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인지질/세라마이드 혼합물의 상호적 자가회합 특성을 활용한 수화 액정형 베시클 제조
박민선 ( Min Seon Park ),최정원 ( Jeong Won Choi ),이설훈 ( Seol-hoon Lee ),진병석 ( Byung Suk Jin ) 한국공업화학회 2020 공업화학 Vol.31 No.5
인지질과 세라마이드 간 상호적 자가회합 특성을 활용하여 수화 액정형 베시클 제조를 시도하였다. 인지질과 세라마이드의 혼합지질에 에지 액티베이터를 첨가하면 난용성의 세라마이드를 고 함량으로 함유하는 베시클 제조가 가능하였다. 본 연구에서는 인지질, 세라마이드, 에지 액티베이터의 혼합 조성에 따른 수화 액정상의 구조적, 열적 특성 등의 변화를 관측하고, 혼합 조성을 달리하여 만든 베시클의 입자크기 및 베시클 분산액의 안정성을 비교하였다. 실험 결과, 인지질과 세라마이드 간 혼합에서 세라마이드 비율을 최대 70%까지 늘려서, 베시클 분산액 전체 대비 세라마이드를 3.5 wt% 함유되는 제형을 제조할 수 있었다. An attempt was made to prepare hydrated liquid crystalline vesicles by utilizing a mutual self-assembly between phospholipid and ceramide. When an edge activator was added to the mixture of phospholipid and ceramide, it was possible to prepare a vesicle containing a high content of poorly soluble ceramide. In this study, we investigated changes in structural and thermal behaviors of the hydrated liquid crystalline phase according to the mixed composition between phospholipid, ceramide, and sodium deoxycholate. Also, both the droplet size of the vesicles with different composition and stability of the vesicle dispersion solution were observed. From results of the experiments, by increasing the ratio of ceramide up to 70% in the mixture between phospholipid and ceramide, a formulation containing 3.5 wt% of ceramide in the vesicle dispersion solution could be obtained.
부갑상샘절제술 이후 뼈스캔에서 발적 현상을 나타낸 갈색종
신광호 ( Kwang Ho Shin ),박설훈 ( Seol Hoon Park ),백소라 ( So Ra Baek ),채선영 ( Sun Young Chae ),고정민 ( Jung Min Koh ),김재승 ( Jae Seung Kim ),문대혁 ( Dae Hyuk Moon ),류진숙 ( Jin Sook Ryu ) 대한핵의학회 2009 핵의학 분자영상 Vol.43 No.5
Brown tumor is the benign bone lesion consists of woven bone and fibrous tissue without matrix, which develop due to chronic excessive osteoclastic activity such as hyperparathyroidism. Usually they appear with normal uptake or occasionally focally increased uptake on bone scan. We present a case with brown tumor shown more increased uptake and more number of lesions on bone scan after parathyroidectomy, and lesser increased uptake on serial bone scans without any other treatment through several months. This finding is thought to be similar to `flare phenomenon` which is occasionally seen after treatment of metastatic bone lesions of malignant cancer, and may represent curative process of brown tumor with rapid normal bone formation. (Nucl Med Mol Imaging 2009;43(5):495-498)