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Exon 양편 intron 을 공유하는 T cell recepror 유전자
김인수,손우익,이수만,최은애,한성구,나정숙,Mak, T . W .,박덕훈,홍수형,정은영 경북대학교 유전공학연구소 1987 遺傳工學硏究所報 Vol.2 No.1
The germline C-region genes encoding the murine T cell receptor β chain have been isolated, and the exon/intron sequence of the Cβ1 gene was determined. Analysis of the nucleotide and deduced amino acid sequences reveals that the Cβ1 gene is divided into four exons. Unlike the human Cα chain genes, an Alu element has not been found. Comparison of the Cβ1 gene with other receptor genes reveals that the α, βand γ chain genes share intron sequences flanking each axon of the respective genes.
( Whee Moon Cho ),( Seung Woo Nam ),( Jeong Ho Jang ),( Eunk Yung Lee ),( Eun Ah Lee ),( Young Sook Son ) 한국조직공학과 재생의학회 2010 조직공학과 재생의학 Vol.7 No.3
Current understanding provides that almost every tissue include stem cell niche, which contain stem cells. Although several lines of skeletal stem cells were found and reported so far, it was not possible to compare their regeneration potentials because these were examined in different systems. To utilize stem cells for tissue engineering purpose, it is essential to understand subtle differences and differentiation potentials between stem/progenitor cells of different tissues and compare them under the identical system. In this study, several lines of stem cells were isolated from bone marrow, adipose tissue, xiphisternum cartilage, tendon, and ligament and named as BMSCs, ADSCs, XDSCs, TDSCs, and LDSCs, respectively. Those cells of different origin, after in vitro expansion, were subjected to assess their differentiation potentials under identical condition and found to have difference in their in vitro differentiation potentials. Although all tested stem cells exhibited differentiation capacity to three lines of skeletal tissues including adipose cells, cartilage, and bone, there were subtle differences in their regeneration capacity. Interestingly, all the cells except BMSCs failed to show positive staining in in vitro osteogenic differentiation assay. XDSCs showed exceptionally superior chondrogenic differentiation at early stage of in vivo incubation suggesting a strong potential of XDSCs for cartilage repair.