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RISS 인기검색어
- 검색키워드
- 저자 : ( Wasim Jafri ) (검색결과 2 건)
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Javed Yakoob,Zaigham Abbas,Muhammad Islam,Shahab Abid,Wasim Jafri 거트앤리버 소화기연관학회협의회 2010 Gut and Liver Vol.4 No.3
Background/Aims: Genes associated with the Helicobacter pylori (H. pylori) plasticity region may play a role in the pathogenesis of H. pylori. We compared the genes jhp0940, jhp0947, and jhp0986 in H. pylori isolates from patients with different gastroduodenal diseases and in different age groups. Methods: The H. pylori hyperplasticity region genes jhp0940, jhp0947,and jhp0986 were studied by PCR. We also evaluated whether these genes were related to the cytotoxin-associated gene (cagA) and histology findings. Results: Of the patient cohort, 71 (62%) were positive for jhp0940, 67 (59%) for jhp0947, 12 (10%) for jhp0986, and 69 (60%) for cagA. jhp0940 (n=18,67%) and jhp0947 (n=23, 85%) were found more frequently in duodenal ulcer (DU) patients than in gastritis patients (n=14, 39%; p=0.029 and p<0.001, respectively). Gastric ulcer (GU) was more frequently associated with jhp0940 (17 patients, 77%; p=0.003)than with gastritis (14 patients, 39%). Gastric carcinoma (GC) was more strongly associated with both jhp0940 (22 patients, 76%; p=0.003) and jhp0947 (22patients, 76%; p=0.003) than was gastritis (14 patients,39%). jhp0947 was more frequently associated with chronic active inflammation (58 patients, 87%;p=0.009) than with chronic inflammation (9 patients,13%). Multivariate analysis demonstrated that jhp0947was associated with DU (odds ratio, 6.1; 95% confidence interval, 1.87-20). Conclusions: The genes jhp0947 and jhp0940 were identified in H. pylori isolates from patients with GC and DU, while jhp0940was also isolated from patients with GU. jhp0947 was independently associated with DU.
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Singel Agent DAA in HCV PCR Positive Liver Transplant Patients, Experience from a Developing Country
( Hafiz Abdul Basit Siddiqui ),( Basit Siddiqui ),( Rabeea Azmat ),( Wasim Jafri ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Chronic hepatitis C (CHC) is the leading cause of decom pensated liver disease and liver transplant indication in Pakistan, which is the second most prevalent country with a prevalence of 3.5% to 5.2%. Being the seventh most populous country in the world, lacking significantly on medical grounds reflected by only one liver transplant centre for more than 10 million chron ically affected liver disease patients. Before the era of directly acting antiviral agents (DAAs) most common problem faced in the post liver transplant period was recurrence of HCV and most of the patients were non responders to interferon therapy well before transplantation of liver graft. Aim of this study is to see the outcomes of single agent DAA in HCV PCR positive liver transplant patients. Methods: This cross sectional analysis was carried out in CHC infected post liver transplant patients with high viremia. The effect of DAAs were noted in the form of eradication of virus and achievement of sustained virological response (SVR). DAAs used, were also recored. Also to note the interaction with immunosuppresants and development of side effects notably derangement of liver function test or failure of graft and ane mia. And to note the development of acute kidney injury or any other untoward effect. Results: During study period of 24 months, from January 2015 to December 2016, 51 HCV positive liver transplant patients were enrolled in the study. 26 (52%) out of 51 found to have active viral replication with positive PCR. All 26 received com bination of Sofosbuvir (only DAA avaialbe till December 2016 in Pakistan) and Ribavirin. Achievement of viral eradication was 100% so was for SVR. There was no interaction with immunosuppressants. Most commonly reported side effect was fatigue and a feeling of nausea. Kidney and liver function tests remained normal. Contrary to recent data, there was no recurrence of hepatocellular carcinoma (HCC) in patients who recieved liver graft for HCC on background of CHC cirrhosis. Conclusions: Directly acting antiviral therapy has revolutionized outcomes of HCV infected post liver transplant patients in a country lacking modern and advanced health care system. Even the single agent therapy has done wonders for the economical ly less privileged.
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