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알츠하이머병에서 혈장 크레아틴과 염증반응, 인지기능과의 연관성
김민애(Minae Kim),오대종(Dae Jong Oh),김현정(Hyunjeong Kim),조소연(So Yeon Cho),하정희(Junghee Ha),이준영(Jun-Young Lee),김어수(Eosu Kim),김근유(Keun You Kim) 대한노인정신의학회 2021 노인정신의학 Vol.25 No.2
Objective: Creatine, energy buffer in high energy demanding systems including muscle and brain, may play a beneficial role against neuroinflammation in Alzheimer’s disease (AD), and thus be a potential biomarker. This study aimed to compare the levels of plasma creatine between persons with and without AD and investigate associations of plasma creatine levels with cognitive function and blood-based inflammatory markers. Methods: We classified elderly participants by cognitive statuses: normal cognition (NC, n=17), mild cognitive impairment (MCI, n=21), and AD (n=21). To assess cognitive function and inflammatory condition, we performed neuropsychological tests and measured plasma C-reactive protein (CRP) levels, respectively. Results: Plasma creatine levels were comparable among participants with AD, MCI, and NC. In overall participants, plasma creatine levels were not associated with neuropsychological test scores, but negatively associated with plasma CRP levels. In AD group, plasma creatine levels were negatively associated with neuropsychological test scores and, although not significant, CRP levels (p=0.086). In participants without AD (NC plus MCI), these associations disappeared. Conclusion: Plasma creatine levels may not be useful as a biomarker indicating cognitive statuses. However, our results suggest that, in AD, plasma levels of creatine might reflect the extent of neuroinflammation as well as cognitive deterioration.
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이영민(Young Min Lee),김어수(Eosu Kim),박제민(Je Min Park) 대한노인정신의학회 2012 노인정신의학 Vol.16 No.2
Vascular dementia (VaD) is a dementia syndrome produced by vascular damage to the brain and increases in incidence with ad-vancing age. Early Identification and diagnosis of VaD is particularly importent since its course may be modifiable through control-ling vascular risk factors. VaD is heterogeneous and consists of several syndromes : multi-infarct dementia, strategic single infarcts dementia, and subcortical vascular dementia. The diagnosis of VaD is based on several features 1) dementia, 2) evidence of cere-brovascular disease, and 3) temporal relationship between dementia and cerebrovascular disease. Treatment of VaD includes control of vascular risk factors, prevention of further vascular injury and treatment of cognitive impairment. Cholinesterase inhibitors pro-vide symptomatic benefits in treatment of VaD.
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뇌척수액과 말초혈액 내 알츠하이머병의 생화학적 생체표지자
이영민(Young Min Lee),최원정(Won-Jung Choi),박민선(Minsun Park),김어수(Eosu Kim) 대한노인정신의학회 2012 노인정신의학 Vol.16 No.1
The diagnosis of Alzheimer’s disease (AD) is still obscure even to specialists. To improve the diagnostic accuracy, to find at-risk people as early as possible, to predict the efficacy or adverse reactions of pharmacotherapy on an individual basis, to attain more reliable results of clinical trials by recruiting better defined participants, to prove the disease-modifying ability of new candidate drugs, to establish prognosis-based therapeutic plans, and to do more, is now increasing the need for biomarkers for AD. Among AD-related biochemical markers, cerebrospinal beta-amyloid and tau have been paid the most attention since they are materials directly interfacing the brain interstitium and can be obtained through the lumbar puncture. Level of beta-amyloid is reduced whereas tau is increased in cerebrospinal fluid of AD patients relative to cognitively normal elderly people. Remarkably, such information has been found to help predict AD conversion of mild cognitive impairment. Despite inconsistent findings from previous studies, plasma beta-amyloid is thought to be increased before the disease onset, but show decreasing change as the disease progress. Regarding other peripheral biochemical markers, omics tools are being widely used not only to find useful biomarkers but also to generate novel hypotheses for AD pathogenesis and to lead new personalized future medicine.
KCI
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