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      • 대구시 용도지역 변경과정에 관한 연구 : 도시계획 결정고시문을 중심으로

        공장표,임현철 嶺南大學校 環境問題硏究所 1997 環境硏究 Vol.16 No.2

        요 약 문 오늘날 대구라는 도시는 행정구역의 개편과 더불어 광역시로 변모함에 따라 새로운 종합적인 도시계획의 검토가 요구되는 시점에 놓여있다. 그래서 본 연구에서는 대구 최초의 현대적개념의 도시계획인 1937년의 대구부시가지계획에서부터 1994년 9월까지 결정고시되었 던 각종 도시계획을 대상으로 용도지역 변경과정상의 특성을 연구하고자 하였다.연구결과를 간략히 요약하면 다음과 같다. 1. 시기별로 보면 1970년대 중반까지가 대구 도시계획에 있어서는 도시계획법의 운용과 용 도지역의 면적변경 과정면에서 어느 정도 체계를 잡아가던 시기로 볼 수 있다. 2. 용도지역의 면적증감은 개별 도시계획의 종합적인 형태인 도시계획재정비시에 큰 변화를 보이고 있는데, 이를 제외하고 보면 주거 ·상업 ·공업지역의 증가는 관련 개별 도시계획 사업에 의한 것이,주거 ·공업지역의 감소는 일반 용도지역의 변경 및 기타요인 특히,개발제 한구역 지정(1972)과 시내일부지역의 녹지지역지정(1975)에 의한 영향이 컸으며,상업지역의 감소는 주거지와 공업지를 개발하기 위한 도시계획사업에 의한 면적감소가 크게 나타났다. 그리고 녹지지역은 타 용도지역의 개발을 위한 유보지의 성격을 지녀왔음을 볼 수 있었다. 3.도시계획의 운용면에서 초기에는 법적 용어를 벗어난 애매한 용어를 사용하여 고시하는 예가 많았고,용도지역이 세분화되어 있음에도 불구하고 곧바로 용도지역을 지정하는 경우가 드물어 탄력적으로 운용되지는 않은 듯 하다. AbstractAs a metropolitan area, Taegu city requires to establish a new urban planning. The purpose of this research is to define characteristics of the zoning change process in Taegu city from 1937 to 1994.The result of this study is summarised as follows ; 1. Until the middle of 1970's, Taegu city tried to settle the systematical urban planning through the Urban Planning Act legislation and its revision with the change of square measure of zoning. 2. The change of square measure is remarkable in the general urban planning and each urban development project basis. Green track of land has been kept as reserved a piece of properties for suitable future use. 3. In the early phase of urban planning history, Taegu city used vague legal terms and stayed as positivelessness to designate the subdivision zoning.

      • KCI등재

        Quantitative Trait Locus Mapping and Candidate Gene Analysis for Plant Architecture Traits Using Whole Genome Re-Sequencing in Rice

        Lim, Jung-Hyun,Yang, Hyun-Jung,Jung, Ki-Hong,Yoo, Soo-Cheul,Paek, Nam-Chon Korean Society for Molecular and Cellular Biology 2014 Molecules and cells Vol.37 No.2

        Plant breeders have focused on improving plant architecture as an effective means to increase crop yield. Here, we identify the main-effect quantitative trait loci (QTLs) for plant shape-related traits in rice (Oryza sativa) and find candidate genes by applying whole genome re-sequencing of two parental cultivars using next-generation sequencing. To identify QTLs influencing plant shape, we analyzed six traits: plant height, tiller number, panicle diameter, panicle length, flag leaf length, and flag leaf width. We performed QTL analysis with 178 $F_7$ recombinant inbred lines (RILs) from a cross of japonica rice line 'SNU-SG1' and indica rice line 'Milyang23'. Using 131 molecular markers, including 28 insertion/deletion markers, we identified 11 main- and 16 minor-effect QTLs for the six traits with a threshold LOD value > 2.8. Our sequence analysis identified fifty-four candidate genes for the main-effect QTLs. By further comparison of coding sequences and meta-expression profiles between japonica and indica rice varieties, we finally chose 15 strong candidate genes for the 11 main-effect QTLs. Our study shows that the whole-genome sequence data substantially enhanced the efficiency of polymorphic marker development for QTL fine-mapping and the identification of possible candidate genes. This yields useful genetic resources for breeding high-yielding rice cultivars with improved plant architecture.

      • Graphene oxide induces apoptotic cell death in endothelial cells by activating autophagy via calcium-dependent phosphorylation of c-Jun N-terminal kinases

        Lim, Mi-Hee,Jeung, In Cheul,Jeong, Jinyoung,Yoon, Sung-Jin,Lee, Sang-Hyun,Park, Jongjin,Kang, Yu-Seon,Lee, Hansu,Park, Young-Jun,Lee, Hee Gu,Lee, Seon-Jin,Han, Baek Soo,Song, Nam Woong,Lee, Sang Chul Elsevier 2016 Acta Biomaterialia: structure-property-function re Vol.46 No.-

        <P><B>Abstract</B></P> <P>Despite the rapid expansion of the biomedical applications of graphene oxide (GO), safety issues related to GO, particularly with regard to its effects on vascular endothelial cells (ECs), have been poorly evaluated. To explore possible GO-mediated vasculature cytotoxicity and determine lateral GO size relevance, we constructed four types of GO: micrometer-sized GO (MGO; 1089.9±135.3nm), submicrometer-sized GO (SGO; 390.2±51.4nm), nanometer-sized GO (NGO; 65.5±16.3nm), and graphene quantum dots (GQDs). All types but GQD showed a significant decrease in cellular viability in a dose-dependent manner. Notably, SGO or NGO, but not MGO, potently induced apoptosis while causing no detectable necrosis. Subsequently, SGO or NGO markedly induced autophagy through a process dependent on the c-Jun N-terminal kinase (JNK)-mediated phosphorylation of B-cell lymphoma 2 (Bcl-2), leading to the dissociation of Beclin-1 from the Beclin-1–Bcl-2 complex. Autophagy suppression attenuated the SGO- or NGO-induced apoptotic cell death of ECs, suggesting that SGO- or NGO-induced cytotoxicity is associated with autophagy. Moreover, SGO or NGO significantly induced increased intracellular calcium ion (Ca<SUP>2+</SUP>) levels. Intracellular Ca<SUP>2+</SUP> chelation with BAPTA-AM significantly attenuated microtubule-associated protein 1A/1B-light chain 3-II accumulation and JNK phosphorylation, resulting in reduced autophagy. Furthermore, we found that SGO or NGO induced Ca<SUP>2+</SUP> release from the endoplasmic reticulum through the PLC β3/IP<SUB>3</SUB>/IP<SUB>3</SUB>R signaling axis. These results elucidate the mechanism underlying the size-dependent cytotoxicity of GOs in the vasculature and may facilitate the development of a safer biomedical application of GOs.</P> <P><B>Statement of Significance</B></P> <P>Graphene oxide (GO) have received considerable attention with respect to their utilization in biomedical applications. However, GO-related safety issues concerning human vasculature are very limited. In this manuscript, we report for the first time the differential size-related biological effects of GOs on endothelial cells (ECs). Notably, Subnanometer- and nanometersized GOs induce apoptotic death in ECs via autophagy activation. We propose a molecular mechanism for the GO-induced autophagic cell death through the PLCβ3/IP3/Ca<SUP>2+</SUP>/JNK signaling axis. Our findings could be provide a better understanding of the GO sizedependent cytotoxicity in vasculature and facilitate the future development of safer biomedical applications of GOs.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

      • Unique photoemission from single-layer graphene on a SiO<sub>2</sub> layer by a substrate charging effect

        Lim, Hyunseob,Song, Hyun Jae,Son, Minhyeok,Baik, Jae Yoon,Shin, Hyun-Joon,Choi, Hee Cheul Royal Society of Chemistry 2011 Chemical communications Vol.47 No.30

        <P>Single-layer graphene (SLG) shows an anomalously large surface charging effect during scanning photoelectron microscopy (SPEM), which is distinguished from bi-layer graphene (BLG). The different behaviour is believed due to a different screening effect for SLG and BLG.</P> <P>Graphic Abstract</P><P>Unique photoemission properties from single-layer graphene during scanning photoelectron microscopy were investigated. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c1cc12953h'> </P>

      • KCI등재

        Economic evaluation of acupuncture as an adjunctive treatment with usual care for mild-to-moderate knee osteoarthritis: A Markov model-based analysis

        Hyun Eunhye,Shin Byung-Cheul,Kim Namkwen,Lim Byungmook 한국한의학연구원 2023 Integrative Medicine Research Vol.12 No.3

        Background Collaborative care (CC), in which acupuncture is combined with usual care (UC), improves clinical outcomes and increases costs in knee osteoarthritis (KOA). We evaluated the economic feasibility of CC for Korean female patients with mild-to-moderate KOA by using a cost-effectiveness approach. Methods Two alternatives for KOA (1. UC as a comparator; and 2. CC as an intervention) were defined based on clinical guidelines, official Korean statistics, and expert validation. Each alternative was simulated in a Markov model every 6 months for 10 years. Estimates of costs, utilities, and transition probabilities were obtained from official statistics and previous studies. The effectiveness of CC was synthesized from randomized controlled trials. A base-case analysis of a limited societal perspective, univariate sensitivity analysis, and probability sensitivity analysis were performed. An annual discount rate of 4.5% and threshold of 20,000 United States dollar per Quality-adjusted life year (USD/QALY) were applied. Results Every incremental cost-effectiveness ratio (ICER) of CC calculated from the analyses was sub-threshold. In the base-case analysis, with a limited societal perspective, the ICER was 11,085 USD/QALY. The ICERs from the univariate sensitivity analyses were -2,577–16,748 USD/QALY. The average ICER in the probability sensitivity analysis was 12,412 USD/QALY. When the threshold surpassed 8,000 USD/QALY, the cost-effectiveness of CC exceeded 50%. The probability was 70.27% when the threshold was 20,000 USD/QALY. Conclusions CC for Korean female patients with mild-to-moderate KOA was generally cost-effective. Considering the limitations of the evidence, we propose a re-evaluation using further clinical studies in the future.

      • KCI등재

        넷-제로에너지주택의 공기열원 히트펌프시스템 동적거동 및 에너지성능 분석

        임희원(Lim Hee Won),김지현(Kim Ji Hyun),김일권(Kim Il Kwon),신우철(Shin U Cheul) 한국태양에너지학회 2022 한국태양에너지학회 논문집 Vol.42 No.6

        Air-source heat pumps (ASHPs) have somewhat lower operating performance than groundsource heat pumps (GSHPs), but they have been reported to have low initial investment costs and a great energy-cost-saving effect due to the implementation of net-zero-energy houses. In this study, we analyzed the dynamic behavior and energy performance of equivalent ASHPs in existing low-energy houses installed with GSHPs of 9 kW using TRNSYS dynamic simulation. The house with a total floor area of 194 ㎡ was an all-electric house and domestic hot water, space heating, and cooling energy were supplied by the ASHP. To summarize the main results, first, the annual space heating and cooling energy supply of the ASHPs was 7,698 kWh and 2,226 kWh, respectively, and the annual heating COP and cooling EER were 3.4 and 3.1, respectively. Second, the total annual power consumption of the proposed model with ASHPs was 8,218 kWh and the annual power generation of the 6 kWp PV system was 8,682 kWh, which generated a surplus of 464 kWh, achieving net-zero energy. Third, the total annual electricity charge was 249,000 generated by ASHPs (proposal model) connected to the “residential service” grid of KEPCO, which was reduced by approximately 66% compared to the 736,000 generated by the GSHPs (existing model) linked to a “general service” grid.

      • KCI등재

        고온 지중 계간축열시스템을 갖는 온실의 태양열 난방시스템 장기 열성능평가

        임희원(Lim Hee-Won),이현승(Lee Hyun-Seung),이왕제(Lee Wang-Je),신우철(Shin U-Cheul) 한국태양에너지학회 2021 한국태양에너지학회 논문집 Vol.41 No.6

        In this study, we analyzed the long-term feasibility of a solar heating system for a citrus greenhouse to address the financial difficulties facing farms and to reduce greenhouse gas emissions. The solar heating system consisted of an auxiliary boiler, a solar storage tank with a capacity of 100 ㎥ and a cylindrical borehole thermal energy system (BTES) with a storage volume of 2,905 ㎥. We installed an evacuated tube collector and flat-plate collector (both with a capacity of 302 ㎡) to measure and compare each solar fraction and thermal storage efficiency. TRNSYS 18 was used as the simulation tool. The annual solar fraction was found to be 83.2%, and the efficiency of thermal storage was 35.7%. In this case, the efficiency of evacuated tube collector and flat-plate collector was 68.7% and 33.2% respectively. This shows that the evacuated tube collector, operating at a relatively high temperature, was more efficient than the flat-plate collector. Despite the high solar fraction, the maximum operating temperature of the solar storage tank was 90° or less, indicating that the tank was less likely to fail due to overheating.

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