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Park Yoojin,Huh In Sil,Lee Jaekyung,Kang Cho Ryok,조성일,Ham Hyon Jeen,Kim Hea Sook,Kim Jung-il,나백주,Lee Jin Yong,Seoul Metropolitan Government COVID-19 Rapid Response (SCoRR) Team 대한의학회 2020 Journal of Korean medical science Vol.35 No.45
Background: Following the coronavirus disease 2019 (COVID-19) outbreak in Wuhan, China, a total of 637 patients had been diagnosed with the disease in Seoul as of May 2, 2020. Our study aimed to describe the impact of the 3T strategies (preemptive testing, prompt tracing and proper treatment) on the epidemiological characteristics of COVID-19 in Seoul. Methods: The descriptive and explanatory analysis was carried out on critical indicators such as epidemiological characteristics and key duration of patient status change from January 24 to May 2 in Seoul before and after preemptive testing for patients under investigation associated with COVID-19 clusters. Results: Preemptive testing increased the positive test rate (3.9% to 4.2%), an asymptomatic case at diagnosis (16.9% to 30.6%), and reduced the time from symptom onset to quarantine (4.0 to 3.0 days). Prompt tracing decreased unknown sources of infection (6.9% to 2.8%), the mean number of contacts (32.2 to 23.6), and the time-varying reproduction number R(t) (1.3 to 0.6). With proper treatment, only 2 cases of mortality occurred, resulting in a fatality rate of just 0.3%. Conclusion: In the first wave of the COVID-19 pandemic lasting 100 days, the effect of the 3T strategies flattened the curve and decreased the time during which infected individuals were contagious, thereby lowering the R(t) below 1 in Seoul.
Lee Seoul,Ahn Seon Ho,Baek Seung Hoon,Song Ju Hung,Choo Young Kug,Kwon Oh Deog,Choi Bong Kyu,Jung Kyu Yong The Pharmaceutical Society of Korea 2005 Archives of Pharmacal Research Vol.28 No.8
Glomerular mesangial cells (GMCs) in diverse renal diseases undergo cell proliferation and/or hypertrophy, and gangliosides have been reported to play an important role in modulating cell structure and function. This study compared the effects of transforming growth $factor-\beta\; (TGF\beta1)$ and the effects of the application of exogenous gangliosides on GMCs and investigated whether the application of exogenous gangliosides regulated cellular proliferation and hypertrophy. Human GMCs were cultured with exogenous gangliosides and $TGF-\beta1$ in a media containing $10\%$ fetal bovine serum and in a media without the fetal bovine serum. Exogenous gangliosides biphasically changed the proliferation of human GMCs (0.1-1.0 mg/mL). A low concentration (0.1 mg/mL) of gangliosides mainly increased the number of human GMCs, whereas cellular proliferation was significantly reduced by raising the concentration of exogenous gangliosides. $TGF-\beta1$ greatly reduced the number of human GMCs in a concentrationdependent manner (1-10 ng/mL). Serum deprivation accelerated the gangliosides- and $TGF\beta1-induced$ inhibition of mesangial cell proliferation to a greater extent. Gangliosides (1.0 mg/ mL) and $TGF-\beta1$ (10 ng/mL) both caused a significant increase in the incorporation of $[^3H]leucine$ per cell in the serum-deprived condition, whereas it was completely reversed in serumsupplemented condition. Similar results to the $[^3H]leucine$ incorporation were also observed in the changes in cell size measured by flow cytometric analysis. These results show that exogenous gangliosides modulate cell proliferation and hypertrophy in cultured human GMCs, and these cellular responses were regulated differently based on whether the media contained serum or not. Results from the present study raise new possibilities about the potential involvement of gangliosides in the development of mesangial cell proliferation and hypertrophy.
Lee, Jun Ho,Kwon, Oh Deog,Ahn, Seon Ho,Choi, Keun Han,Park, Ji Hye,Lee, Seoul,Choi, Bong Kyu,Jung, Kyu Yong WJG Press 2012 WORLD JOURNAL OF GASTROENTEROLOGY Vol.18 No.33
<P>To investigate whether the combined methods of unilateral thyroparathyroidectomy (TPX) and subdiaphragmatic vagotomy (VAX) can be adapted for rats and used as a reliable method to produce a rat model of long-term reduction of gastrointestinal (GI) motor function.</P>
Atmospheric Pressure Plasma Jet Composed of Three Electrodes: Application to Tooth Bleaching
Lee, Hyun Woo,Nam, Seoul Hee,Mohamed, Abdel-Aleam H.,Kim, Gyoo Cheon,Lee, Jae Koo WILEY-VCH Verlag 2010 Plasma Processes and Polymers Vol.7 No.3
<P>Three-electrode plasma jet system consisting of a perforated dielectric tube with two outer and one floating inner electrodes was developed and employed for tooth bleaching. Lowered gas breakdown voltage and increased discharge current were achieved by using the floating inner electrode. Optical emission spectra analysis showed that the rotational temperature of the second positive nitrogen bands was ≈290 K and vibrational temperature was ≈2 500 K, which means this plasma is in highly non-quilibrium state and nonthermal. The presence of excited He, N<SUB>2</SUB>, N<EM><SUB>2</SUB><SUP>+</SUP></EM> and O in the plasma plume was revealed. The plasma jet was used in combination with hydrogen peroxide (H<SUB>2</SUB>O<SUB>2</SUB>) to remove stains from extracted teeth stained by either coffee or red wine. Combining the plasma jet and H<SUB>2</SUB>O<SUB>2</SUB> improved the bleaching efficacy by a factor of 3.1 (coffee) and 3.7 (red wine) compared with using H<SUB>2</SUB>O<SUB>2</SUB> alone.</P><P> <img src='wiley_img_2010/16128850-2010-7-3-4-PPAP200900083-gra001.gif' alt='wiley_img_2010/16128850-2010-7-3-4-PPAP200900083-gra001'> </P> <B>Graphic Abstract</B> <P>An atmospheric pressure plasma jet has attracted great interest in biomedical applications thanks to its simplicity of the design and its diverse capabilities. This study proposed a design of a safe and reactive, nonthermal atmospheric pressure plasma jet, and demonstrated that the plasma jet enhanced the tooth bleaching effect. We expect that this study can contribute to widening the application field of atmospheric pressure plasma. <img src='wiley_img_2010/16128850-2010-7-3-4-PPAP200900083-content.gif' alt='wiley_img_2010/16128850-2010-7-3-4-PPAP200900083-content'> </P>
Seoul Lee,Seon Ho Ahn,Seung Hoon Baek,Ju Hung Song,Young Kug Choo,Oh Deog Kwon,Bong Kyu Choi,Kyu Yong Jung 대한약학회 2005 Archives of Pharmacal Research Vol.28 No.8
Glomerular mesangial cells (GMCs) in diverse renal diseases undergo cell proliferation and/or hypertrophy, and gangliosides have been reported to play an important role in modulating cell structure and function. This study compared the effects of transforming growth factor-β1 (TGF- β1) and the effects of the application of exogenous gangliosides on GMCs and investigated whether the application of exogenous gangliosides regulated cellular proliferation and hypertrophy. Human GMCs were cultured with exogenous gangliosides and TGF-β1 in a media containing 10% fetal bovine serum and in a media without the fetal bovine serum. Exogenous gangliosides biphasically changed the proliferation of human GMCs (0.1-1.0 mg/mL). A low concentration (0.1 mg/mL) of gangliosides mainly increased the number of human GMCs, whereas cellular proliferation was significantly reduced by raising the concentration of exogenous gangliosides. TGF-β1 greatly reduced the number of human GMCs in a concentrationdependent manner (1-10 ng/mL). Serum deprivation accelerated the gangliosides- and TGF- β1-induced inhibition of mesangial cell proliferation to a greater extent. Gangliosides (1.0 mg/ mL) and TGF-β1 (10 ng/mL) both caused a significant increase in the incorporation of [3H]leucine per cell in the serum-deprived condition, whereas it was completely reversed in serumsupplemented condition. Similar results to the [3H]leucine incorporation were also observed in the changes in cell size measured by flow cytometric analysis. These results show that exogenous gangliosides modulate cell proliferation and hypertrophy in cultured human GMCs, and these cellular responses were regulated differently based on whether the media contained serum or not. Results from the present study raise new possibilities about the potential involvement of gangliosides in the development of mesangial cell proliferation and hypertrophy.