http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Rehabilitation in Children With Sclerodermoid Chronic Graft-Versus-Host Disease: Case Series
Minji Jung,성인영,Eun Jae Ko 대한재활의학회 2019 Annals of Rehabilitation Medicine Vol.43 No.3
Joint contracture in chronic graft-versus-host disease (cGVHD) is refractory to treatment, and tends to deteriorate gradually over time. There is scant clinical research focusing on timing and intensity of rehabilitation on joint contractures in children with sclerodermoid cGVHD after hematopoietic stem cell transplantation. We retrospectively reviewed rehabilitative therapeutic effects in 6 children with sclerodermoid cGVHD, whose clinical records documented their condition, before and after rehabilitation therapies. Three children who started treatment within a mean of 2 months after the onset of joint symptoms, and who underwent home-based exercise twice daily for 30 minutes showed more prominent improvement in range of motion compared with the other 3 children, who started rehabilitation therapy later than 6 months after onset of joint symptoms, without regular home-based exercise.
Relationship Between Swallowing Function and Maximum Phonation Time in Patients With Parkinsonism
Ko, Eu Jeong,Chae, Minji,Cho, Sung-Rae Korean Academy of Rehabilitation Medicine 2018 Annals of Rehabilitation Medicine Vol.42 No.3
<P><B>Objective</B></P><P>To identify the relationship between maximum phonation time (MPT) and swallowing function, as well as the elements of swallowing, in order to provide a rationale for speech therapy in patients with Parkinsonism manifesting dysphagia.</P><P><B>Methods</B></P><P>Thirty patients with Parkinsonism who underwent speech evaluation and videofluoroscopic swallowing study (VFSS) were recruited. The MPT, the longest periods of sustained pronunciation of /aa/, was evaluated. The VFSS was evaluated using Penetration Aspiration Scale (PAS), National Institutes of Health-Swallowing Safety Scale (NIH-SSS), and Videofluoroscopic Dysphagia Scale (VDS). The relationship between dysphagia scales and MPT was analyzed using Pearson correlation. The difference in VDS variables between subgroups (Parkinson disease or Parkinsonian syndrome, independent or dependent ambulation, and normal or abnormal MPT) and the difference in MPT between subgroups based on the VDS variables were analyzed using the independent t-test.</P><P><B>Results</B></P><P>Bolus formation and laryngeal elevation functions were significantly higher in the normal MPT group compared with the impaired group. In the VDS variables, patients with intact bolus formation, oral transit time, pharyngeal swallow triggering, and laryngeal elevation showed significantly longer MPTs compared with the impaired groups. In addition, MPT was significantly correlated with the VDS and modestly correlated with the NIH-SSS, but not the PAS, suggesting that phonatory function is related to the oropharyngeal swallowing function, but not directly to the aspiration itself.</P><P><B>Conclusion</B></P><P>The correlation between MPT and several swallowing-related elements was identified, indicating an interactive correlation between swallowing and phonation. This result justifies voice therapy as a treatment for dysphagia in patients with Parkinsonism.</P>
Individualized Acupuncture for Symptom Relief in Functional Dyspepsia: A Randomized Controlled Trial
Ko, Seok-Jae,Kuo, Braden,Kim, Seul-Ki,Lee, Hyangsook,Kim, Jinsung,Han, Gajin,Kim, Juyeon,Kim, Song-Yi,Jang, Seungwon,Son, Jiyoung,Kim, Minji,Lee, Hyejung,Yeo, Inkwon,Joo, Kwang Ro,Park, Jae-Woo Mary Ann Liebert 2016 Journal of Alternative & Complementary Medicine Vol.22 No.12
Ko, Young-Rae,Hwang, Yoonkyu,Chae, Minji,Kim, Tae-Hyoung Elsevier 2017 ISA transactions Vol.70 No.-
<P><B>Abstract</B></P> <P>In this study, we present an identification-based direct construction of the inverse generalized Prandtl–Ishlinskii (P–I) model to facilitate inverse model-based feedforward compensation of asymmetric hysteresis nonlinearities. Compared with the derivation of the inverse model analytically from a generalized P–I model, this direct modeling approach has the following advantages. First, direct inverse model identification is formulated as a nonlinear optimization problem, which is not subject to the constraint condition on the generalized P–I model's threshold and density functions, where this is indispensable for the analytical model inversion procedure. Second, this approach may be a simple and attractive alternative when the identification precision of a generalized P–I model is limited by the constraint condition, which necessarily results in insufficient hysteresis compensation functionality for the analytically derived inverse model. Finally, direct inverse model identification can overcome the drawbacks of the analytical inversion method, including the accumulation of parameter estimation errors in an analytical inverse model because these parameters are computed from the generalized P–I model's parameters in a recursive manner. Our experimental results demonstrated that the implementation of open-loop control with the directly identified inverse generalized P–I model as a feedforward compensator achieved precise compensation for the asymmetric hysteresis nonlinearities of a piezoelectric stack actuator.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Drawbacks of the analytical inversion of a generalized P-I model are discussed. </LI> <LI> Identification-based direct construction of an inverse generalized P-I model is proposed. </LI> <LI> It facilitates the feedforward compensation of asymmetric hysteresis nonlinearities. </LI> <LI> Experiments validated the performance of our direct-identification-based scheme. </LI> </UL> </P>
Ko, Hyun Myung,Lee, Sung Hoon,Bang, Minji,Kim, Ki Chan,Jeon, Se Jin,Park, Yeong-Min,Han, Seol-Heui,Kim, Hahn Young,Lee, Jongmin,Shin, Chan Young Elsevier 2018 Biochemical and biophysical research communication Vol.495 No.1
<P><B>Abstract</B></P> <P>The high concentrations of nitric oxide (NO) produced by inducible nitric oxide synthase (iNOS) in activated glial cells in response to neuroinflammatory stimuli have neurotoxic effects on the brain. At basal levels, iNOS expression is low, and proinflammatory stimuli induce iNOS expression in astrocytes, microglia, and oligodendrocytes. Fyn, a non-receptor tyrosine kinase, regulates iNOS expression in several types of immune cells. However, its role in stimulated astrocytes is less clear. In this study, we investigated the role of Fyn in the regulation of lipopolysaccharide (LPS)-induced iNOS expression in astrocytes from mice and rats. Intracerebroventricular LPS injections in cortical regions enhanced iNOS mRNA and protein levels, which were increased in Fyn-deficient mice. Accordingly, LPS-induced nitrite production was enhanced in primary astrocytes cultured from Fyn-deficient mice or rats. Similar results were observed in cultured astrocytes after the siRNA-induced knockdown of Fyn expression. Finally, we observed increased LPS-induced extracellular signal-regulated protein kinase (ERK) activation in Fyn-deficient astrocytes. These results suggested that Fyn has a regulatory role in iNOS expression in astrocytes during neuroinflammatory responses.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Fyn regulates LPS-induced iNOS expression in the cortices. </LI> <LI> Fyn modulates iNOS expression and nitrite levels in LPS-stimulated astrocytes. </LI> <LI> Fyn regulates iNOS expression in LPS-stimulated astrocytes via ERK phosphorylation. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
경련성 질환을 가진 장애 아동에서 치아로 추정되는 이물질 흡인에 의한 폐렴
박민지(Minji Park),이고은(Ko-Eun Lee),이제호(Jae-Ho Lee) Asia association of Disability and Oral health 2018 International Journal of Disability and Oral Healt Vol.14 No.1
Aspiration of tooth can occur not only during dental treatment, but also due to factors like trauma or physiologic exfoliation of primary tooth. If this occurs, complications such as fever, cough, dyspnea, pain, and bronchitis can be appeared. 9 years-old girl with Lennox-Gastau syndrome visited the dental clinic for regular checkups. Calcified tooth-like material was observed in the chest PA x-ray, and maxillary left primary first molar was not observed in the patient’s oral cavity. She had a history of hospitalization for pneumonia two months ago. Because it was considered that the tooth was likely to be aspirated and caused pneumonia, the extraction of remaining primary teeth with mobility was performed. It is necessary to reduce the risk of aspiration in patient with disabilities by performing active treatment such as removal of primary tooth with mobility or ill-fitting restorations.