2-(3-Fluoro-4-methylsulfonylaminophenyl)propanamides as Potent Transient Receptor Potential Vanilloid 1 (TRPV1) Antagonists: Structure–Activity Relationships of 2-Amino Derivatives in the <i>N</i>-(6-Trifluoromethylpyridin-3-ylmethyl) C-Region

Kim, Myeong Seop,Ryu, HyungChul,Kang, Dong Wook,Cho, Seong-Hee,Seo, Sejin,Park, Young Soo,Kim, Mi-Yeon,Kwak, Eun Joo,Kim, Yong Soo,Bhondwe, Rahul S.,Kim, Ho Shin,Park, Seul-gi,Son, Karam,Choi, Sun,DeA American Chemical Society 2012 Journal of medicinal chemistry Vol.55 No.19

<P>A series of <I>N</I>-(2-amino-6-trifluoromethylpyridin-3-ylmethyl)-2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides were designed combining previously identified pharmacophoric elements and evaluated as hTRPV1 antagonists. The SAR analysis indicated that specific hydrophobic interactions of the 2-amino substituents in the C-region of the ligand were critical for high hTRPV1 binding potency. In particular, compound <B>49</B><I><B>S</B></I> was an excellent TRPV1 antagonist (<I>K</I><SUB>i(CAP)</SUB> = 0.2 nM; IC<SUB>50(pH)</SUB> = 6.3 nM) and was thus approximately 100- and 20-fold more potent, respectively, than the parent compounds <B>2</B> and <B>3</B> for capsaicin antagonism. Furthermore, it demonstrated strong analgesic activity in the rat neuropathic model superior to <B>2</B> with almost no side effects. Compound <B>49</B><I><B>S</B></I> antagonized capsaicin induced hypothermia in mice but showed TRPV1-related hyperthermia. The basis for the high potency of <B>49</B><I><B>S</B></I> compared to <B>2</B> is suggested by docking analysis with our hTRPV1 homology model in which the 4-methylpiperidinyl group in the C-region of <B>49</B><I><B>S</B></I> made additional hydrophobic interactions with the hydrophobic region.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jmcmar/2012/jmcmar.2012.55.issue-19/jm300780p/production/images/medium/jm-2012-00780p_0014.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jm300780p'>ACS Electronic Supporting Info</A></P>

Clinical characteristics of brain metastasis form ovarian cancer: A study of 51 cases

( Yeon Sik Na ),( Dea Yeon Kim ),( Yong Man Kim ),( Young Tak Kim ),( Joo Hyun Nam ),( Jong Hyeok Kim ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.98 No.-

The aim of this report is to describe the characteristics, pathologic features, treatments and survival of patients with brain metastasis from ovarian cancer at our single institution. Between January, 1989 and April, 2011, a total of 4625 women with ovarian cancer were evaluated at Asan Medical Center. A total of 71 patients were identified using the ICD-10 code for malignant neoplasm of ovary, cross-matched with the medical records for brain metastasis. Patients with other synchronous primary tumor were excluded. The clinical and pathologic characteristics, treatment and outcome of patients with brain metastases from epithelial ovarian carcinoma were analyzed using SPSS 12.0.using SPSS 12.0. The incidence of brain metastasis from ovarian cancer in our population was 1.1%(51/4625). The median survival from the diagnosis of brain metastases was 7 months (range: 0-72). Prior cancer relapse before the diagnosis of brain metastases, and multimodal treatment were related to the duration of survival. Although the prognosis for patients with brain metastases from epithelial ovarian carcinoma is generally poor, palliative therapy may offer symptomatic relief and improvement in the quality of life on ovarian cancer patients with brain metstasis.

유역모형을 이용한 산림지역 비점오염물질 유출특성 분석

김지연 ( Ji Yeon Kim ),김지현 ( Jee Hyun Kim ),정민경 ( Min Kyoung Jung ),지용대 ( Yong Dea Ji ),황재엽 ( Jae Yup Hwang ),박수영 ( Soo Young Park ),유재정 ( Jay Jung Yu ),김태승 ( Tae Seung Kim ) 한국물환경학회(구 한국수질보전학회) 2011 한국물환경학회·대한상하수도학회 공동 춘계학술발표회 Vol.2011 No.-

산림유역의 수문학적 해석을 위한 기저유출분석

김지연 ( Ji Yeon Kim ),지용대 ( Yong Dea Ji ),황승주 ( Seung Ju Hwang ),황재엽 ( Jae Yup Hwang ),박수영 ( Su Young Park ),김동호 ( Dong Ho Kim ),이영준 ( Young Joon Lee ) 한국물환경학회(구 한국수질보전학회) 2014 한국물환경학회·대한상하수도학회 공동 춘계학술발표회 Vol.2014 No.-

활엽수림 지역의 강우유출수 유출특성

지용대 ( Yong Dea Ji ),김지연 ( Ji Yeon Kim ),김지현 ( Jee Hyun Kim ),정민경 ( Min Kyoung Jung ),황재엽 ( Jae Yup Hwang ),박수영 ( Soo Young Park ),유재정 ( Jay Jung Yu ),김태승 ( Tae Seung Kim ) 한국물환경학회(구 한국수질보전학회) 2011 공동 추계학술발표회 Vol.2011 No.-

3.0T Brain MRI 검사 시 치아임플란트 시술 유무와 인체의 SAR, 체온 변화와의 상관관계에 관한 연구 : XFDTD 프로그램을 이용

Dea-yeon Choe,Dong-Hyun Kim 한국방사선학회 2017 한국방사선학회 논문지 Vol.11 No.3

At the Brain MRI examination, RF Pulse are irradiated on the human head in order to acquire MR images. At this time, a considerable part of the irradiated RF Pulse energy is absorbed in our body and the temperature of the human head will rise depending on the degree of exposure, so it will affect the human head. Even if the same RF Pulse energy is given, if the metal is inserted in the human head, the conductivity of the human head is greatly increased by the metal, so the SAR value increases and the temperature also rises. Therefore, we started this research with the question as to whether there is difference between the change in SAR value and temperature displayed on the head of the human according to use or not of the dental implant. Experiments were using the XFDTD program on a 128 MHz RF Pulse frequency by a 3.0 tesla MRI. We can see that both are increasing that the average value of SAR and temperature that absorbed by the human head model used the dental implant. In addition, the average maximum SAR value and the maximum temperature rise in the brain part are shown below the international safety standard value but the influence can not be ignored because of the result may change according to the increase in the number of dental implant. And as future tasks. we need to the simulation of temperature rise and SAR due to an increase in the number of implants and volumes of teeth, dental implant material.

Adiponectin-Activated AMPK Stimulates Dephosphorylation of AKT through Protein Phosphatase 2A Activation

Kim, Kun-yong,Baek, Ahmi,Hwang, Ji-Eun,Choi, Yeon A.,Jeong, Joon,Lee, Myeong-Sok,Cho, Dea Ho,Lim, Jong-Seok,Kim, Keun Il,Yang, Young American Association for Cancer Research 2009 Cancer Research Vol.69 No.9

<P>Low serum levels of adiponectin are a high risk factor for various types of cancer. Although adiponectin inhibits proliferation and metastasis of breast cancer cells, the underlying molecular mechanisms remain obscure. In this study, we show that adiponectin-activated AMPK reduces the invasiveness of MDA-MB-231 cells by stimulating dephosphorylation of AKT by increasing protein phosphatase 2A (PP2A) activity. Among the various regulatory B56 subunits, B56gamma was directly phosphorylated by AMPK at Ser(298) and Ser(336), leading to an increase of PP2A activity through dephosphorylation of PP2Ac at Tyr(307). We also show that both the blood levels of adiponectin and the tissue levels of PP2A activity were decreased in breast cancer patients and that the direct administration of adiponectin into tumor tissues stimulates PP2A activity. Taken together, these findings show that adiponectin, derived from adipocytes, negatively regulates the invasiveness of breast cancer cells by activating the tumor suppressor PP2A.</P>

Effects of Magnetic Resonance Imaging on the Human Body

Dea-yeon Choe(최대연),Dong-Hyun Kim(김동현) 한국방사선학회 2018 한국방사선학회 논문지 Vol.12 No.4

Brain MRI 검사에서는 영상을 얻기 위해 RF Pulse를 인체에 조사하게 되는데 이때 조사된 RF Pulse 에너지의 상당부분은 우리 몸에 그대로 흡수되게 되고 이로 인해 인체의 온도가 상승하게 되는데 노출정도에 따라 인체에 영향을 주게 된다. 그리고 같은 RF Pulse 에너지를 주었더라도 인체에 금속이 삽입되었다면 금속으로 인한 전자파 전도도가 증가하기 때문에 SAR가 증가하고 체온도 변화하게 된다. 이에 Brain MRI 검사 시 치아 임플란트의 재료에 따라 발생되는 두부 전체의 SAR와 온도의 변화를 비교 분석하고자 한다. 실험은 인체 두부모델에 1.5Tesla MRI장비에서 발생되는 64MHz RF Pulse 주파수, 3.0Tesla MRI장비에서 발생되는 128MHz RF Pulse 주파수를 조사한 뒤 치아 임플란트 재료를 Titanium과 Al₂O₃로 변화시킨 경우 두부 전체의 SAR와 온도 변화를 알아본다. 치아 임플란트 재료의 변화에서 Titanium을 사용하였을 때, 두부 전체의 SAR와 온도는 높게 나타났다. 하지만 Al₂O₃을 사용하였을 때, Titanium보다 두부 전체의 SAR와 온도는 낮게 나타났다. 치아 임플란트의 재료는 금속의 비중이 작은 경금속이면서 전기적 도체인 Titanium과 비교했을 때 전기전도도가 낮은 전기적 부도체인 Al₂O₃에서 두부 전체의 SAR와 온도는 낮게 나타났다. 치아 임플란트 재료가 Titanium 일 경우 SAR의 최대값은 제한치보다 월등히 높기 때문에 향후 Titanium의 치아 임플란트 재료를 삽입한 환자가 Brain MRI 검사를 할 경우 환자의 생물학적 영향과 관련된 연구가 필요할 것이다. 또한, 치아 임플란트 시술 시 Titanium보다는 Al₂O₃ 재질의 치아 임플란트를 사용하는 것이 Brain MRI 검사에서 인체 두부 전체의 SAR와 온도를 감소시키는 방안이라는 점을 발견할 수 있었다. In MRI examination, when irradiating the human body with RF Pulse to acquire images, the portion of the irradiated RF Pulse energy is absorded into the human body, and this will affect the temperature of the human body. If a metal is inserted into the human body even if the same RF Pulse energy is applied, the SAR value increases and the body temperature changes due to the increase in the electromagnetic wave conductivity of the metal. So we measure and compared with the change in the SAR and temperature in the implant material of the dental implant in Brain MRI examinations. Experiments were performed on a human head model using a 64MHz and 128 MHz RF Pulse frequency generated by a 3.0 Tesla MRI apparatus. And then changed material of dental implants to Titanium and Al₂O₃. Using the XFDTD program, the changes in SAR and body temperature around the head were examined. When with Titanium the SAR value and temperature of Brain increased, but with Al₂O₃ showed lower SAR and temperature as compared with Titanium. The dental implants were low in SAR and temperature of the head in Al₂O₃, which are electrical insulators with low electrical conductivity, compared to Titanium, which is an electrical conductor. It is necessary to study the biologic effect of patient with brain MRI when titanium dental implant material is inserted in the future. Because the maximum value of SAR is much higher than the limit when dental implant material is Titanium. In addition, it is necessary to use an implant of Al₂O₃ material to reduce the SAR value and temperature of the Brain in Brain MRI examination.

VCUG Studies on the Clinical Usefulness of Aids

최대연(Dea yeon Choe),김동현(Dong hyun Kim) 한국방사선학회 2015 한국방사선학회 논문지 Vol.9 No.7

VCUG 검사는 검사 중 배뇨를 해야 하기 때문에 하의를 벗은 상태에서 실시해야 해서 환자의 민망함과 불안감이 매우 큰 투시검사 중 하나이다. VCUG 검사는 배뇨 중 방광요관역류(VUR:Vesico Urthral Reflex)를 진단하기 위해서는 검사자와 의사가 배뇨의 전 과정을 지켜봐야 하고 환자가 직접 소변통을 들고 배뇨를 하면서 검사를 해야 하기 때문에 VCUG 검사 자체가 상당히 불편하다. 따라서 이러한 VCUG 검사는 환자의 인격을 고려한다면 향후 지양해야 할 검사이기도 하다. 그러나 이러한 VCUG 검사는 의료 비뇨기학적 진단에서 상당한 가치가 있고 아직까지 VCUG를 대체할 만한 검사법이 개발되지 않고 있다. 이에 VCUG 검사를 시행할 때 환자의 인격을 존중하고 환자의 민망함과 불안감을 감소시킬 수 있는 방안으로 VCUG 검사 팬티를 자체 제작하였고 VCUG 검사팬티를 사용한 실험군과 사용하지 않은 대조군들을 두 분류로 나누어 VCUG 검사 시간, 검사에 따른 환자가 받는 피폭 선량 그리고 환자 만족도를 비교 분석해 보았다. VCUG 검사 시간은 VCUG 팬티를 사용한 실험군이 27.8분, 대조군이 35.3분으로 실험군이 대조군에 비해 검사시간이 7.5분 단축되었다. 환자 피폭선량은 VCUG 검사 팬티를 사용한 실험군이 3411.9μGy㎡, 대조군이 4566.6μGy㎡으로 실험군이 피폭선량을 평균 1154.7μGy㎡를 감소시킬 수 있었다. 실험군과 대조군의 검사만족도 평가에서는 대조군 1.86에 비해 실험군 3.05로 실험군의 만족도가 매우 높았고 검사 중 수치심의 정도는 대조군 4.02에 비해 실험군 3.08로 수치심이 감소하는 것을 확인 할 수 있었다. 검사 중 불안감을 느끼는 정도는 대조군 3.45에 비해 실험군 2.51로 불안감을 적게 느끼는 것으로 나타났으며 배뇨가 잘 되는 정도는 대조군 1.90에 비해 실험군 2.84로 나타나 VCUG 검사 팬티를 사용함으로써 배뇨가 더 잘되는 것으로 나타났다. 따라서 VCUG 검사 팬티를 사용함으로써 검사시간과 환자의 피폭 선량이 단축되었으며 환자의 만족도 또한 향상되었다. VCUG(Voiding Cystourethrography) study is being performed to check urinary reflex symptom from bladder to ureter or kidney in the method of filling the bladder with radiation opaque contrast agent. However, VCUG study have been performed impersonally, patients have to be naked and open their legs and then void. This method is so impersonal that it is immediately needed to improve the way of testing and crete new aid. Therefore, this study through producing underwear for VCUG, analysis and compares the test time of VCUG, patient radiation dose and patient satisfaction. The target of this study was 79 Male and Female patients who visited genitourinary clinic of PNUYH for their VCUG tests AXIUM Iconos R200(Siemens Medical System : Germany) and self-produced plastic underwears made by vinyl and plasic molding machine were used. The 79 patient were divided into two groups : experiment of patient and comparison group of we patient (using aid) in order to compare, testing time, DAP (dose area product) and patient satisfaction. There was time reduction, from 35.3min of comparison group to 27.8min experimentation group by 7.5min decrease. And comparison group of 4566.6μGy㎡(DAP) decreased experimental group (using aid) of 3411.9μGy㎡ by 1154.7μ Gy㎡. In the case of patients satisfaction study, anxiety had a drop by 3.45 of comparison group to 2.51 experimentation group by 0.94 decrease. in experimental group. And shame had a drop by 4.02 of comparison group to 3.08 experimentation group by 0.94 increase. in experimental group. Difference of the smooth voiding had a drop by 1.90 of comparison group to 2.84 experimentation group by 0.94 increase. in experimental group. In addition satisfaction had a rise by 1.19 in experimental group. There were also other opinions of uncomfortableness on it and troublesome to wear. VCUG is one of the sensitive care required test. Therefore staff and the aid can give patients such comfortable and the aid can consentive on voiding. As a result test time and DAP can be reduced. It is needed to make testing at more comfortable for patients.

산사태로 인한 인명피해 대비 개인용 재난대피기구 개발 (Ⅰ) - 재하하중 및 재료시험 중심으로 -

김정면 ( Kim Jung Meyon ),황대원 ( Hwang Dea Won ),박성용 ( Park Sung Yong ),임창수 ( Lim Chang Su ),연규석 ( Yeon Kyu Seok ),김용성 ( Kim Yong Seong ) 한국농공학회 2016 한국농공학회논문집 Vol.58 No.5

The houses are formed in the lower part of the mountain slope face in most agricultural areas of Korea, and old residents accounting for a large portion of the agricultural populations cannot respond to the evacuation quickly when the landslide happens, and the possibility the life damage occurs is high. Therefore, it is urgent to arrange the measure on this. This study is intended to develop the personal disaster evacuation apparatus that can be installed in the house to minimize the life damage by the landslide and to develop the self-initiative evacuation apparatus. This study suggested the load applicable to the personal disaster evacuation apparatus by quantitatively analyzing the effect of the load of rockslides and avalanches caused by the landslide on the structure. Also, the material property of materials was calculated through the tension and bending intensity test after making the specimen of glass fiber reinforced plastic (GFRP) member. The load weight and material property drawn from this study can be used as the basic material for the stability analysis of the personal disaster evacuation apparatus.