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5-Fluorouracil-지질 결합체 합성 및 in vitro 항암효과 평가
이희주(Hee Joo Lee),장판섭(Pan Sup Chang),김재완(Jae Wan Kim),정기화(Ki Hwa Jung),신순희(Soon Hee Shin),신혜순(Hae Soon Shin),정순복(Soon Bog Jung) 대한약학회 1990 약학회지 Vol.34 No.6
The FU-fat conjugates(4a-e) as a prodrug have been synthesized by condensing various fatty acids(1a-e) via isocyanates(2a-e) as carbamoyl group at N1-position of 5-fluorouracil and their structures characterized. Preliminary testing for their antitumor effect was carried out on leukemia L1210 cells in culture. Most of them(4a-d) like the parent FU exhibited less than 50% inhibition on grouth of the cultrued cells at the concentration of 1X10-7M. Only a dicarboxylic acid derivative, 4e, showed over 50% inhibition at the same level.
5-Fluorouracil-지질 결합체 및 in vitro 항암효과 평가
이희주,장판섭,김재완,정기화,신순희,신혜순,정순복 德成女子大學校 藥學硏究所 1991 藥學論文誌 Vol.2 No.1
The FU-fat conjugates(4a-e) as a prodrug have been synthesized by condensing various fatty acids(1a-e) via isocyanates(2a-e) as carbamoyl group at N^1-position of 5-fluorouracil and their structures characterized. Preliminary testing for their antitumor effect was carried out on leukemia L 1210 cells in culture. Most of them(4a-d) like the parent FU exhibited less than 50% inhibition on grouth of the cultrued cells at the concentration of 1×10^-7 M. Only a dicarboxylic acid derivative, 4e, showed over 50% inhibition at the same level.