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Oh, Sun-Hee,Park, Se-Min,Park, Jong-Sook,Jang, An-Soo,Lee, Yong-Mok,Uh, Soo-Taek,Kim, Young Hoon,Choi, In-Seon,Kim, Mi-Kyeong,Park, Byeong Lae,Shin, Hyoung-Doo,Park, Choon-Sik The Korean Academy of Asthma, Allergy and Clinical 2009 Allergy, Asthma & Immunology Research Vol.1 No.1
<P><B>Purpose</B></P><P>Peroxisome proliferator-activated receptors (PPARs) are transcriptional factors activated by ligands of the nuclear hormone receptor superfamily. The activation of PPARγ regulates inflammation by downregulating the production of Th2 type cytokines and eosinophil function. In addition, a range of natural substances, including arachidonate pathway metabolites such as 15-hydroxyeicosatetranoic acid (15-HETE), strongly promote <I>PPARG</I> expression. Therefore, genetic variants of the <I>PPARG</I> gene may be associated with the development of aspirin-intolerant asthma (AIA). We investigated the relationship between single nucleotide polymorphism (SNP) of the <I>PPARG</I> gene and AIA.</P><P><B>Methods</B></P><P>Based on the results of an oral aspirin challenge, asthmatics (n=403) were categorized into two groups: those with a decrease in FEV<SUB>1</SUB> of 15% or greater (AIA) or less than 15% (aspirin-tolerant asthma, ATA). We genotyped two single nucleotide polymorphisms in the <I>PPARG</I> gene from Korean asthmatics and normal controls (n=449): +<I>34C>G</I> (Pro12Ala) and +<I>82466C>T</I> (His449His).</P><P><B>Results</B></P><P>Logistic regression analysis showed that +<I>82466C>T</I> and haplotype 1 (CC) were associated with the development of aspirin hypersensitivity in asthmatics (<I>P</I>=0.04). The frequency of the rare allele of +<I>82466C>T</I> was significantly higher in AIA patients than in ATA patients in the recessive model [<I>P</I>=0.04, OR=3.97 (1.08-14.53)]. In addition, the frequency of <I>PPARG</I> haplotype 1 was significantly lower in AIA patients than in ATA patients in the dominant model (OR=0.25, <I>P</I>=0.04).</P><P><B>Conclusions</B></P><P>The +<I>82466C>T</I> polymorphism and haplotype 1 of the <I>PPARG</I> gene may be linked to increased risk for aspirin hypersensitivity in asthma.</P>
Oh, Sun-Hee,Kim, Yong-Hoon,Park, Se-Min,Cho, Sung-Hwan,Park, Jong-Sook,Jang, An-Soo,Park, Sung-Woo,Uh, Soo-Taek,Lee, Youg-Mok,Kim, Mi-Kyeong,Choi, Inseon S,Cho, Sang Heon,Hong, Chein-Soo,Lee, Yong Won Ashley Publications 2011 Pharmacogenomics Vol.12 No.3
<P>Aim: Thromboxane A synthase (TBXAS1) converts prostaglandin H to thromboxane A, a potent constrictor of smooth respiratory muscle. Thus, functional alterations of the TBXAS1 gene may contribute to aspirin-intolerant asthma (AIA). Materials & methods: We investigated the relationship between SNPs in the TBXAS1 gene and AIA. Asthmatics (n = 470) were categorized into AIA (20% or greater decreases in forced expiratory volume in 1 s [FEV(1)], or 15% to 19% decreases in FEV(1) with naso-ocular or cutaneous reactions) and aspirin-tolerant asthma (ATA). A total of 101 SNPs were genotyped. mRNA expression of the TBXAS1 gene by peripheral blood mononuclear cells and plasma thromboxane B2 (TXB2) concentrations were measured by reverse transcriptase (RT)-PCR and ELISA. Results: Logistic regression analysis showed that the rare allele frequency of rs6962291 in intron 9 was significantly lower in the AIA group (n = 115) than in the ATA group (n = 270) (p(corr) = 0.04). The linear regression analysis revealed a strong association of rs6962291 with the aspirin challenge-induced FEV(1) fall (p = 0.003). RT-PCR revealed an exon-12-deleted splice variant. We measured TBXAS1 mRNA levels in peripheral blood mononuclear cells. The mRNA levels of the full-length wild-type and splice variant were significantly higher in the TT homozygotes than in the AA homozygotes of rs6962291 (1.00 ± 0.18 vs 0.57 ± 0.03 and 1.00 ± 0.18 vs 0.21 ± 0.05, p = 0.047 and 0.001, respectively). The plasma TXB2 level was significantly lower in rs6962291 AA carriers than in rs6962291 TT (p = 0.016) carriers. Conclusion: The rare allele of rs6962291 may play a protective role against aspirin hypersensitivity via a lower catalytic activity of the TBXAS1 gene, attributed to the increase of a nonfunctioning isoform of TBXAS1. Original submitted 26 August 2010; Revision submitted 29 October 2010.</P>
Different Responses to Clarithromycin in Patients with Cryptogenic Organizing Pneumonia
Oh, Ji Hyun,Oh, Dong Jun,Koo, So-My,Kim, Yang Ki,Kim, Ki Up,Kim, Hyun Jo,Kim, Dong Won,Uh, Soo-Taek The Korean Academy of Tuberculosis and Respiratory 2015 Tuberculosis and Respiratory Diseases Vol.78 No.4
Cryptogenic organizing pneumonia (COP) is an idiopathic interstitial pneumonia characterized by a subacute course and favorable prognosis with corticosteroids. However, some patients show resistance to steroids. Macrolides have been used with success in those patients showing resistance to steroids. A few reports showed treatment failure with macrolides in patients with COP who were resistant to steroids. In this report, we described two cases of COP who showed different responses to clarithromycin. One recovered completely, but the other gradually showed lung fibrosis with clarithromycin.
( Dong Jun Oh ),( So My Koo ),( Yang Ki Kim ),( Ki Up Kim ),( Soo-taek Uh ),( Do Jin Kim ),( Yong Hoon Kim ),( Choon Sik Park ) 대한결핵 및 호흡기학회 2016 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.121 No.-
Background and objectives: There is a debate regarding the level of vitamin D and its impact on lung function in patients with COPD. We evaluated the relationship of vitamin D with lung function and quality of life (QOL) in persons with obstructive airway disease (OAD) in Korea. Methods: The present study was based on the Korean National Health and Nutrition Examination Survey 2010-2014. The plasma level of vitamin D (25-hydroxyvitmain D) was measured by radioimmunoassay. The EuroQol-5D (EQ-5D) index was used to assess the QOL. OAD was defined as less than 0.7 of FEV1/FVC and more than 40 years old. Results: The study population comprised of 1,475 persons with OAD and 9,406 healthy persons. OAD itself was not risk factor for vitamin deficiency after adjustment for sex, age, smoking, and BMI. Vitamin D was correlated with FEV1 pred. % (FEV1%) and FEV1 (p=0.014 and p=0.000, respectively) in persons with OAD. Vitamin D was risk factor for decrease of FEV1% and FEV1 after adjustment for sex, age, smoking, and BMI in persons with OAD. Vitamin D deficiency group (lower than 20 ng/mL) showed lower FEV1 than did non-deficiency group (p=0.005) in persons with OAD. However, vitamin D did not affect any factors of EQ-5D after adjustment of sex, age, BMI, and smoking in persons with OAD. Conclusion: Vitamin D related with decrease of lung function, but not QOL in persons with OAD.