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The Mothers and Children’s Environmental Health (MOCEH) study
Kim, Byung-Mi,Ha, Mina,Park, Hye-Sook,Lee, Bo Eun,Kim, Young Ju,Hong, Yun-Chul,Kim, Yangho,Chang, Namsoo,Roh, Young-Man,Kim, Boong-Nnyun,Oh, Se-young,Ha, Eun-Hee Springer Netherlands 2009 European journal of epidemiology Vol.24 No.9
<P>The MOCEH study is a prospective hospital- and community-based cohort study designed to collect information related to environmental exposures (chemical, biological, nutritional, physical, and psychosocial) during pregnancy and childhood and to examine how exposure to environmental pollutants affects growth, development, and disease. The MOCEH network includes one coordinating center, four local centers responsible for recruiting pregnant women, and four evaluation centers (a nutrition center, bio-repository center, neurocognitive development center, and environment assessment center). At the local centers, trained nurses interview the participants to gather information regarding their demographic and socioeconomic characteristics, complications related to the current gestation period, health behaviors and environmental factors. These centers also collect samples of blood, placenta, urine, and breast milk. Environmental hygienists measure each participant’s level of exposure to indoor and outdoor pollutants during the pre- and postnatal periods. The participants are followed up through delivery and until the child is 5 years of age. The MOCEH study plans to recruit 1,500 pregnant women between 2006 and 2010 and to perform follow-up studies on their children. We expect this study to provide evidence to support the hypothesis that the gestational environment has an effect on the development of diseases during adulthood. We also expect the study results to enable evaluation of latency and age-specific susceptibility to exposure to hazardous environmental pollutants, evaluation of growth retardation focused on environmental and genetic risk factors, selection of target environmental diseases in children, development of an environmental health index, and establishment of a national policy for improving the health of pregnant women and their children.</P>
Dopamine Transporter SPECT of a Liver Cirrhotic with Atypical Parkinsonism
KIM, Jongchul,KIM, Jong-Min,KIM, Yu Kyeong,SHIN, Jung Woo,CHOI, Seong Hoon,KIM, Sang Eun,KIM, Yangho National Institute of Industrial Health 2007 Industrial health Vol.45 No.3
<P>High level of exposure to manganese (Mn) can cause a clinically and pathophysiologically distinct syndrome from idiopathic Parkinson's disease (PD). We describe the clinical features and results of [<SUP>123</SUP>I]-fluoropropyl (FP)-CIT SPECT of a liver cirrhotic with atypical parkinsonism. The patient developed atypical parkinsonian features associated with elevated blood Mn from hepatic dysfunction. [<SUP>123</SUP>I]-FP-CIT brain SPECT images of dopamine transporter (DAT) demonstrated overall normal range of DAT uptake in the striatum although there were scattered small hypodense regions. The globus pallidum had increased signal on T1-weighted magnetic resonance imaging (MRI). All these findings are compatible with those of manganism, and are remarkably different from that in PD.</P>
쿡탑 더블 버너에서 내부 화염 안정화를 통한 열효율 향상에 관한 실험적 연구
김양호(Yangho Kim),김승윤(Seungyoon Kim),이종호(Jongho Lee),김영수(Youngsoo Kim),전충환(Chunghwan Jeon) 한국연소학회 2019 한국연소학회지 Vol.24 No.2
An experimental study was performed to investigate the stabilization mechanism of inner flame in a double-flame cooktop burner. Several hypotheses were made on CO emission and unstable mechanisms, such as concentration and flow effects. Flow characteristics and flame structure were observed by PIV (Particle Image Velocimetry) and OH PLIF (Planar Laser Induced Fluorescence) measurements respectively. We also could found that internal recirculation of exhausted gases and flow dynamics such as turbulent intensity, strain rate and vorticity were very important in stabilizing the inner flame. To design the high-efficiency and environment-friendly double cooktop burner, CO emission and thermal efficiency must be optimized under circumstances such as regulation limits, customer’s needs and so on.
Neurodevelopment in Early Childhood Affected by Prenatal Lead Exposure and Iron Intake
Shah-Kulkarni, Surabhi,Ha, Mina,Kim, Byung-Mi,Kim, Eunjeong,Hong, Yun-Chul,Park, Hyesook,Kim, Yangho,Kim, Bung-Nyun,Chang, Namsoo,Oh, Se-Young,Kim, Young Ju,Lee, Boeun,Ha, Eun-Hee Wolters Kluwer Health 2016 Medicine Vol.95 No.4
<▼1><P>Supplemental Digital Content is available in the text</P></▼1><▼2><P><B>Abstract</B></P><P>No safe threshold level of lead exposure in children has been recognized. Also, the information on shielding effect of maternal dietary iron intake during pregnancy on the adverse effects of prenatal lead exposure on children's postnatal neurocognitive development is very limited. We examined the association of prenatal lead exposure and neurodevelopment in children at 6, 12, 24, and 36 months and the protective action of maternal dietary iron intake against the impact of lead exposure.</P><P>The study participants comprise 965 pregnant women and their subsequent offspring of the total participants enrolled in the Mothers and Children's environmental health study: a prospective birth cohort study. Generalized linear model and linear mixed model analysis were performed to analyze the effect of prenatal lead exposure and mother's dietary iron intake on children's cognitive development at 6, 12, 24, and 36 months.</P><P>Maternal late pregnancy lead was marginally associated with deficits in mental development index (MDI) of children at 6 months. Mothers having less than 75th percentile of dietary iron intake during pregnancy showed significant increase in the harmful effect of late pregnancy lead exposure on MDI at 6 months. Linear mixed model analyses showed the significant detrimental effect of prenatal lead exposure in late pregnancy on cognitive development up to 36 months in children of mothers having less dietary iron intake during pregnancy.</P><P>Thus, our findings imply importance to reduce prenatal lead exposure and have adequate iron intake for better neurodevelopment in children.</P></▼2>
Iron deficiency increases blood concentrations of neurotoxic metals in children
Kim, Yangho,Park, Sangkyu The Korean Pediatric Society 2014 Clinical and Experimental Pediatrics (CEP) Vol.57 No.8
Iron deficiency affects approximately one-third of the world's population, occurring most frequently in children aged 6 months to 3 years. Mechanisms of iron absorption are similar to those of other divalent metals, particularly manganese, lead, and cadmium, and a diet deficient in iron can lead to excess absorption of manganese, lead, and cadmium. Iron deficiency may lead to cognitive impairments resulting from the deficiency itself or from increased metal concentrations caused by the deficiency. Iron deficiency combined with increased manganese or lead concentrations may further affect neurodevelopment. We recently showed that blood manganese and lead concentrations are elevated among iron-deficient infants. Increased blood manganese and lead levels are likely associated with prolonged breast-feeding, which is also a risk factor for iron deficiency. Thus, babies who are breast-fed for prolonged periods should be given plain, iron-fortified cereals or other good sources of dietary iron.