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Short Communications : A New Phenolic Glycoside from Bridelia cambodiana
Piseth Khiev,Young Won Chin,Xing Fu Cai,Hyeong Kyu Lee,Hyouk Joung,Sei Ryang Oh 한국응용생명화학회 2010 Applied Biological Chemistry (Appl Biol Chem) Vol.53 No.2
A new phenolic glycoside, 5-hydroxy-3-methoxyphenyl-6-O-syringoyl-β-D-glucoside (1), was isolated from the n-BuOH-soluble fraction of Bridelia cambodiana along with three known phenolic glycosides. The structures of the isolates were determined on the basi
Cytotoxic Terpenoids from the Methanolic Extract of Bridelia cambodiana
Piseth Khiev,Xing-Fu Cai,Young-Won Chin,Kyung-Seop Ahn,Hyeong-Kyu Lee,오세량 한국응용생명화학회 2009 Applied Biological Chemistry (Appl Biol Chem) Vol.52 No.6
Bioactivity-guided isolation of Bridelia cambodiana, with a cytotoxicity assay using a small panel of cancer cell lines, led to the isolation and identification of five active compounds, 24-methyllanosta- 9(11),25-dien-3β-ol, 3-epi-glutinol, betulinic acid, ursolic acid, and maslinic acid, along with eight triterpenoids and three steroids.
Cytotoxic Terpenoids from the Methanolic Extract of Bridelia cambodiana
( Piseth Khiev ),( Xing Fu Cai ),( Young Won Chin ),( Kyung Seop Ahn ),( Hyeong Kyu Lee ),( Sei Ryang Oh ) 한국응용생명화학회 2009 Applied Biological Chemistry (Appl Biol Chem) Vol.52 No.6
Bioactivity-guided isolation of Bridelia cambodiana, with a cytotoxicity assay using a small panel of cancer cell lines, led to the isolation and identification of five active compounds, 24-methyllanosta-9(11),25-dien-3β-ol, 3-epi-glutinol, betulinic acid, ursolic acid, and maslinic acid, along with eight triterpenoids and three steroids.
Piseth Khiev,Sei-Ryang Oh,Jae Wha Kim,Song Jae Sung,Hyuk-Hwan Song,Dong-Ho Choung,Young-Won Chin,Hyeong-Kyu Lee 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.9
A new ingenane-type diterpene, (3S,5R)5-O-(2,3-dimethylbutanoyl)-13-O-dodecanoyl-20-O-deoxyingenol (1), and six known compounds,3-O-(2,3-dimethylbutanoyl)-13-O-dodecanoyl-20-O-deoxyingenol (2), 20-O-decanoylingenol (3), 20-O-acetylingenol-3-O-(2'E,4'Z) decadienoate (4), kansuiphorin A (5), 3-O-(2,3-dimethylbutanoyl)-13-O-dodecanoylingenol (6), and kansuinin F (7) were isolated and evaluated for their effect on IFN-γ production in NK92 cells. Interestingly, subjection to compounds 4 and 6 (10 nM) displayed the most significant response in IFN-γ production,comparable to that produced by the same dose of phorbol 12-myistate 13-acetate (PMA). High doses of compounds 3 (100 nM), 1 (1.25 μM) and 5 (5.0 μM) have also been shown to activate the IFN-γ production.
Cytotoxic Terpenoids from the Methanolic Extract of Bridelia cambodiana
Khiev, Piseth,Cai, Xing-Fu,Chin, Young-Won,Ahn, Kyung-Seop,Lee, Hyeong-Kyu,Oh, Sei-Ryang The Korean Society for Applied Biological Chemistr 2009 Applied Biological Chemistry (Appl Biol Chem) Vol.52 No.6
Bioactivity-guided isolation of Bridelia cambodiana, with a cytotoxicity assay using a small panel of cancer cell lines, led to the isolation and identification of five active compounds, 24-methyllanosta-9(11),25-dien-3${\beta}$-ol, 3-epi-glutinol, betulinic acid, ursolic acid, and maslinic acid, along with eight triterpenoids and three steroids.
A New Phenolic Glycoside from Bridelia cambodiana
Khiev, Piseth,Chin, Young-Won,Cai, Xing-Fu,Lee, Hyeong-Kyu,Joung, Hyouk,Oh, Sei-Ryang The Korean Society for Applied Biological Chemistr 2010 Applied Biological Chemistry (Appl Biol Chem) Vol.53 No.2
A new phenolic glycoside, 5-hydroxy-3-methoxyphenyl-6-O-syringoyl-$\beta$-D-glucoside (1), was isolated from the n-BuOH-soluble fraction of Bridelia cambodiana along with three known phenolic glycosides. The structures of the isolates were determined on the basis of NMR ($^1H,\;^{13}C$, HSQC, HMBC) and chemical method. All the compounds were tested for their antioxidant activity in a DPPH antioxidant assay.
Chae, Hee-Sung,Khiev, Piseth,Lee, Hyeong-Kyu,Oh, Sei-Ryang,Chin, Young-Won Informa Healthcare 2012 IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY Vol.34 No.4
<P><I>Cinnamomum cambodianum</I> has been used as a traditional medicine in Cambodia. Its effect on the bone marrow-derived mast cells (BMMCs) mediated allergic response remains unknown. In this study, a chloroform-soluble extract of <I>C. cambodianum</I> was evaluated for its effect on allergic mediators, including prostaglandin D<SUB>2</SUB> (PGD<SUB>2</SUB>), leukotriene C<SUB>4</SUB> (LTC<SUB>4</SUB>), β-hexosaminidase and cyclooxygenase-2 (COX-2) protein, in phorbol 12-myristate 13-acetate (PMA) plus calcimycin-stimulated BMMCs. The results revealed that the chloroform-soluble extract inhibited the production of interleukin-6, PGD<SUB>2</SUB> and LTC<SUB>4</SUB>, and the expression of COX-2 in PMA plus calcimycin-stimulated BMMCs, implying a potential benefit of <I>C. cambodianum</I> in the treatment of allergy.</P>
Flavonoids from Thyrsanthera suborbicularis and Their NO Inhibitory Activity
Hyuk-Hwan Song,Piseth Khiev,채희성,Hyeong-Kyu Lee,Sei-Ryang Oh,최영희,진영원 한국생약학회 2012 Natural Product Sciences Vol.18 No.4
Further phytochemical investigation on the whole plant of Thyrsanthera suborbicularis, collected in Cambodia, led to kaempferol (1), vitexin (2), apigenin-7-O-neohesperidoside (3), chrysoeriol-7-O-b-D-glucopyranoside (4), isorhamnetin 3-O-rutinoside (5), kaempferol-3-O-[a-L-rhamnopyranosyl-(13)-a-L-rhamnopyranosyl-(16)-b-D-galactopyranoside (6), kaempferol-3-O-a-L-rhamnopyranosyl(12)-O-[a-L-rhamnopyranosyl (16)]-b-D-glucopyranoside (7), kaempferol-3-O-[6''-O-(E)-p-coumaroyl]-b-D-glucopyranoside (8), kaempferol-3-O-[6''-O-(E)-p-coumaroyl]-b-D-galactopyranoside (9), and amentoflavone (10). All the structures were confirmed by the interpretation of NMR (1D and 2D) and MS data, and comparison with the published values. Of the isolated compounds 1 - 10, compounds 8 and 10 displayed the inhibitory activity against NO production in LPS-induced Raw 264.7 cells with IC50 values, 3.56 and 15.73 mM, respectively.
Park, Ji-Won,Kwon, Ok-Kyoung,Oh, Sei-Ryang,Lee, Joongku,Eum, Sangmi,Nguon, Samnang,Choi, Sang Ho,Khiev, Piseth,Ahn, Kyung-Seop SPANDIDOS PUBLICATIONS 2017 MOLECULAR MEDICINE REPORTS Vol.16 No.6
<P>Dipterocarpus obtusifolius has been traditionally used as a herbal medicine and is considered to have anticancer properties. The biological activity of D. obtusifolius in inflammation and the underlying mechanisms of its activity remain to be elucidated. The present study investigated the effects of D. obtusifolius methanolic extract (DOME) on lipopolysaccharide (LPS)-stimulated inflammation in RAW264.7 cells. The effects of DOME on the production of nitric oxide, prostaglandin E-2 and pro-inflammatory cytokines were assessed by ELISA, western blot analysis and reverse transcription-quantitative polymerase chain reaction. It was demonstrated that expression of inducible nitric oxide synthase, cyclooxygenase-2, interleukin-1 beta and tumor necrosis factor-a was suppressed by DOME in LPS-stimulated cells. Furthermore, treatment with DOME suppressed phosphorylation of mitogen activated protein kinase (MAPK) molecules, including extracellular signal-regulated kinase, c-Jun N-terminal kinase and p38 MAPK. Translocation of the nuclear factor-kappa B p65 subunit into the nucleus was additionally inhibited by DOME. Phosphorylation of MAPK promoter activity was inhibited by treatment with DOME, PD98059, SB202190 and SP600125. These results demonstrated that DOME inhibits LPS-induced inflammatory responses. Therefore, DOME may be a potential therapeutic approach for the treatment of inflammatory diseases.</P>