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Cylosporin A가 아토피 피부염의 면역계에 미치는 영향
박천욱(Chun Wook Park),강윤서(Yun Seo Kang),이철헌(Cheol Heon Lee) 대한피부과학회 1993 대한피부과학회지 Vol.31 No.2
Background : Atopic dermatitis(AD) exibit multiple immune akno malities including elevated serum IgE levels and impaired cell mediated immunity, but basic immunology defect is largely unknown. Obtive : The purpose of this study was to evaluate the immnologic changes after treatment with Cyclosporin A(CsA) in AD patients. Methods : Eight patients of severe AD were treated with CsA(4mg/kg body weight per day) for 5 weeks, and evaluated clinical and immunological parameters before aid after treatment. Reeults : Peripheral blood eosinophil counts were significantly decreased after treatment(P<0.05), and serum IgE level was decressed but not significantly. In immediate hypersensitivity reaction by pinprick test, antigen score was.significantly decreased, and in the evaiuation of cell mediated immunity to recall antigens, total induration score was significantly increased(p<0.05). The number of helper T cell and helper/suppressor 7 cell ratio in peripheral blood, and the niimber of helper T and suppressor T cell in skin lesion were both significantly decreased after treatment(P<0.05). Clinical state after treatrnent was good in all of patients. Conclusion : The results indicate that CsA act on peripheral blood osinophil and immediate and delayed hypersensitivity reaction as well as helper T-cells in peripheral blood and skin lesion, and it may by useful in the treatrnent of severe AD. (Kor J Dermatol 1993; 31(2): 210-216)
박천욱(Chun Wook Park),이종육(Jong Yuk Yi),김형옥(Hyung Ok Kim),김정원(Chung Won Kim) 대한피부과학회 1986 大韓皮膚科學會誌 Vol.24 No.2
The aim of the present work is to evaluate the most accurate technique for analysirig low levels of serum IgE. Following results are obtained from experiments by PRIST, Overnight PRIST, PRIST using RAST anti-IgE tracer and Overnight PRIST using RAST anti-IgE tracer methods with cord serum and maternal serum of 21 individuals respectively. 1) There was no statistical significance in maternal serum IgE titer using above 4 methods. However, the higher level of IgE titer was found in PRIST method when IgE was over 190 IU/ml(5 cases) estimated by PRIST method and in Overnight PRIST using RAST anti-IgE tracer method when Ig.E was below lgp IU/ml (16 cases) (p40.05). 2) In cord serum IgE titer, only Overnight PRIST using RAST anti-IgE tracer method showed statistical significance. 3) The most desirable correlation coefficient between maternal serum and cord serum IgE titer was estimated by Overnight PRIST using RAST anti-IgE tracer method than any other rnethods.
박천욱(Chun Wook Park),최성우(Sung Woo Choi),주은희(Eun Hee Choo),고익준(Ik Jun Ko),김형옥(Hyung Ok Kim),김정원(Chung Won Kim) 대한피부과학회 1984 대한피부과학회지 Vol.22 No.6
The relation of atopic dermatitis to various manifestations of ocular disease has been documented in the dermatologic literature. Several lines of evidence suggest that patients with atopic dermatitis have defective ceil-mediated immunity and decreased cellular hypersensitivity. In this paper, we presented two cases of atopic dermatitis developing ocular complication and abnormal immune response in vivo and in vitro during the course of atopic dermatitis.
박천욱(Chun Wook Park),허동(Dong Houh),조백기(Baik Kee Cho),방승규(Seung Kyu Bang) 대한피부과학회 1985 대한피부과학회지 Vol.23 No.2
We report 3 cases of traumatic nail dystrophy,, developed in 11 years old girl (Case 1), 10 years old(case 2) and 15 years old boys(case 3) Dystrophic nails show transverse ridging with longitudinal axis on the both thumb nails in case 1 R 3, and transverse ridging with transverse axis on the left thumb nail in case 2 Mothers overprotection(case 1, 3) and indifference(case 2) were considered to be of the most important causes of the nail biting and playing with nails in our cases.
박천욱 ( Chun Wook Park ),이종육 ( Jong Yuk Yi ),김시용 ( Si Yong Kim ),조백기 ( Baik Kee Cho ),허원 ( Won Houh ) 대한피부과학회 1986 대한피부과학회지 Vol.24 No.3
We report herein a case of subcutaneous fat necrosis in an 1-month-old abandoned female neonate who had subcutaneous nodule on the right cheek and linear cord-like subcutaneous nodule on the right upper arm which has been evident from the second post-delivery day. Hiatopathologic findings revealed massive subcutaneous fat necroais with infiltration of foreign body giant cells and inflammatory cells. Calcigm was also deposited but no needle shaped cleft was formed in the fat cells. The akin lesion resolved spontaneously after 2 months.
박천욱(Chun Wook Park),김시용(Si Yong Kim),허원(Won Houh) 대한피부과학회 1985 대한피부과학회지 Vol.23 No.2
Desmoplastic trichoepithelioma, a tumor of hair follicle, is usually seen as solitary lesions. Its clinical configuration is hard and annular, asympromatic, white or yellowish and varied in size from 3 to 8 mm, but the appearance of these lesion is not so distinctive to hair follicle tumors that the diagnosis is estabilished by the histopathologic findings. Microscopical findings of desmoplastic trichoepithelioma consist of narrow strands of tumor cells, horn cyst, desmoplastic stroma. We present here a case of desmoplastic trichoepitheliorna, which develops as 6 mm sised papule on the left cheek in a 57-year-old. woman.
수종 피부질환에서 회상 항원들에 의한 피부지연 면역반응
박천욱(Chun Wook Park),최성우(Sung Woo Choi),김형옥(Hyung Ok Kim),김정원(Chung Won Kim) 대한피부과학회 1985 대한피부과학회지 Vol.23 No.4
Authors have performed patch test to evaluate the differences between the allergic contact dermatitis to topical medicaments and to the other substances including cosmetics. One hundred eighteen patients were evaluated according to age, sex, and causative agents of the disease. Furthermore, these patients were analysed as to the causative allergic contact factors by clinical inspection and history. The most common causative allergic contact factors by clinical, history and patch test were topical medicarnents(45.8%), cosmetics(24. 6%), rubbery(10.2%), and metals(8.59%.). The common etiogloic medicaments of contact dermatitis were Madecassol, Betadin, Tiger balm, Canesten, Mercurochrom, and Tego solution. The causative agents were confirmed by the patch test with Hollister-Stiers standard allergens in 57 patients from Jan. 1983 to Dec. 1984, 1 hirty eight among 57 patients were positive to patch test, Back ground possible explanation of the patch test results were discussed and a comparison was made between this report and others.
Pruritic Urticarial Papules and Plaques of Pregnancy ( PUPPP )
박천욱(Chun Wook Park),김영환(Young Whan Kim),조백기(Baik Kee Cho),허원(Won Houh) 대한피부과학회 1986 대한피부과학회지 Vol.24 No.3
We report herein a case of PUPPP in a 26-year-old-primigravida with urticarial papules and plaques on the abdomen and thigh which developed at 39th week of the pregnancy. Histopathologic findings revealed focal spongiosis in the epidermis and lymphocytic perivascular infiltration in the dermis. The skin lesion resolved spontaneously after delivery and the new-born had no specific abnormalities.
Chamber 크기와 검사 시약의 양이 피부 자극반응에 미치는 영향
이경열,박천욱,이철헌 ( Kyung Ywal Lee,Chun Wook Park,Cheol Heon Lee ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.3
Background: There are some variables including chamber size in irritant patch test responses. Several non-invasive bidengineering methods for quantifying and obtaining information have been developed in recent decades. Objective : Our study was done to compare the effect of chamber size and the volume effect on the irritation potential of 1% SLS solution. Methods : Patches with 1% sodium lauryl sulfate(SLS) solution were applied to the volar forearm of 14 healthy volunteers for 24 h. Finn chambers with 8mm(20ul), 12mm(60pl), 18mm(80ul, 200ul) inner diameters were used. Visual score and transepidermal water loss (TEWL) were measured at 30 min after removal of the patches, and every 24 h up to 4 days. Results : The results are summarized as follows. 1. Visual scores were 0.18+0.32(8mm), 0.75+0.33(12mm) and 0.64+0.41(18mm) at 24 h after removal of 1% SLS and were 0.11+0.29, 0.50+0.34 and 0.25+0.26 on 4 days after removal. They were inereased 30 min and 24 h after removal and decreased towards normal 4 days after removal. By chamber size, the skin response with the large Finn chamber(12mm) increased more significantly than with the small Finn chamber(8mm). However, there were no significant differences in skin response between large and extralarge Finn chambers(18mm). 2. TEWL values were 11.86+4.09, 23.05+6.1l and 22.24+7.54g/m/h at 30 min after removal and were 9.37+2.30, 1..49+3.08 and 14.56+5.00g/m/h on 4 days after removal. They were increased 30 min after removal and decreased towards normal 4 days after removal. By chamber size, their results were the same as visual scores. 3. By visual score and TEWL, the skin response with 200pl of 1% SLS increased more significantly than 80pl in the extralarge Finn chamber. Conclusion : The small Finn chamber may be too small to elicit sufficient cutaneous irritation for evaluation. The large Finn chamber having larger test areas may be suitable to yield positive reactions to certain irritants. Also, the quantity of test solution per mm skin may be of importance for the skin response. (KOr J Dermatol 1997;35(3): 424-430)