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전신홍반루푸스에 의한 속발성 항인지질증후군에 동반된 정맥성 족부궤양 치험
김범경 ( Beom Kyung Kim ),최상태 ( Sang Tae Choi ),손명균 ( Myoung Kyun Son ),이광훈 ( Kwang Hoon Lee ),이상원 ( Sang Won Lee ),정세진 ( Sae Jin Chung ),길지훈 ( Ji Hoon Gil ),박용범 ( Yong Beom Park ),이수곤 ( Soo Kon Lee ) 대한류마티스학회 2007 대한류마티스학회지 Vol.14 No.1
Antiphospholipid syndrome is an autoimmune disorder characterized by recurrent arterial or venous thrombosis, and pregnancy loss. A 57-year-old woman was admitted for aggravation of both leg ulcers. Venogram showed chronic venous obstructions at both lower extremities, and chest x-ray and computed tomography revealed serositis in pericardium and pleura. The laboratory tests revealed pancytopenia, and positive tests for antinuclear antibody, anti-dsDNA antibody, lupus anticoagulant and anticardiolipin antibody, which led to a diagnosis of antiphospholipid syndrome secondary to systemic lupus erythematous. After medical treatments by anticoagulation and immunosuppression, and surgical managements including subtotal skin graft and local flap surgery, leg ulcers had been successfully treated without recurrence. Recognition of antiphospholipid syndrome as a cause of venous ulcer and the treatment plans including anticoagulation and surgical management is important in proper managements.