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악성종양에서 골수면역신티그라피를 이용한 골수전이의 평가 : $^{99m}Tc$-MDP 뼈스캔과의 비교
이경한,최창운,방영주,정준기,정홍근,이명철,김병국,김노경,고창순,Lee, Kyung-Han,Choi, Chang-Woon,Bang, Yung-Jue,Chung, Jun-Key,Chung, Hong-Keun,Lee, Myoung-Chul,Kim, Byoung-Kook,Kim, Noe-Kyeong,Koh, Chang-Soon 대한핵의학회 1994 핵의학 분자영상 Vol.28 No.1
Although bone scan is a highly sensitive test for detecting bone metastasis, its findings are often limited in specificity and cannot be used for assessing the bone marrow. Bone marrow scintigraphy may provide useful information but previous experience with radiolabelled colloid has been disappointing. Recently, $^{99m}Tc$ labeled anti-granulocyte monoclonal antibody (anti-NCA-95 MAb) has been introduced as a new bone marrow imaging agent. To evaluate the usefulness of $^{99m}Tc$ anti-NCA MAb bone marrow scans for detecting skeletal metastasis, bone marrow scans of 44 malignant tumor patients were evaluated and compared with bone scan findings. Bone scan showed abnormal lesions in 26(59%) cases, and 18 of these patients also had an abnormal bone marrow scan. Seven of the 8 patients who had normal bone marrow scan despite bone scan lesions were confirmed to be free from metastasis. There was one case with a marrow defect despite normal bone scan but the presence of metastasis was not determined due to loss of follow up. Bone scan demonstrated a total of 64 lesions while bone marrow scan showed 38 lesions. Fifty percent (32/64) of the bone scan lesions had matching marrow defects while the remaining 50% did not. Most of these non matched lesions were suggested to be nonspecific lesions such as rib fractures or degenerative change. Meanwhile bone marrow scan was able to detect 6 new lesions not detected by bone scan, bit metastasis in each lesion was not confirmed. Bone marrow scan was also helpful in assessing equivocal bone scan lesions to be of metastatic nature in 10 patients by demonstrating a matched marrow defect. Thus $^{99m}Tc$ anti-NCA MAb bone marrow scan can help exclude metastasis in patients with nonspecific bone scan lesions and may be able to detect metastatic lesions not seen with bone scan. It appears useful as a complementary study to bone scan in evaluating malignant tumor patients.
이명철(Myung Chul Lee),이경한(Kyung Han Lee),윤병우(Byung Woo Yoon),이원용(Won Yong Lee),이기형(Ki Hyeong Lee),이상복(Sang Bok Lee),전범석(Beom S . Jeon) 대한핵의학회 1996 핵의학 분자영상 Vol.30 No.1
N/A Progressive supranuclear palsy (PSP) is a parkinson-plus syndrome characterized clinically by supranuclear ophthalmoplegia, pseudobulbar palsy, axial rigidity, bradykinesia, postural instability and dementia. Presence of dementia and lack of cortical histopathology suggest the derangement of cortical function by pathological changes in subcortical structures in PSP, which is supported by the pattern of behavioral changes and measurement of brain metabolism using positron emission tomography. This study was done to examine whether there are specific changes of regional cerebral perfusion in PSP and whether there is a correlation between severity of motor abnorma- ility and degree of changes in cerebral perfusion. We measured regional cerebral perfusion indices in 5 cortical and 2 subcortical areas in 6 patients with a clinical diagnosis of PSP and 6 healthy age and sex matched controls using Tc-99m-HMPAO SPECT. Compared with age and sex matched controls, only superior frontal regional perfusion index was significantly decreased in PSP (p〈0.05). There was no correlation between the severity of the motor abnormility and any of the regional cerebral perfusion indices (p〉0.05). We affirm the previous reports that perfusion in superior frontal cortex is decreased in PSP. Based on our results that there was no correlation between severity of motor abnormaility and cerebral perfusion in the superior frontal cortex, nonmotoric symptoms including dementia needs to be looked at whether there is a correlation with the perfusion abnormility in superior frontal cortex.
원발성 악성 골양종의 99mTc - MDP 골스캔 소견
고창순(Chang Soon Koh),이명철(Myung Chul Lee),정준기(June Key Chung),이동수(Dong Soo Lee),현인영(In Young Hyun),강흥식(Heung Sik Kang),이경한(Kung Han Lee),이상훈(Sang Hoon Lee),이한구(Han Koo Lee) 대한핵의학회 1995 핵의학 분자영상 Vol.29 No.1
N/A Tc-99m-MDP bone scan was performed in 31 patients with primary malignant bone tumors, 22 patients with osteogenic sarcoma, 5 patients with chondrosarcoma and 4 patients with Ewing's sarcoma. The findings were classified by isotope intensity of accumulation in tumor as grade 1 to 3, overall pattern of isotope distribution in tumor as grade 1 to 3, and distortion of bony outline as grade 1 to 3. Histologic classifications were correlated with scan findings in 22 patients with osteogenic sarcoma. The results were as follows. 1) In 22 patients with osteogenic sarcoma, markedly increased isotope intensity higher than sacroiliac joint with patchy areas of decreased intensity and severe bony distortion were found in 16 patients. The correlations between histologic classification and scan findings were not discovered. 2) In 5 patients with chondrosarcoma, mildly increased isotope intensity with patchy areas of increased intensity and mild bony distortion were found in 4 patients. 3) In 4 patients with Ewing's sarcoma, markedly increased homogenous intensity with moderate bony distortion were found in 3 patients. Conclusively there were common findings in each 3 primary malignant bone tumors and Tc-99m-MDP bone scan was complemented with radiologic studies in differentiating primary malignant bone tumors.
이경한(Kyong Han Lee),박주동(Ju Dong Park),문상영(Sang Young Moon) 한국국제상학회 2017 國際商學 Vol.32 No.3
본 연구에서는 한국과 총 5개 국가(칠레, 페루, 싱가포르, 인도, 미국)의 자유무역협정(FTA) 발효로 인한 양자간 교역증감효과를 국내 주요항(부산항, 인천항, 평택·당진항) 및 전국항 총 벌크물동량을 대상으로 실증분석하였다. 분석을 위해 대한민국과 FTA가 발효된 5개 국가(효과집단)와 2015년 기준 벌크물동량 항만교역량 기준 상위 80%에 해당하는 10개 국가(통제집단)의 시계열 및 횡단면으로 구성된 패널자료를 활용하였다. 분석결과 FTA 발효는 전국항 및 평택·당진항 벌크물동량 증대에 기여하였으며, 교역 증대효과는 항만별로 상이한 것으로 나타났다. FTA 이외의 GDP, 인구 변수의 경우 연구 대상 항만들의 벌크물동량 증대에 정(+)의 효과를 보였으며, 거리변수의 경우 부산항 벌크물동량과 부(-)의 효과를 보이는 것으로 분석되었다. 분석을 위한 기본 방법론으로 중력모형과 패널분석을 활용하였으며, 하우스만 테스트 결과 고정효과모형이 적합한 것으로 나타났다. Purpose : The objective of this study is to analyze the effects of bilateral FTAs on the bulk trade volume in Korea as well as at major ports in Korea including the ports of Pyeongtaek, Incheon, and Busan Research design, data, methodology : To achieve the above objective, this research use gravity model and panel analysis. With respect to this, data on 15 countries (the top 10 countries in terms of bulk trade volume and the 5 countries having a bilateral FTA with Korea) based on bulk trade volume, GDP, population, distance, and whether a bilateralF TA is concluded are collected for the period 1996 to 2015. Results : The conclusion of FTA has had a positive effect on the bulk trade volume in Korea because it eliminates trade barriers with partner countries. Conclusions : It was found that the influence of FTA conclusion differs from port to port.