A case of Stevens-Johnson syndrome with parotitis

( Eun Phil Heo ),( Chi Yeon Kim ),( Tae Jin Yoon ),( Tae Heung Kim ) 대한피부과학회 2000 초록집 Vol.38 No.10

모누두 종양 2 예

허은필(Eun Phil Heo),오지원(Chee Won Oh) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.6

Tumor of the follicular infundibulum(TFI) is rare benign adnexal tumor origination, from the infundibular portion of hair follicle. Majority of the lesions have been solitary and not recognized clinically before biopsy. TFI can be classified as follows according to the clinical presentation of the tumor (1) solitary tumor, (2) eruptive tumors, (3) TFT associated with other lesions of Cowden`s disease, (4) TFT arising in nevus sebaceus, and (5) TFT-like changes in various tumors. We present clinicopathologic features of 2 casts of TFT. One was solitary form and the other was associated with nevus sebacens.

피하 T - 세포 림프종 1 예

허은필(Eun Phil Heo),이원섭(Won Sup Lee),오지원(Chee Won Oh) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.5

Subcutancous panniculitie. T-cell lymphoma(SPTCL) is a rare subtype of peripheral T-call lymphoma that clinically and histologically mimies benign panniculids. It represents subeutaneous nodules prdominantly on extremities and turck and himophagoeytic syndromc almost leading to death. Recent reports suggest that cytophagic histocyde pammieulitis(CHP) and SPTCL may span a clinieopathologic spectrum in which there is a natural disease progression from CHP to SPTCL. We reprot a 41-year-old Korean man who prescnted with recurrent tender crythematous subeutancous mokules on the buttock and extremites for 13 years history. There was no hipatosplenomegaly or lymphadenopathy. Laboratory data revealed mild ancmia, lcukopinia, and clevated alanine transterase. Epstein-Barr virus(EBV) scrlolgical values evidenced chronic active infection. His skin biopsy spceimen showed lobular pammiculitis with atypical lymphohistiocytic inflammatory infiloates. The inflammatory infilltrates expressed CK45RO, CD3, CD4, CD8, and CD68, But CD20 and CD56 were negative. In situ hybridizstion studies for the EBV ginome showed megative finding. This case presints SPTCL that had eluded diagnosis for a long time. It also suggests the improtance of comtinued follow-up with repeated biopsy, in case of long course of recurrent tender crythematous nokules and histological lobular lymphocytic pammiculitis.

옴 환자의 임상적 양상에 대한 연구

허은필 ( Eun Phil Heo ),민준홍 ( Joon Hong Min ),최종원 ( Chong Won Choi ),이가영 ( Ga Young Lee ),박수홍 ( Soo Hong Park ),김원석 ( Won Serk Kim ),김계정 ( Kea Jeung Kim ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.10

Background: Scabies is an ectoparasite caused by the mite Sarcoptesscabiei var. hominis, an obligate human parasite. Although the incidence of scabies is decreased nowadays, it is not rare and it is difficult to diagnose without experience. Objective: We conducted this study to evaluate clinical aspects of patients diagnosed with scabies in the last 4 years. Methods: We evaluated 56 patients who were diagnosed with scabies with a skin biopsy or with the mineral oil test. Medical records and telephone-interviews were used for more information. Results: There were 56 scabies patients, 28 males and 28 females. The mean age of the patients was 54 (male; 44.4/ female; 62.9) and 39.3% of patients were over 65 years. The most common affected site was the groin; common cutaneous lesions were pruritic papules and burrow. There was no seasonal variation in occurrence. The majority of suspected routes of infection were unknown but, nosocomial infection and communal living were also major causes. On average, 102 days were required to confirm scabies, which suggests the difficulty in early diagnosis of scabies. Conclusion: We suggest that dermatologists should consider scabies infection in patients who show pruritis that does not improve with ordinary treatment. (Korean J Dermatol 2011;49(10):882∼886)

하구순의 피부 병변에 대한 임상 연구

허은필 ( Eun Phil Heo ),김태흥 ( Tae Heung Kim ) 대한피부과학회 2002 大韓皮膚科學會誌 Vol.40 No.4

N/A Background : Lower lip skin disease is a fail y common disease in dermatology, but most dermatologist: are not familiar with clinical manifestations of lower lip skin diseases manifestating as cheilitis. Objective : We evaluated clinico-pathologic findings of lower lip skin diseases to suggest epideniolagical guideline of lower lip skin diseases. Methods : The retrospective clinical study was performed by r clinical photographs, pathologic slides, and the charts of 55 patients who had received skin biopsy for lower lip skin diseases from 1996 to 2000. Results : The results were as follows. Most of patients were older than 40 and men were commonly affected(M; F=3.2). About 58% of lower lip skin diseases were associated with ultraviolet(UV) radiation : 49% actinic cheilitis, 9.1% squamous cell carcintoma. Conclusion : This result suggests that UV played important roles in lower lip skin diseases, and education on photoprotection would be necessary to prevent squamous cell carcinoma.

Acitretin 치료로 호전된 비호지킨 림프종과 병발한 사마귀양 표피이형성증 1 예

허은필(Eun Phil Heo),엄성희(Sung Hee Um),오지원(Chee Won Oh) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.8

Epidermodysplasia verruciformis(EV) is a rare disease characterized by a unique susceptibility to widespread infection with human papilloma virus. It induces flat papular skin lesions, characterized by large vacuolated cells in the upper epithelial layers. We report a patient of EV in association with non-Hodgkins lymphoma(NHL) improved with systemic acitretin treatment. A 69-year-old man presented multiple red flat-topped papules and plaques on his face and upper extremities for 12 years. Past various therapeutic modalities including DPCP sensitization were entirely ineffective. Several years ago, NHL of cervical lymph node was diagnosed. With the treatments with chemotherapy and radiotherapy, he is now in remission state. His skin biopsy specimen showed extensive vacuolation of upper malpighian layer. Bleomycin IL trial showed no response. Only 1 week after oral acitretin administration, his lesions began to exfoliate and became much flatter. Acitretin was effective but not suitable for maintenance therapy.

적혈구 형광현미경검사로 진단한 적혈구 조혈성 프로토포르피린증

허은필(Eun Phil Heo),이원섭(Won Sup Lee),윤태진(Tae Jin Yoon),김태흥(Tae Heung Kim),김성언(Seong Eon Kim) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.1

Erythropoietic protoporphyria (EPP), caused by decreased activity of the enzyme ferrochelatase, is characterized clinically by burning photosensitivity beginning from childhood, and chemically by excessive amounts of red blood cell protoporphyrins. 1-10% of EPP patients develop potentially fatal protoporphyric hepatic failure. The diagnosis of EPP had been missed in many cases when traditional solvent extraction qualitative screening test was used for blood porphyrins, and use of fluorescence microscopy improved this problem. We report a case of EPP screened by fluorescence microscopy of erythrocytes in a 50-year-old man complaining of photosensitivity. We recommend fluorescence microscopy could be the screening test of choice for the detection of increased red blood cell porphyrins. (Korean J Dermatol 2002;40(1):63~67)

Aggressive Digital Papillary Adenoma 1 예

허은필(Eun Phil Heo),김지연(Chi Yeon Kim),오지원(Chee Won Oh) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.7

Aggressive digital papillary adenoma is a rare neoplasm of eccrine sweat gland origin. We report a case of aggressive digital papillary adenoma with literature reviews. Pathogenesis of this tumor is unclear but, according to his past history, possible induction by defoliants could not be ruled out. Several immunohistochemical studies were done to confirm tumoral origin and to evaluate histological potential of malignancy.

P058 A clinical study of cutaneous squamous cell carcinoma and their metastasis

( Sung Eun Song ),( Seung Gi Hong ),( Seung Woo Lee ),( Ki Woong Ro ),( Eun Phil Heo ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

<div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div> Background: The rate of metastasis in cutaneous squamous cell carcinoma has been estimated to range from 2% to 5%. Despite its low distant metastatic potential, the presence of distant metastasis is associated with a dismal prognosis. Objectives: In this study we investigated the recent trend of the cutansous squamous cell carcinoma metastasis in clinical and histopathological aspects. Methods: Two-hundreds two cases of SCC who had visited the Samsung Changwon Hospital during the last 10 years(between 2006.1.1 and 2015.12.31) were reviewed retrospectively. Results: The possible etiologic factor were Bowen``s disease (24 cases), actinic keratosis (15 cases), burn scar (3 cases), chronic inflammatory skin disorders such as anal fistula, chronic eczema (3 cases), arsenical keratosis, previous radiotherapy, operative scar and immune suppression (1 case each). Most commonly involved sites were the head and neck (157 cases), upper extremities (21 cases), lower extremities (11 cases), trunk (6 cases), perineum (5 cases) in decreasing order. In histopathologic aspects, poorly differentiated histological characteristics and invasion beyond subcutaneous tissue have the potency of metastasis. Regional lymph nodes were the mainly affected sites of metastasis(4 cases) of primary cutaneous SCC. Conclusion: Herein, we suggest a close follow-up plan such as every 3 months and a lymph node ultrasound in high risk group of SCC metastasis.

[P223] A case of Hay-Wells syndrome

( Sung Eun Song ),( Seung Gi Hong ),( Sun Young Jo ),( Ki Woong Ro ),( Eun Phil Heo ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

Hay-Wells syndrome, also known as Ankyloblepharon-Ectodermal dysplasia-Cleft lip/palate (AEC) syndrome, is a rare form of ectodermal dysplasia. It was first described by Hay and Wells in 1976. It is an autosomal dominant disorder caused by mutations in the gene encoding the transcription factor p63 (TP63). This disorder is characterized by ankyloblepharon, cleft lip/palate, and congenital ectodermal dysplasia (alopecia, scalp infections, dystrophic nails, hypodontia). 1-day-old female baby referred to inpatient dermatologic consultation with diffuse erythematous erosive patches on whole body. She had congenital anomalies includingankyloblepharon and cleft palate. She also had nail dystrophy on all fingernails and toenails. These clinical findings are compatible with Hay-Wells syndrome. She was treated by normal saline cleansing, emollients, and form dressing. Surgical corrections are scheduled for ankyloblepharon and cleft palate. Herein, we report a rare case of ectodermal dysplasia, Hay-Wells syndrome.