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우준하 ( Jun Ha Woo ) 중앙대학교 학교체육연구소 2014 Asian Journal of Physical Education of Sport Scien Vol.4 No.-
The purpose of this study is to provide with higher quality of learner centered P.E textbook, giving supplementary and feasible information to textbook developers throughout analyzing learners`` perception on the external system of elementary Physical Education textbooks. In order to achieve the purpose, a questionnaire has been distributed and implemented for the number of 975 fifth and sixth graders in 7 different schools, located in 5 different areas of Seoul, from which the frequency analysis through IBM SPSS Statics Program ver.22 have also been used to make the following conclusions. First, in regard to the representation of P.E textbook, elementary school students have made positive assessment for its adequate fonts, readability and effective expression. Second, in regard to the editing design of P.E textbook, elementary school students have made a positive assessment for its interesting cover-configuration and easily readable font and illustration. Lastly, in regard to the material of P.E textbook, elementary school students have made positive conclusion for the condition of, its paper, print status, shape, size and amount of pages. Upon these conclusions above, some suggestions are indicated as follow. First, it would be required to extend the number of students, and the areas to the nationwide for further research. Second, in order to understand and provide high-quality of P.E textbook, the number of research on the learners’ perspective need to be increased in the future.
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이경열 ( Kyung Ywal Lee ),우준하 ( Jun Ha Woo ),박천욱 ( Chun Wook Park ),이철헌 ( Cheol Heon Lee ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.4
The pat,hogenesis of atopic dermititis(AD) is still undefined. The prominent immunologic abnormalities associated with AD are defective cell-mediated immunity and increased IgE production. Also, the predominant CD4 subset in the skin lesion of AD is a Th2-like. Thymopentin, the active pentapepide of a thymic hormone, promotes differentiation of thymocytes and exhibits immunomodulating function. We experienced 2 case. of severe AD patients who were treated with subcutaneous injection of thymopentin three times a week for 6 weeks or 8 weeks. We compared the effects of cyclosporine A(CsA), FK -506 and thymopentin on the production of IL-2, IL-3, IL-4 and sIL-2R in vitro. In patient 1, there was no clinical response with thymopentin therapy. There was no difference in the serum IgE levels between before and after treatment. The ratio of Th/Ts was increased after treatment. In vitro study, CsA and FK-506 inhibited the production of IL-2, IL-3, IL 4 and sIL-2R, and thymopentin inhibited the production of IL-2, IL-3, IL-4 and sIL-2R. In patient 2, the clinical score of the patient was improved from 15 to 10 after treatment with thymopentin. There was no difference in the serum IgE level. The ratio of Th/Ts was decreased after treatment. In vitro study, the production of IL-2, IL-3 and IL-4 were decreased in lymphocytes added with CsA and FK-506, but the production of sIL-2R was increased by CsA and FK-506. Also, the production of IL-3 and IL-4 were increased in lymphocytes added with thyrnopentin, but the proluction of IL-2 and sIL-2R were increased by thymopentin. Our data suggest that thymopentin could be effective in the treatment of severe AD through the upregulation of Thl-like subset, not via the downregulation of Th2-like subset. (Kor J Dermatol 1996;34(4): 668-672)
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이철헌,박천욱,우준하,신경열 대한피부과학회 1998 大韓皮膚科學會誌 Vol.36 No.6
Cephalosporins are B-lactam antibiotics. They are usually bactericidal in action and act by inhibiting mucopeptide synthesis in the bacterial cell wall. Cephalosporins have been used widely in Korea. However, allergic contact dermatitis to cephalosporins has not been reported in the Korean dermatologiy literature. We report a case of allergic contact dermatitis due to cephalosporins in a 23-year-old nurse who suffered from itchy, erythematous patches and plaques with numerous fissures on both hands. A patch test with ceftriaxone and a prick test with cefotiam were positive.
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Cytokeratin Expression in Seborrheic Keratosis
김종민,이철헌,박천욱,우준하 대한피부과학회 1997 Annals of Dermatology Vol.9 No.2
Background : Using biochemical and immunohistochemical studies, alterations of cytokeratin expression has been reported in seborrheic keratosis. Objective : To further investigate the cytokeratin expression in seborrheic keratosis, we have done immunohistochemical staining using a panel of specific anti-keratin antibodies in this study. We also observed the cytokeratin expression in the hair, sebaceous gland and sweat gland of the some epidermis. Methods : Twenty cases of seborrheic keratosis were collected from the pathologic files. The histological types included acanthotic type (13 cases), hyperkeratotic type (5 cases), and pigmented type (2 cases). All tissues had been fixed in formalin and then paraffin-embedded according to conventional procedures. Each section was mounted on a gelatin-coated glass slide, and incubated with various anti-keratin antibodies. The sections were then immunostained using the avidin-biotin-peroxidase complex system. The peroxidase reaction was visualized with diaminobenzidine (DAB). Results : 1. Cytokeratin expression in seborrheic keratosis lesions On staining with 34βB4 (K1), several staining patterns in the suprabasal layers of the epidermis were observed in 10 out of 20 cases. Using the AE1 (K10, 14, 15), we observed focal staining in 2 cases. We observed several positive staining patterns in 5 cases with K13, 16 antibody. On staining with K10 antibody, we observed focal or irregular staining patterns in 14 cases. Focal staining was also observed with K5, 8 antibody in one case. 2. Cytokeratin expression in the hair, sebaceous gland and sweat gland On immunoperoxidase staining of hair, there were positive reactions with CAM5.2 (K8, 18) in 2 cases. There were positive reaction with K13, 16 antibody in one case, with 34βB4 (K1), and K10 antibody in 3 cases, and with K17 antibody in 2 cases. On immunoperoxidase staining of sebaceous glands, there was one positive reaction with CAM5.2 (K8, 18) in the suprabasal cells of sebaceous glands and with K13, 16 antibody in sebaceous ducts. There were positive reactions with K17 antibody in the sebaceous ducts in 2 cases, and with K 1 antibody in the sebaceous glands in one case. Using 34βB4 (K1), 4 out of 20 cases showed positive reactions in sweat glands. On staining with AE1 (K10, 14, 15), positive reactions were observed in 8 cases. Staining with CAM5.2 (K8, 18) showed positive reactions in 14 cases. There were positive reactions with K19 antibody in 9 cases. Conclusion : Our data suggests that the predominant keratin expression in the tumor cells of seborrheic keratosis is high molecular weight keratin (K1/K10) rather than other lower molecular weight keratin. Tumor cells show some proliferative activity and monoclonal antibody K19 could be a marker for eccrine sweat glands like CAM5.2 (K8, 18).
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