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Redox regulation of the tumor suppressor PTEN by glutathione
Kim, Yujeong,Song, Yong Bhum,Kim, Tae-Youl,Kim, Inyoung,Han, Seong-Jeong,Ahn, Younghee,Cho, Seung-Hyun,Choi, Cheol Yong,Chay, Kee-Oh,Yang, Sung Yeul,Ahn, Bong Whan,Huh, Won-Ki,Lee, Seung-Rock Elsevier 2010 FEBS letters Vol.584 No.16
<P><B>Abstract</B></P><P>Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) expressed in <I>Saccharomyces cerevisiae</I> was reversibly oxidized by hydrogen peroxide and reduced by cellular reductants. Reduction of hPTEN was delayed in each of <I>S. cerevisiae</I> gsh1Δ and gsh2Δ mutants. Expression of γ-glutamylcysteine synthetase Gsh1 in the gsh1Δ mutant rescued regeneration rate of hPTEN. Oxidized hPTEN was reduced by glutathione in a concentration- and time-dependent manner. Glutathionylated PTEN was detected. Incubation of 293T cells with BSO and knockdown expression of GCLc in HeLa cells by siRNA resulted in the delay of reduction of oxidized PTEN. Also, in HeLa cells transfected with GCLc siRNA, stimulation with epidermal growth factor resulted in the increase of oxidized PTEN and phosphorylation of Akt. These results suggest that the reduction of oxidized hPTEN is mediated by glutathione.</P>
대·소조기시 한강하구 석모수로에서 단면 잔차류와 성층간의 관계 연구
최낙용(Choi, Nak-Yong),윤병일(Yoon, Byung-Il),김종욱(Kim, Jong-Wook),송진일(Song, Jin-Il),임은표(Lim, Eun-Pyo),우승범(Woo, Seung-Bhum) 한국해안해양공학회 2012 한국해안해양공학회 논문집 Vol.24 No.3
본 연구는 강화도 서측에 위치한 조력 발전 유력 후보지인 석모수로의 북단과 남단의 2개 정선에서 13시간 연속으로 단면 유속과 염분 관측을 대,소조기시 각각 수행하여 단면 내 잔차류의 변화와 성층간의 관계를 분석 하였다. 석모수로의 염분 분포는 대,소조기에 따라 서로 다른 염분 구조 형태를 보이며, 염분의 침입 범위 또한 다르게 나타난다. 잔차류 성분은 13시간 유속 성분에서 최소 자승법을 이용하여 추출한 M₂분조와 M₄분조를 제거하여 구하였고, 석모수로 북단과 남단에서 표층의 잔차류 성분은 모두 남쪽 방향의 잔차류 성분을 보인다. 그러나 두 정선의 단면 저층에서는 표층과 저층간의 2층 흐름 구조를 만드는 북쪽 방향의 잔차류가 관측되는데 그 위치는 대,소조기에 따라 다르게 나타나 시,공간적으로 다른 결과를 보인다. 북쪽 방향의 잔차류와 성층의 관계를 분석하기 위해서 Richardson number와 Simpson-hunter index를 분석하였다. 이러한 결과를 종합할 때, 석모수로의 단면 잔차류 패턴은 Richardson number가 상대적으로 급격하게 커지고 Simpson-hunter index가 4 이상 나타나는 지역, 즉 성층이 강하게 나타나는 지역에서 2층 흐름 구조를 보인다. This study analyzed cross-sectional variations in residual current and strengths of stratification by observing cross-sectional velocity and salinity during spring tide and neap tide, respectively, for continuous 13-hour periods at 2 observation lines at northern and southern end of Seokmo Channel, which is located west of Ganghwado. Salinity distribution of channel depends on not only neap and spring tide but also impact of salinity. The residual current component was obtained by removing M₂ and M₄ tidal components that were extracted using the least squares method on 13-hour velocity component. Cross-section of residual velocity at northern and southern end of Seokmo Channel exhibited southward residual components at channel's surface layer, but northward residual current was observed at channel's bottom layer, clearly showing a 2-layer tidal circulation between surface and bottom layers. The variation in location of appearing northward residual current according to changes in spring and neap tidal cycle and its correlation with stratification were analyzed using the Richardson number and Simpsonhunter index. At northern and southern end of Seokmo Channel, northward residual current appears in the location where Richardson number is large, Simpson-hunter index appears as a value greater than 4.