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      • HCC : PE-052 ; Incidence of and risk factors associated with liver abscess formation after radiofrequency ablation

        ( Stephen N Wong ),( Rommel Romano ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-

        Background: Liver abscess formation is an infrequent complication of radiofrequency ablation (RFA). Little is known in the literature about the factors that predispose patients to develop this complication. Objectives: We aimed to report on the incidence of liver abscess formation after RFA, and to analyze risk factors for its development. Methods: From February 1, 2007 to March 31, 2012, consecutive patients undergoing RFA for liver metastasis or hepatocellular carcinoma (HCC) were included into the study. The use of antibiotic prophylaxis was left to the discretion of the attending physician. Results: A total of 144 RFA procedures were included, majority of which was performed in patients with HCC (72.9%). The mean size of the ablated tumors was 4.4 cm. Liver abscess occurred in 5 (3.5%) of the procedures. One liver abscess manifested as an infected cyst beside the ablated tumor and another occurred in a patient with a biliary stent, while the remaining 3 cases did not have obvious risk factors. There was no difference in age, sex, type of needle (single vs. cluster) and type of tumor between patients with and without abscess. Surprisingly, patients given antibiotic prophylaxis had the same abscess incidence (3.9%) as those not given prophylaxis (3.2%) (p=0.827). There was a trend for a higher abscess incidence in tumors >4.5 cm (6.5%) as compared to smaller tumors (1.2%; p=0.089). Conclusions: Liver abscess formation occurs in 3.5% of RFA procedures. The role of antibiotic prophylaxis for the prevention of abscess is not evident in our cohort. A greater sample size is needed to further elucidate risk factors for this complication.

      • LT, Others : PE-129 ; Efficacy of single-session percutaneous ethanol sclerosis in symptomatic benign hepatic cysts

        ( Stephen N. Wong ),( Maria Theresa Nido ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-

        Background: Benign liver cysts require treatment when they become symptomatic. Effective, single-session techniques in percutaneous management of symptomatic cysts are infrequently described in the literature. Objective: To assess the efficacy of single-session percutaneous ethanol sclerotherapy in patients with symptomatic benign hepatic cysts. Methodology: From May 2007-May 2011, consecutive patients with symptomatic benign hepatic cysts were treated with single-session sclerotherapy for 15 minutes using 99.9% ethanol under ultrasound and fluoroscopic guidance. Patients were followed-up with repeat ultrasound at 1 and 6 months after the procedure, then every 6 months thereafter. Patients with at least 1 follow-up ultrasound were included. Results: A total of 19 cysts from 14 patients were included. The mean cyst volume was 588.3±662.3 ml (range=27-2,420 ml). There were 3 (15.8%) hemorrhagic cysts while the rest (84.2%) yielded clear fluid. An average of 72.4±63.5 ml of alcohol (5.7-74.0% of the cyst volume) was injected into each cyst. Median follow-up of the cohort was 262 days (range= 32-809) with 10 (52.6%) patients having at least 2 follow-ups after the procedure. Mean cyst volume reduction was 69.6±26.0% (range=14.4-98.2%) after the first follow-up (p <.001). On last follow-up, there was further cyst volume reduction to 86.4±24.0% (range=24.8-100.0%) (p <.001) with cyst volumes ranging from 0-85.6 ml after treatment. All patients became asymptomatic and only 1 patient needed a repeat procedure because of re-enlargement of the cyst from hemorrhage. Conclusion: Single-session ethanol sclerotherapy is associated with resolution of symptoms and a significant reduction in the volume of symptomatic benign hepatic cysts.

      • HCC : PE-052 ; Incidence of and risk factors associated with liver abscess formation after radiofrequency ablation

        ( Stephen N. Wong ),( Rommel Romano ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1

        Background: Liver abscess formation is an infrequent complication of radiofrequency ablation (RFA). Little is known in the literature about the factors that predispose patients to develop this complication. Objectives: We aimed to report on the incidence of liver abscess formation after RFA, and to analyze risk factors for its development. Methods: From February 1, 2007 to March 31, 2012, consecutive patients undergoing RFA for liver metastasis or hepatocellular carcinoma (HCC) were included into the study. The use of antibiotic prophylaxis was left to the discretion of the attending physician. Results: A total of 144 RFA procedures were included, majority of which was performed in patients with HCC (72.9%). The mean size of the ablated tumors was 4.4 cm. Liver abscess occurred in 5 (3.5%) of the procedures. One liver abscess manifested as an infected cyst beside the ablated tumor and another occurred in a patient with a biliary stent, while the remaining 3 cases did not have obvious risk factors. There was no difference in age, sex, type of needle (single vs. cluster) and type of tumor between patients with and without abscess. Surprisingly, patients given antibiotic prophylaxis had the same abscess incidence (3.9%) as those not given prophylaxis (3.2%) (p=0.827). There was a trend for a higher abscess incidence in tumors >4.5 cm (6.5%) as compared to smaller tumors (1.2%; p=0.089). Conclusions: Liver abscess formation occurs in 3.5% of RFA procedures. The role of antibiotic prophylaxis for the prevention of abscess is not evident in our cohort. A greater sample size is needed to further elucidate risk factors for this complication.

      • LT, Others : PE-129 ; Efficacy of single-session percutaneous ethanol sclerosis in symptomatic benign hepatic cysts

        ( Maria Theresa Nido ),( Stephen N. Wong ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1

        Background: Benign liver cysts require treatment when they become symptomatic. Effective, single-session techniques in percutaneous management of symptomatic cysts are infrequently described in the literature. Objective: To assess the efficacy of single-session percutaneous ethanol sclerotherapy in patients with symptomatic benign hepatic cysts. Methodology: From May 2007-May 2011, consecutive patients with symptomatic benign hepatic cysts were treated with single-session sclerotherapy for 15 minutes using 99.9% ethanol under ultrasound and fluoroscopic guidance. Patients were followed-up with repeat ultrasound at 1 and 6 months after the procedure, then every 6 months thereafter. Patients with at least 1 follow-up ultrasound were included. Results: A total of 19 cysts from 14 patients were included. The mean cyst volume was 588.3±662.3 ml (range=27-2,420 ml). There were 3 (15.8%) hemorrhagic cysts while the rest (84.2%) yielded clear fluid. An average of 72.4±63.5 ml of alcohol (5.7-74.0% of the cyst volume) was injected into each cyst. Median follow-up of the cohort was 262 days (range= 32-809) with 10 (52.6%) patients having at least 2 follow-ups after the procedure. Mean cyst volume reduction was 69.6±26.0% (range=14.4-98.2%) after the first follow-up (p <.001). On last follow-up, there was further cyst volume reduction to 86.4±24.0% (range=24.8-100.0%) (p <.001) with cyst volumes ranging from 0-85.6 ml after treatment. All patients became asymptomatic and only 1 patient needed a repeat procedure because of re-enlargement of the cyst from hemorrhage. Conclusion: Single-session ethanol sclerotherapy is associated with resolution of symptoms and a significant reduction in the volume of symptomatic benign hepatic cysts.

      • HCC : O-010 ; Predictors of viable tumor cells adhering to the electrode after radiofrequency ablation of malignant liver tumors

        ( Erwin Sarapuddin ),( Rommel Romano ),( Rolando Lopez ),( Stephen N Wong ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-

        Background: The presence of viable tumor cells adhering to the radiofrequency ablation (RFA) electrodes during its withdrawal is one possible mechanism for neoplastic seeding and local tumor recurrence. However, this has not been well studied in patients undergoing Cooltip RFA. Objectives: To determine the incidence, and tumor and procedure-related predictors of viable tissue adhering to the RFA electrode during RFA of malignant liver tumors. Methods: From June 2011-October 2011, consecutive patients who underwent RFA using Cooltip electrode for malignant liver tumors at two tertiary hospitals were included. After each RFA application, the electrode tip was examined and scraped and washed in saline. Visible tissue fragments adherent to the electrode were stained with hematoxylin and eosin and analyzed for viability. Specimens were classified as coagulation necrosis, possibly non viable tissue and possibly viable tissue. Results: Majority (90%) of the 10 patients had hepatocellular carcinoma. There were 20 tumors ablated with a mean size of 3.33+1.13, which needed 36 total RFA applications. Adherent tissue was seen in 9 (25%) applications while the rest showed blood only 12 (33.3%) and no adherent tissue 15 (41.7%). Of the 9 tissues examined, 6 (67%) showed possibly viable tissue while the rest (33%) showed coagulation necrosis only. The temperature at the end of RFA was the only significant predictor for the presence of adherent tissue (p=0.005). However, this did not correlate with viability (p 0.314). Conclusion: Viable tumor cells adherent to the RF electrodes was found in 16.7% of applications after RFA with no significant predictors of its incidence.

      • SCOPUSKCI등재
      • HCC : O-010 ; Predictors of viable tumor cells adhering to the electrode after radiofrequency ablation of malignant liver tumors

        ( Erwin Sarapuddin ),( Rommel Romano ),( Rolando Lopez ),( Stephen N. Wong ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1

        Background: The presence of viable tumor cells adhering to the radiofrequency ablation (RFA) electrodes during its withdrawal is one possible mechanism for neoplastic seeding and local tumor recurrence. However, this has not been well studied in patients undergoing Cooltip RFA. Objectives: To determine the incidence, and tumor and procedure- related predictors of viable tissue adhering to the RFA electrode during RFA of malignant liver tumors. Methods: From June 2011-October 2011, consecutive patients who underwent RFA using Cooltip electrode for malignant liver tumors at two tertiary hospitals were included. After each RFA application, the electrode tip was examined and scraped and washed in saline. Visible tissue fragments adherent to the electrode were stained with hematoxylin and eosin and analyzed for viability. Specimens were classified as coagulation necrosis, possibly non viable tissue and possibly viable tissue. Results: Majority (90%) of the 10 patients had hepatocellular carcinoma. There were 20 tumors ablated with a mean size of 3.33+1.13, which needed 36 total RFA applications. Adherent tissue was seen in 9 (25%) applications while the rest showed blood only 12 (33.3%) and no adherent tissue 15 (41.7%). Of the 9 tissues examined, 6 (67%) showed possibly viable tissue while the rest (33%) showed coagulation necrosis only. The temperature at the end of RFA was the only significant predictor for the presence of adherent tissue (p=0.005). However, this did not correlate with viability (p 0.314). Conclusion: Viable tumor cells adherent to the RF electrodes was found in 16.7% of applications after RFA with no significant predictors of its incidence.

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