양악 편측에 발생한 다발성 함치성 낭종의 치험례

김기백,김선미,양규효,최남기 大韓小兒齒科學會 2009 大韓小兒齒科學會誌 Vol.36 No.2

Dentigerous cysts generally encompass the crown of an unerupted tooth. These cysts are usually solitary. They are the second most common odontogenic type of cysts following radicular cysts, and are frequently associated with impacted mandibular third molars or maxillary canines. Most multiple cysts found in the jaw are odontogenic keratocysts associated with the nevoid basal cell carcinoma syndrome, mucopolysaccharidoses and cleidocranial dysplasia. Although a single dentigerous cyst is well documented in the medical literature, including the prevalence, treatment and prognosis, multiple dentigerous cysts without any systemic symptoms is unusual. Furthermore, cases involving both the maxilla and mandible are especially rare. We present the case of an 11-year-old boy with nonsyndromic multiple dentigerous cysts associated with a mandibular second premolar and a maxillary canine. The treatment was conservative and included marsupialization and eruption guidance. Further follow up is planned to rule out additional problems and the possible identification of a syndrome. 함치성 낭종은 일반적으로 미맹출 치아의 치관을 포함하고 있는 형태로, 치아 법랑질과 이장 상피 사이에 액체가 축적되어 생긴 잔존 법랑 상피조직의 퇴행성 변화로 부터 생긴다. 치근단 낭 다음으로 가장 흔한 치성 낭종으로, 주로 단독으로 발생하고 하악 제 3대구치와 상악 소구치에 호발한다. 악골의 다발성 낭종은 주로 기저세포 모반증후군과 관련된 치성 각화낭이 대부분이고, 점액다당류증 또는 쇄골두개 이형성증과도 관련이 있을 수 있다. 단발성의 함치성 낭종은 우리에게 친숙할 정도로 유병율에서 치료 및 예후까지 잘 알려져 있으나, 전신병력이 없는 다발성의 함치성 낭종은 드물며, 상악과 하악에 발생한 다발성 낭종은 특히 더 드물다. 본 증례는 편측성으로 양악에 함께 발생한 다발성의 함치성 낭종을 가진 11세 소년에 대한 치료 증례로 1년간의 관찰 후 양호할만한 결과를 얻었기에 보고하는 바이다. 1년이라는 관찰 기간이 짧기 때문에 향후 지속적인 임상적, 방사선적 관찰을 필요로 하리라 사료된다.

미성숙 상악 연구 중철치에서의 치근파절 치험례

김기백,김선미,최남기,양규호 대한소아치과학회 2007 大韓小兒齒科學會誌 Vol.34 No.3

수종의 밴드 접착 시멘트의 물성에 대한 비교 연구

양규호,김기백,김선미,최남기 大韓小兒齒科學會 2009 大韓小兒齒科學會誌 Vol.36 No.3

본 연구의 목적은 시중에 유통되고 있는 밴드 시멘트들을 종류별로 이용하여 교정용 밴드의 결합강도를 비교하고, 각 시멘트의 파절 양상을 비교하여 교정용 밴드에 대한 사용지침을 마련하는데 도움이 되고자 하였다. 100개의 발거된 인간의 제 3대구치를 이용해 실험군은 총 5개의 군으로 하였으며, 각 군당 시편수가 20개가 되도록 임의적으로 분류하였다. 실험에 사용한 밴드 시멘트는 다음과 같다; Ormco gold, Ultra Band-Lo™, Fuji Ortho™ LC, 3M Unitek™ Multi-Cure Glass Ionomer, Ketac-Cem™. Universal testing machine(Instron Corp., Canton, MA, USA)를 사용하여 최대하중값을 측정하였고, 전단결합강도 값을 계산하였다. 밴드가 탈락한 후, 탈락부위를 평가하여 법랑질과 시멘트, 시멘트와 밴드 사이로 구분하였다. 밴드의 전단강도는 One-way ANOVA를 이용하여 통계처리 하였으며 Tukey test를 이용하여 검정하였다. 또한 탈락 부위는 Chi-squre analysis를 이용하여 통계 처리하였고, Fisher's exact test로 군간 유의성을 검정하였다. 실험 결과 평균 파절 강도는 Ormco군이 가장 높았고(2.44±0.57), Fuji Ortho™군(2.24±0.50), Ketac-Cem™군(2.10±0.57), 3M Unitek™군(1.82±0.43), Band-Lok™군(1.73±0.28) 순이었으며, Ormco군은 Band-Lok™군과 3M Unitek™군, Fuji Ortho™군은 Band Lok™군과만 통계적으로 유의할만한 차이를 보였다(p<0.05). 파절 양상에서 Ormco군과 Band-Lok™군은 서로뿐만 아니라 다른 군과 유의할만한 차이를 보였으며, Fuji Ortho™, 3M Unitek™, Ketac-Cem™군 간에는 유의한 차이가 없었다. The aim of this study was to compare the shear-peel strength and the fracture site of 5 commercially available orthodontic band cements. One hundred molar bands were cemented to extracted human 3rd molars. The specimens were prepared in accordance with the manufacturer's instructions for each cement. After storage in a humidor at 37℃ for 24 hours. the shear debonding force was assessed for each specimen using an universal testing machine with crosshead speed of 2 mm/minute. Maximal failure stress was converted to mean shear-peel strength. MPa. The predominant site of band failure was recorded visually for all specimens as either at the band/cement or cement/enamel interface. Mean shear-peel strength of Ormco was the highest(2.44±0.57). followed by Fuji Ortho™(2.24±0.50), Ketac-Cem™(2.10±0.57). 3M Unitek™(1.82±0.43). Band-Lok™(1.73±0.28). There were statistically significant differences between Ormco and Band-Lok™. Ormco and 3M Unitek™. and Fuji Ortho™ and Band-Lok™(p<0.05). The predominant site of bonding failure for bands cemented with the Ormco was at the band/cement interface. whereas bands cemented with Ultra Band-Lok™ failed predominantly at the enamel/cement interface. There was no significant difference among the other cements(Fuji Ortho™. 3M Unitek™. Ketac-Cem™).

정상교하 아동의 두개안면부 성장에 관한 종적 연구

양규호,박창헌,손정수,김낙현,최남기,김선미,김기백,신혜성 大韓小兒齒科學會 2009 大韓小兒齒科學會誌 Vol.36 No.3

혼합치열기 정상교합 아동 24명(남:14명 여:10명 초진 시 평균 나이 9±1.3세, 평균 관찰 기간: 13±1.3개월)에 대한 성장량을 측정하여 기능적 교정장치의 순수 치료효과를 평가하는데 도움이 되기 위해 3회(5~8개월 간격) 촬영한 측모 두부 방사선 규격 사진에 대한 분석 결과 다음과 같은 결론을 얻었다. 1. 남아는 상악골은 전하방, 하악골은 전방성장하였고, 여아는 상하악골이 전하방 성장하였다(p<0.05). 2. 상하악골의 남녀간 차이에서 수평적 성장상태는 여아가 컸고(A point 여아: 2.39mm, 남아: 1.26mm, p<0.05), 수직적 성장상태는 유의한 차이가 없었다. 3. 상악 전치의 치축은 두개저에 대해서 순측 경사하였고(p<0.01) 하악 전치의 치축은 큰 변화가 없었다. The purpose of this study was to provide the reference data evaluating the treatment effect of orthopedic appliances. The skeletal and dental growth increments were measured in 24 normal mixed dentition children(boys: 14, girls: 10) by three serial lateral cephalograms: initial mean age: 9±1.3 years, mean observation period: 13±1.3 months, Cephalometric changes were analysed. The results were as follows: 1. In boys, the maxilla showed forward and downward growth pattern and the mandible showed forward growth pattern(p<0.05). In girls, the maxilla and mandible showed forward and downward growth pattern(p<0.05). 2. Horizontal growth of both maxilla and mandible in girls was superior to those in boys(A point: girls: 2.39mm, boys: 1.26mm, with p<0.05), whereas vertical growth of both maxilla and mandible in boys was similar to those in girls. 3. The change in tooth axis showed labioversion of upper incisor(p<0.01) and comparatively stable lower incisor position.

Pro-Apoptotic Activity of 4-Isopropyl-2-(1-Phenylethyl) Aniline Isolated from Cordyceps bassiana

( Mi Seon Kim ),( Yun Mi Lee ),( Gi Ho Sung ),( Ji Hye Kim ),( Jae Gwang Park ),( Han Gyung Kim ),( Kwang Soo Baek ),( Jae Han Cho ),( Jae Gu Han ),( Kang Hyo Lee ),( Sung Youl Hong ),( Jong Hoon Kim 한국응용약물학회 2015 Biomolecules & Therapeutics(구 응용약물학회지) Vol.23 No.4

Cordyceps species including Cordyceps bassiana are a notable anti-cancer dietary supplement. Previously, we identified several compounds with anti-cancer activity from the butanol fraction (Cb-BF) of Cordyceps bassiana. To expand the structural value of Cb-BF-derived anti-cancer drugs, we employed various chemical moieties to produce a novel Cb-BF-derived chemical derivative, KTH-13-amine-monophenyl [4-isopropyl-2-(1-phenylethyl) aniline (KTH-13-AMP)], which we tested for anti-cancer activity. KTH- 13-AMP suppressed the proliferation of MDA-MB-231, HeLa, and C6 glioma cells. KTH-13-AMP also dose-dependently induced morphological changes in C6 glioma cells and time-dependently increased the level of early apoptotic cells stained with annexin V-FITC. Furthermore, the levels of the active full-length forms of caspase-3 and caspase-9 were increased. In contrast, the levels of total forms of caspases-3, caspase-8, caspase-9, and Bcl-2 were decreased in KTH-13-AMP treated-cells. We also confirmed that the phosphorylation of STAT3, Src, and PI3K/p85, which is linked to cell survival, was diminished by treatment with KTH-13- AMP. Therefore, these results strongly suggest that this compound can be used to guide the development of an anti-cancer drug or serve as a lead compound in forming another strong anti-proliferative agent.

체외수정시술을 받는 여성에서 평균 신체활동량과 6개월 내 임신 성공 여부: 전향적 난임부부 코호트 연구

안선미 ( Seon Mi An ),최승아 ( Seung-ah Choe ),전병율 ( Byungyool Jun ) 한국모자보건학회 2021 한국모자보건학회 학술대회 연제집 Vol.2021 No.2

VR 컨트롤러의 모멘트 변화에 따른 최소 무게 차이 인지에 관한 연구

백미선(Mi-Seon Baek),김헌(Huhn Kim) 한국게임학회 2020 한국게임학회 논문지 Vol.20 No.1

본 연구는 가상 물체의 무게감을 사용자에게 전달하여 몰입감 있는 가상현실 경험을 제공하는 컨트롤러에 관한 것이다. 무게감 전달의 수단으로 컨트롤러 내 무게 중심의 위치를 변화시키면 모멘트의 크기가 변화하는 개념을 활용하였다. 사용자가 무게차를 인지하는 무게 중심의 최소이동거리를 알아보기 위해 무게 중심의 위치를 변경할 수 있는 실험 장치를 제작하여 실험을 수행하였다. 그 결과, 시작 자극의 위치와 무관하게 약 5cm의 무게부 거리 차에서 두 물체 간의 무게 차이를 인지하는 것으로 나타났다. 향후 이러한 실험 결과를 반영하여 모멘트 변화에 따른 무게 인지의 최소이동거리 역치 값을 찾는 실험을 수행할 것이다. This study is about the VR controller that can provide an enhanced experience in VR by augmenting the sense of weight. In this study, the method of changing the center of gravity of the controller was used as a means of transmitting the sense of weight. The experiment was carried out with a device that could change the center of gravity to find the minimum distance at which people can perceive the difference in weight. The results showed that the weight difference between the two stimuli can be perceived at a distance of about 5 cm regardless of the position of the starting stimulus.

『해동고승전』을 통해 본 각훈의 고구려 불교사 인식 : 논문

백미선(Baek, Mi-seon) 한국사학사학회 2011 韓國史學史學報 Vol.0 No.23

승려 각훈이 찬술한 『해동고승전』은 『삼국사기』, 『삼국유사』와 함께 삼국시대를 다룬 현존하는 사료로서 매우 중요한 의미를 지난다. 특히 삼국에 불교를 유통시키는데 힘쓴 승려들의 전기를 다룬 덕분에 삼국의 불교사전개 양상과 함께 고려시대에 그 전개 양상을 어떻게 인식하였는지를 살필 수 있다는 점에서 그 가치는 매우 높다고 하겠다. 이 글에서는 그 가운데 『해동고승전』에 수록된 고구려 불교와 관련된 승려들의 전기를 살펴보았다. 그 결과, 각훈은 여러 사서와 승전의 내용을 저본으로 하였지만, 윤색, 절삭 등의 방법을 통해 그 내용을 변형하여 고구려 불교사를 어떻게 인식하고 있는지 드러내었음을 알 수 있었다. 이러한 각훈의 서술 태도를 통해서 그가 고구려 불교사를 어떻게 인식하였는지 알 수 있었다. 각훈은 순도에 의해 고구려가 수용됨으로써 불교가 시작되었다고 보았지만, 한편으로는 그 기저에 이전부터 형성되었던 불교와의 인연이 있었기에 가능했다고 하였다. 이렇게 기반이 되는 인연을 통해서 의연이 북제의 법상에게서 답을 구해올 수 있었고, 이를 통해 고구려에 불교가 막힘없이 유통될 수 있었던 것으로 보았다. 또한, 『해동고승전』의 고구려 불교 관련 사료는 사학사적으로도 많은 의미를 갖는다. 현존하는 사료 가운데 유일하게 삼국 불교와 관련한 승려들의 전기를 전하는 승전으로, 특히 고구려 불교와 관련한 승려의 전기가 이렇게 본격적으로 다뤄진 것은 『해동고승전』이 처음이다. 특히 각훈이 『해동고승전』을 찬술한 시기는 무인정권기에 해당한다. 때문에 그의 찬술 내용에는 당시의 현실에 대한 인식도 반영되었을 것이다. 그가 『해동고승전』에 수록한 고구려 불교 관련 승려들은 모두 나라에 불교가 유통하도록 힘쓰거나, 위험 속에서 불교를 보호하고자 했던 모범적인 인물들이었다. 아마도 각훈은 어지럽던 당시에 이들을 모범으로 삼았으면 하고자 하였던 것은 아닐까 한다. Buddhist monk Gakhoon-authored 〈Haedongkoseungjeon〉 has a very important significance as the extant historical sources dealing with the period of the Three States together with ‘The Chronicles of the Three States’ and ‘The Heritage of the Three States’, especially high in its value in that we are able to look at how the people in the period of Goryeo were aware of the developmental aspects of the history of Buddhism together with the development aspects of the history of Buddhism of the Three States thanks to the Buddhist monks who dedicated themselves to propagating Buddhism to the Three States. This writing specifically took a look at the biography of the Buddhist monks involved in the Buddhism of Goguryeo included in Haedongkoseungjeon〉. As a result, this writer was able to discover that Buddhist monk Gakhoon exposed how he was aware of the history of Buddhism of Goguryeo by modifying the contents of several history books & biographies of Buddhist monks through the use of embellishment and cutting though he based his book 〈Haedongkoseungjeon〉on the contents of several history books & biographies of Buddhist monks as original copies. Through such a statement attitude of Gakhoon, this writer could know how he recognized the history of Buddhism of Goguryeo, Gakhoon seems to have a judgement that the Buddhism in Goguryeo began with Goguryeo’s reception of Buddhism through the propagation of Buddhist monk Sundo, but some were of another opinion that it was possible for Goguryeo to accept Buddhism due to the previously-formed ties with Buddhism at the bottom of the beginning of Buddhism: in addition, they thought that through the foundational ties with Buddhism, a high priest Uiyeon was able to get an answer from the Buddhist teachings in ancient Bukjae Dynasty in China, through which Buddhism could be spread without any block. Further, the historical records related to Buddhism in Goguryeo included in 〈Haedongkoseungjeon〉 have a lot of meanings even from the viewpoint of historical studies. It is the only biography of Buddhist monks delivering the life stories of the Buddhist monks involved in the Buddhism in he Three States among the extant historical records: especially. 〈Haedongkoseungjeon〉 was the first to deal with the biographies of Buddhist monks involved in Buddhism in Goguryeo in earnest like this. The period when Gakhoon wrote 〈Haedongkoseungjeon〉 belongs to the period of military subjects’ dictatorial regime in Goryeo. Therefore, there might be a reflection of the reality at that time in its contents. 〈Haedongkoseungjeon〉-included Buddhist monks related to Buddhism in Goguryeo were the exemplary figures who strove to propagate Buddhism into the country or tried to protect Buddhism from danger with one accord. This writer wonders if Gakhoon might wish the people living in such a turbulent period should follow the example of these monks.

Evaluation of Barley and Wheat Germplasm for Resistance to Head Blight and Mycotoxin Production by Fusarium asiaticum and F. graminearum

Seul Gi Baek(Seul Gi Baek),Jin Ju Park(Jin Ju Park),Sosoo Kim(Sosoo Kim),Mi-Jeong Lee(Mi-Jeong Lee),Ji-Seon Paek(Ji-Seon Paek),Jangnam Choi(Jangnam Choi),Ja Yeong Jang(Ja Yeong Jang),Jeomsoon Kim(Jeom 한국식물병리학회 2022 Plant Pathology Journal Vol.38 No.6

Fusarium head blight (FHB) is one of the most serious diseases in barley and wheat, as it is usually accompanied by the production of harmful mycotoxins in the grains. To identify FHB-resistant breeding resources, we evaluated 60 elite germplasm accessions of barley (24) and wheat (36) for FHB and mycotoxin accumulation. Assessments were performed in a greenhouse and five heads per accession were inoculated with both Fusarium asiaticum (Fa73, nivalenol producer) and F. graminearum (Fg39, deoxynivalenol producer) strains. While the accessions varied in disease severity and mycotoxin production, four wheat and one barley showed <20% FHB severity repeatedly by both strains. Mycotoxin levels in these accessions ranged up to 3.9 mg/ kg. FHB severity was generally higher in barley than in wheat, and Fa73 was more aggressive in both crops than Fg39. Fg39 itself, however, was more aggressive toward wheat and produced more mycotoxin in wheat than in barley. FHB severity by Fa73 and Fg39 were moderately correlated in both crops (r = 0.57/0.60 in barley and 0.42/0.58 in wheat). FHB severity and toxin production were also correlated in both crops, with a stronger correlation for Fa73 (r = 0.42/0.82 in barley, 0.70 in wheat) than for Fg39.

Differences in 25-hydroxy vitamin D and vitamin D-binding protein concentrations according to the severity of endometriosis

Baek, Jong Chul,Jo, Jae Yoon,Lee, Seon Mi,Cho, In Ae,Shin, Jeong Kyu,Lee, Soon Ae,Lee, Jong Hak,Cho, Min-Chul,Choi, Won Jun The Korean Society for Reproductive Medicine 2019 Clinical and Experimental Reproductive Medicine Vol.46 No.3

Objective: To investigate serum 25-hydroxyl vitamin D (25(OH)D) and vitamin D-binding protein (VDBP) concentrations in women with endometriosis according to the severity of disease. Methods: Women with mild endometriosis (n = 9) and advanced endometriosis (n = 7), as well as healthy controls (n = 16), were enrolled in this observational study. Serum total 25(OH)D concentrations were analyzed using the Elecsys vitamin D total kit with the Cobas e602 module. Concentrations of bioavailable and free 25(OH)D were calculated. Concentrations of VDBP were measured using the Human Vitamin D BP Quantikine ELISA kit. Variables were tested for normality and homoscedasticity using the Shapiro-Wilk test and Leven F test, respectively. Correlation analysis was used to identify the variables related to total 25(OH)D and VDBP levels. To assess the effects of total 25(OH)D and VDBP levels in the three groups, multivariate generalized additive modeling (GAM) was performed. Results: Gravidity and parity were significantly different across the three groups. Erythrocyte sedimentation rate (ESR) and CA-125 levels increased as a function of endometriosis severity, respectively (p= 0.051, p= 0.004). The correlation analysis showed that total 25(OH)D levels were positively correlated with gravidity (r = 0.59, p< 0.001) and parity (r = 0.51, p< 0.003). Multivariate GAM showed no significant relationship of total 25(OH)D levels with EMT severity after adjusting for gravidity and ESR. However, the coefficient of total 25(OH)D levels with gravidity was significant (1.87; 95% confidence interval, 0.12-3.63; p= 0.040). Conclusion: These results indicate that vitamin D and VDBP levels were not associated with the severity of endometriosis.