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유효경 ( Hyo Kyeong Yu ),김태균 ( Tae Kyun Kim ),장이선 ( Yi Sun Jang ),김혜수 ( Hye Soo Kim ),이종민 ( Jong Min Lee ),김군순 ( Koon Soon Kim ) 전북대학교 의과학연구소 2011 全北醫大論文集 Vol.35 No.2
22세 여자 환자가 흉부 X-ray 상에서 우연히 발견된 종격동 확대로 내원하여 항갑상선글로불린항체 양성, 갑상선자극호르몬 결합억제 면역글로불린항체 음성인 그레이브스병에 동반된 흉선 증식증으로 진단을 받았고, 장기간의 항갑상선제 투여로 흉선증식증의 관해와 갑상선기능항진증의 정상화를 유도한 사례를 보고하는 바이다. Graves` disease is an autoimmune thyroid condition characterized by the production of auto-antibody against the TSH receptor of thyroid gland. The antibody mimics the effect of the thyroid stimulating hormone on thyroid cells, which stimulates autonomous production of thyroxine and triiodothyronine. It has been hypothesized that cross-reactivity of auto-antibody may result in thymic hyperplasia. However, TBII negative Graves` disease combined with thymic hyperplasia has not previously been reported. A 22-year-old woman incidentally detected anterior mediastinal mass was hospitalized for evaluation. She was diagnosed with TBII negative Graves` disease and thymic hyperplasia through CT guided biopsy. After anti-thyroid drug treatment, we restored both hyperthyroidism and thymic hyperplasia.
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증례 : 내분비-대사 ; 저생식샘자극호르몬생식샘기능저하증을 동반하는 근긴장디스트로피 1예
허준 ( Joon Hur ),유효경 ( Hyo Kyeong Yu ),장이선 ( Yi Sun Jang ),김혜수 ( Hye Soo Kim ),이종민 ( Jong Min Lee ),윤종수 ( Jong Su Yoon ),김군순 ( Koon Soon Kim ) 대한내과학회 2011 대한내과학회지 Vol.80 No.2S
56세 남자 환자가 당뇨병의 과거력 및 근력저하 그리고 생식샘기능저하증 소견을 보였다. 당뇨병의 신경병증을 검사하기 위해서 근전도검사를 시행하였고, 우연히 특징적인1형 근긴장디스트로피 소견을 발견하여 말초혈액에서 채혈한 혈액으로 유전자검사를 시행하였으며, 1형 근긴장디스트 로피로 진단하였다. 이 질환은 인슐린 저항성에 의한 당뇨병 및 일차 생식샘기능저하증을 보이는데, 환자의 외형에서 생식샘기능저하증의 모습이 있었고, 내분비호르몬검사상 저생 식샘자극호르몬생식샘기능저하증을 확인하였다. 현재 1형근육퇴행위축에 대한 뚜렷한 치료법은 없는 상태이고, 증상에 대한 보조적인 치료법으로 부족한 테스토스테론을 보충하는 것이 현재로서는 가장 현실적이고 적용 가능한 치료법이라 할 수 있다. 따라서 1형 근긴장디스트로피 환자에게 비교적 흔히 발생 하는 저생식샘기능저하증에 대해서 조기에 적절한 호르몬 대체요법을 고려해야 할 것으로 생각된다. Myotonic dystrophies (DM) are genetic neuromuscular diseases that have autosomal dominant inheritance and are characterized by progressive muscular weakness. Myotonic dystrophy type 1 (DM1) is caused by the expansion of an unstable CTG repeat in the DMPK (myotonic dystrophy protein kinase) gene on chromosome 19q13.3. Endocrine disorders associated with DM1 include primary hypogonadism with testicular atrophy and insulin resistance. However, DM1 accompanying hypogonodotropic hypogonadism has not previously been reported in Korea. A 56-year-old man who suffered from progressive weakness and walking disturbance for many years was hospitalized due to pneumonia. During his treatment for pneumonia, he received oral hypoglycemic agents because of hyperglycemia. He was diagnosed with DM1, based on the results of an EMG and genetic analyses. He also displayed anosmia and gynecomastia and was diagnosed with hypogonodotropic hypogonadism, based on the results of hormone tests. (Korean J Med 2011;80:S233-S238)
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김가영 ( Ka Young Kim ),차선아 ( Seon Ah Cha ),김영운 ( Young Woon Kim ),유효경 ( Hyo Kyeong Yu ),임예지 ( Ye Jee Lim ),류시영 ( Si Young You ),김성경 ( Sung Kyoung Kim ),김치홍 ( Chi Hong Kim ),김훈교 ( Hoon Kyo Kim ) 대한결핵 및 호흡기학회 2012 Tuberculosis and Respiratory Diseases Vol.72 No.2
Cough syncope is characterized by the loss of consciousness occurring after vigorous coughings. There are approximately 90 reported cases of cough syncope within the medical literature. Most cases involving middle aged, overweight and chronic bronchitic male smokers. Although many studies have been published in the medical literature, the mechanism and pathophysiology for cough syncope has not been well established. Cough syncope is treated by correcting the underlying cause when identified, or by avoiding conditions that may cause the cough syncope. In addition, cough suppression modalities can also be used. We herein report 3 cases of cough syncope presenting in lung cancer patients.
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