아 7명의 진단 및 치료를 경험하였기에 보고하는 바이다. 1996년부터 2007년까지 본원에서 1세 이전에 신증후군으로 진단 받은 환아 7명을 대상으로 병록 고찰을 통해 후향적으로 조사하였다. 선천성 신증후군은 3명, 영아형 신증후군은 4명 이었고, 남아가 1명, 여아가 6명으로 여아가 많았다. 6명에서 신생검을 시행하였고, 2명에서 미만성 메산지움 경화증, 2명에서 국소분절사구체경화증, 1명에서 Finnish형 신증후군 그리고 나머지 1명에서는 미세 변화형으로 확인되었다. 4명의 환아에서 NPHS2, PLCE1, 그리고 WT1의 유전자 분석을 시행하였고 2예에서 WT1 변이가 확인되었다. 선천성 신증후군으로 진단받은 3명 중 1명은 Finnish형 신증후군, 2명은 DDS로 진단받았고, 3명 모두 패혈증으로 사망하였다. 영아형 신증후군으로 진단받은 4명 중 2명은 사망하였고, 다른 1명은 관해가 되어 치료되었고, 나머지 1명은 치료 4개월 경 말기 신부전으로 진행하여 복막투석을 하고 있다. 1세 이전에 발병하는 선천성 신증후군은 소아 신증후군에 비하여 예후가 나쁘지만, 병력의 세밀한 검토, 임상소견 및 조직검사, 유전자 분석을 통한 정확한 진단이 빠르게 이루어져 조기 투석 및 신이식 등 적극적인 치료를 한다면 생존률의 향상을 기대할 수 있을 것이다. 대부분의 1세 이전 진단받는 신증후군은 유전적 신질환으로 추후 이들 환아들에 대한 유전형-표현형의 상관관계에 대한 추가 연구가 필요하다. Purpose : This study was performed to report the diagnosis and treatment of nephrotic syndrome manifesting in the first year of life. Methods : We retrospectively reviewed the clinical data with chart review in 7 patients who were diagnosed as nephrotic syndrome manifesting in the first year of life from 1996 to 2007. Results : Three patients had congenital nephrotic syndrome, the other 4 patients had infantile nephrotic syndrome. Their ages ranged from birth to 11 months and male to female ratio was 1 to 6. Renal biopsies were done in 6 patients. One patient had Finnish type congenital nephrotic syndrome, 2 patients had diffuse mesangial sclerosis, 2 patients had focal segmental glomerulosclerosis and 1 patient had minimal change disease. Genetic analyses of NPHS2, PLCE1, and WT1 were done in 4 patients and 2 of them had WT1 mutation. Among 3 patients with congenital nephrotic syndrome, 1 patient was diagnosed as congenital nephrotic syndrome of Finnish type and the other 2 patients were diagnosed as Denys-Drash syndrome. All of the patients with congenital nephrotic syndrome died due to sepsis. Among 4 patients with infantile nephrotic syndrome, 2 patients died and 1 had remission, another patient progressed to end stage renal disease. Conclusion : Most of nephrotic syndrome manifesting in the first year was hereditary renal disease. Patients with nephrotic syndrome manifesting in the 3 month of life had poorer prognosis and needed more aggressive management including early dialysis and renal transplantation might be considered compared with infantile nephrotic syndrome. Further genotype-phenotype correlation studies are needed.

레니텍^® 정(말레인산 에날라프릴, 10 mg)에 대한 에나레이스 정의 생물학적 동등성

조성희,하용화,홍성제,서성훈,류재환,김동현,이경태,Cho, Sung-Hee,Ha, Yong-Hwa,Hong, Sung-Je,Seo, Seong-Hoon,Rew, Jae-Hwan,Kim, Dong-Hyun,Lee, Kyung-Tae 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.3

The purpose of the present study was to evaluate the bioequivalence of two enalapril maleate tablets, $Renitec^{TM}$ (MSD Korea Ltd.) and $Enalace^{TM}$ (Welfide Korea Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty-four normal male volunteers, $22.33{\pm}2.55$ year in age and $66.54{\pm}8.30$ kg in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After two tablets containing 10 mg of enalapril maleate per tablet were orally administered, blood was taken at predetermined time intervals and concentrations of enalapril in plasma were determined using LC-MS-MS. Pharmacokinetic parameters such as $AUC_t,\;C_{max}\;and\;T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t,\;and\;C_{max}$ untransformed $T_{max}$. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals for the log transformed data were acceptance range of log0.8 to log1.25$(e.g.,\;log1.02{\sim}log1.14\;and\;log1.03{\sim}log1.19\;for\;AUC_t\;and\;C_{max},\;respectively)$. The major parameters, $AUC_t,\;and\;C_{max}$, met the criteria of KDFA for bioequivalence indicating that $Enalace^{TM}$ tablet is bioequivalent to $Renitec^{TM}$ tablet.

고층고밀 아파트단지의 노후도 평가지표 개발

조성희,이태경,Cho, Sung-Heui,Lee, Tae-Kyung 한국주거학회 2009 한국주거학회 논문집 Vol.20 No.4

High-rise and high-density apartment complexes have been built and supplied on a large scale in the 1st period of the New Town project in metropolitan areas since the late 1980s. Now It has become necessary to improve those apartment complexes, which have serious deterioration problems for aging more than about 20 years accompanying simultaneity and a large scale. The purpose of this research is to develop the evaluating indicators to measure the level of deterioration of apartments inclusively and practically in order to regenerate apartments as sustainable residential environments. This study is composed of the following four parts; (a) establishing the conceptual model of evaluation of apartment deterioration, (b) selecting evaluation items, (c) constituting evaluation measurement, and(d)weighting evaluation indicators. First, deterioration of apartments was conceptualized by physical. social, and economical aspects in terms of sustainable development and proposed the conceptual model of hierarchy structure of evaluation of apartment deterioration by literature reviews. Second, evaluating items were selected based on literature reviews of existing indicators and preceding studies about apartments of Korea and foreign countries. The evaluating indicators were identified as a total of 77 evaluating items which were composed of three dimensions and 9 attributes on the basis of the conceptual model. They cover comprehensive scope of the apartment such as unit, building, complex, and site. Third, as the measurement, the 5 point ordinal scale measure was suggested. The evaluating measurement including measure standards, measure methods, and measure contents were developed by each evaluating items. Lastly, the weighting of evaluating indicators was analyzed by AHP method conducted by survey on the expert group. Items were identified as high contributors or low contributors. The weighting of these items could suggest several evaluations according to the situation. The evaluation of the level of deterioration can be done by both total evaluation and a specific field of evaluation. In addition, it is easy to grasp deteriorated attributes or dimensions by providing a radar and bar chart showing evaluation results. These evaluating indicators could be a useful tool to grasp actual methods for the regeneration of apartments.

영역성 측면에서 공동주택 커뮤니티 계획요소에 관한 연구

조성희,최인영,Cho, Sung-Heui,Choi, In-Young 한국주거학회 2011 한국주거학회 논문집 Vol.22 No.1

The purpose of this study is to investigate design elements to strengthen apartment communities in territoriality perspectives. To this end, the study first identified the functions of territoriality to communities, and examined precedent studies on community planning. Then, looking into actual apartment, the study analyzed design elements of the apartments by territoriality functions, and found significant community-building and community-strengthening elements. The results of case studies are as follows: Specific design elements are 1) both individual and shared places from the perspective of possession, 2) both physical boundaries including visible mark and physical demarcation, and emotional boundaries including space arrangement and visual expansion from the perspective of boundary-regulation, 3) both physical proximity, such as providing space for physical encounter and easy access, and emotional proximity such as homogeneity and intimacy from the perspective of proximity 4) design differentiation and adoption of the design concept to express the identity of the community from the perspective of proximity personalization.

노인주거계획을 위한 노인가구의 고령기단계에 관한 연구

조성희,전은정,Cho, Sung-Heui,Jun, Eun-Jung 한국주거학회 2009 한국주거학회 논문집 Vol.20 No.5

The purpose of this study is to offer and analysis the stage of elderly in order to improve the quality of living environment of elderly in Korea. Taking into account the retirement age in Korea, those households with people over 60 years old were chosen for the investigation. For the study methods, an examination of documents centering on previous related studies and the analysis of references from the National Statistical Office, from which a general social situation can be clearly obtained, are used. The results are as follows; From viewpoint of the stage of elderly, Parents and children of families mostly live together stage 1 and 2, mostly live separately at stage 3, the rate of living together increases stage 4 and 5. In over stage 4, there are some cases in which the Korean tradition of three generations living under one roof appears as well. The residing period at one place becomes longer as people grow older, which shows clearly the characteristic of 'ageing in place', therefore in order to continue to provide housing support to the elderly, the characteristics of each elderly stage will have to be considered. In the life of the elderly, more and more hobby groups and meetings among the older population have been created, which means that elderly centered social activities will become more various, and facilities and community activated methods will have to be provided accordingly. Elderly people become less adaptable in new housing environments as they get older, therefore the housing has to accommodate their capability to adapt and the degree of aging. The stage of elderly can be used as a basic reference for a more effective solution when planning elderly housing in the future.

금속산화물을 첨가한 ZnGa2O4 : Mn 형광체막의 CL 특성 향상

조성희,유재수,이종덕 ( Sung Hee Cho,Jae Soo Yoo,Jong Duk Lee ) 한국화학공학회 1996 화학공학의이론과응용 Vol.2 No.2

족관절 유합술 후 발생한 거주상 관절염의 전경골 건 개재 관절성형술: 증례 보고

조성희,서민석,이은창,남대철,Cho, Seong-Hee,Seo, Min-Seok,Lee, Eun-Chang,Nam, Dae-Cheol 대한족부족관절학회 2021 대한족부족관절학회지 Vol.25 No.1

Ankle arthrodesis has been used frequently for end-stage ankle arthritis that does not respond to conservative treatment. On the other hand, there are concerns regarding the degenerative changes to the adjacent joint, such as the subtalar or talonavicular joint, due to the altered biomechanics after the loss of ankle motion. Because the arthrodesis for these midtarsal joints may overload stress on another contiguous joint, a salvage procedure should be considered rather than joint sacrificing. This paper reports a case of talonavicular arthritis after malunited ankle arthrodesis that was treated with interpositional arthroplasty using the tibialis anterior tendon.

고정된 효소의 Hysteresis 현상에 관한 연구

조성희,Cho, Sung-Hye 생화학분자생물학회 1983 한국생화학회지 Vol.16 No.2

고정된 단백질막중에서 확산되는 양성자의 이동에 기초를 둔 Eyring의 이론에 의하여 computer로 papain의 hysteresis 현상을 simulation하여 본 결과는 다음과 같았다. 즉 기질과 효소는 그들의 농도가 클수록 hysteresis를 잘 나타내었고 염과 완충용액은 이와반대로 그들의 농도가 적을수록 잘 나타내었다. 그리고 완충용액에 hysteresis 대한 현상은 염의 농도에 따라서 큰 영향을 받았으며, 이는 염을 첨가하였을때 보다 첨가하지 않은 상태에서 훨씬 더 잘 나타내었다. 이러한 현상이 실험적으로 동일한 결과가 나타날지는 실험적 연구가 뒷받침 되어야 할 것이다. Based on Erying's multibarrier activation process, a mathematical model was formulated to account for the proton diffusion through an enzyme attached at synthetic membrane. Then the phenomenon of enzyme hysteresis was tested by using computer-simulation with papain as an immobilized enzyme. The pH changes resulting from hysteresis appeared to occur markedly at higher concentration of the substrate (BSA) and enzyme, whereas at lower concentrations of salt and buffer, they appeared profoundly. Experimental support is needed to confirm the present results.