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Chang, Boksoon,Han, Seo Goo,Kim, Wooyoul,Ko, Yousang,Song, Junwhi,Hong, Goohyeon,Eom, Jung Seop,Lee, Ji Hyun,Jhun, Byung Woo,Koh, Won-Jung The Korean Academy of Tuberculosis and Respiratory 2013 Tuberculosis and Respiratory Diseases Vol.75 No.1
Carbohydrate antigen 19-9 (CA 19-9) is a widely-used tumor marker in patients with pancreatic cancer. However, some patients with respiratory disease also exhibit elevated serum CA 19-9 levels. We report a case of normalization of elevated serum CA 19-9 levels after treatment of the nodular bronchiectatic form of Mycobacterium abscessus lung disease. A 40-year-old man visited our hospital because of chronic cough and sputum. A computed tomography scan revealed severe bronchiectasis in the right upper and right middle lobes. Nontuberculous mycobacteria were repeatedly isolated and identified as M. abscessus. The serum CA 19-9 level was elevated to 142.35 U/mL (normal range, <37 U/mL). Surgical resection was performed because of failure of sputum conversion after antibiotic treatment. The serum CA 19-9 level returned to the normal range after surgery. This case suggested that serum CA 19-9 levels could be elevated in patients with the nodular bronchiectatic form of M. abscessus lung disease.
Selective cytotoxic effect of non-thermal micro-DBD plasma
Kwon, Byung-Su,Choi, Eun Ha,Chang, Boksoon,Choi, Jeong-Hyun,Kim, Kyung Sook,Park, Hun-Kuk IOP 2016 Physical Biology Vol.13 No.5
<P>Non-thermal plasma has been extensively researched as a new cancer treatment technology. We investigated the selective cytotoxic effects of non-thermal micro-dielectric barrier discharge (micro-DBD) plasma in cervical cancer cells. Two human cervical cancer cell lines (HeLa and SiHa) and one human fibroblast (HFB) cell line were treated with micro-DBD plasma. All cells underwent apoptotic death induced by plasma in a dose-dependent manner. The plasma showed selective inhibition of cell proliferation in cervical cancer cells compared to HFBs. The selective effects of the plasma were also observed between the different cervical cancer cell lines. Plasma treatment significantly inhibited the proliferation of SiHa cells in comparison to HeLa cells. The changes in gene expression were significant in the cervical cancer cells in comparison to HFBs. Among the cancer cells, apoptosis-related genes were significantly enriched in SiHa cells. These changes were consistent with the differential cytotoxic effects observed in different cell lines.</P>
( Seon-hye Kim ),( Boksoon Chang ),( Jae Joon Hwang ),( In Kyoung Hwang ),( So Hee Park ),( Yee Hyung Kim ),( Cheon Woong Choi ),( Jee Hong Yoo ),( Hong Mo Kang ),( Myung Jae Park ) 대한결핵 및 호흡기학회 2015 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.120 No.-
Background: The uses of the tumor necrosis factor- α inhibitors increase the risk of developing TB. However, there is limited information about the clinical outcomes of active TB followed by TNF inhibitors and the appropriateness of TNF inhibitors readministration. Thus, we analyzed the clinical characteristics and treatment response of patients who developed TB after treating TNF inhibitors. Methods: We retrospectively reviewed all patients diagnosed with active TB after receiving TNF inhibitor from January 2001 through August 2015 at two academic hospitals in Korea. Outcomes were assessed via the medical records, bacteriological and radiologic findings and the response to anti-TB treatment. Results: 23 patients(1.4%) developed TB during a median of 316 days of TNF inhibitors. The LTBI screening was performed in all 23 patients and LTBI was diagnosed in 4 patients. In these patients, TB disease occurred even after LTBI treatment. Favorable course were showed in 21(91%) of 23 patients after administering first-line anti-TB medication, although 2 patients developed MDR TB. The 10 patients were retreated with TNF inhibitors: 6 patients were restarted during anti-TB treatment and the other 4 patients were reinitiated after completion of anti-TB medication. No TB recurrence was reported in the patients of resuming TNF inhibitors during a median follow-up of 26 months. Conclusions: We suggest that more specific protocol for diagnosis of LTBI and TB is required before and during TNF inhibitors. And recommencing TNF inhibitors may be considered and safe during the anti-TB medication
( Yousang Ko ),( Changhwan Kim ),( Boksoon Chang ),( Suh-young Lee ),( So Young Park ),( Eun-kyung Mo ),( Su Jin Hong ),( Myung Goo Lee ),( In Gyu Hyun ),( Yong Bum Park ) 대한결핵 및 호흡기학회 2017 Tuberculosis and Respiratory Diseases Vol.80 No.1
Background: Isolation of M. tuberculosis (MTB) is required in cases of Tuberculous pleural effusion (TBPE) for confirming diagnosis and successful therapy based on drug sensitivity test. Several studies have focused on predictors of MTB culture positivity in TBPE. However, the clinical role of loculated TBPE as a predictor of MTB cultivation from TBPE remains unclear. The aim of this study was to examine possible predictors including loculation of TBPE of MTB culture positivity in TBPE. Methods: We retrospectively examined associations between clinical, radiological, microbiological, and laboratory characteristics and positive MTB culture from TBPE to determine a potent predictor of culture positivity. Results: From January 2011 to August 2015, 232 patients with TBPE were identified. Of these, 219 were finally analyzed. Among them, 69 (31.5%) were culture positive for MTB in TBPE and 86 (39.3%) had loculated TBPE. In multivariate logistic regression analysis, the loculation of TBPE was independently associated with culture positivity for MTB in TBPE (adjusted odds ratio [OR], 40.062; 95% confidence interval [CI], 9.355-171.556; p<0.001). In contrast, the lymphocyte percentage of TBPE (adjusted OR, 0.934; 95% CI, 0.899-0.971; p=0.001) was inversely associated with culture positivity for MTB in TBPE. Conclusion: In clinical practice, identification of loculation in TBPE is easy, reliable to measure, not uncommon and may be helpful to predict the possibility of positive mycobacterial culture.
Ko, Yousang,Kim, Changhwan,Chang, Boksoon,Lee, Suh-Young,Park, So Young,Mo, Eun-Kyung,Hong, Su Jin,Lee, Myung Goo,Hyun, In Gyu,Park, Yong Bum The Korean Academy of Tuberculosis and Respiratory 2017 Tuberculosis and Respiratory Diseases Vol.80 No.1
Background: Isolation of M. tuberculosis (MTB) is required in cases of Tuberculous pleural effusion (TBPE) for confirming diagnosis and successful therapy based on drug sensitivity test. Several studies have focused on predictors of MTB culture positivity in TBPE. However, the clinical role of loculated TBPE as a predictor of MTB cultivation from TBPE remains unclear. The aim of this study was to examine possible predictors including loculation of TBPE of MTB culture positivity in TBPE. Methods: We retrospectively examined associations between clinical, radiological, microbiological, and laboratory characteristics and positive MTB culture from TBPE to determine a potent predictor of culture positivity. Results: From January 2011 to August 2015, 232 patients with TBPE were identified. Of these, 219 were finally analyzed. Among them, 69 (31.5%) were culture positive for MTB in TBPE and 86 (39.3%) had loculated TBPE. In multivariate logistic regression analysis, the loculation of TBPE was independently associated with culture positivity for MTB in TBPE (adjusted odds ratio [OR], 40.062; 95% confidence interval [CI], 9.355-171.556; p<0.001). In contrast, the lymphocyte percentage of TBPE (adjusted OR, 0.934; 95% CI, 0.899-0.971; p=0.001) was inversely associated with culture positivity for MTB in TBPE. Conclusion: In clinical practice, identification of loculation in TBPE is easy, reliable to measure, not uncommon and may be helpful to predict the possibility of positive mycobacterial culture.
Koh, Won-Jung,Chang, Boksoon,Jeong, Byeong-Ho,Jeon, Kyeongman,Kim, Su-Young,Lee, Nam Yong,Ki, Chang-Seok,Kwon, O Jung The Korean Academy of Tuberculosis and Respiratory 2013 Tuberculosis and Respiratory Diseases Vol.75 No.5
Background: The number of patients with pulmonary disease caused by nontuberculous mycobacteria (NTM) has been increasing worldwide. The aim of this study was to evaluate long-term trends in the NTM recovery rate from respiratory specimens over a 10-year period in a tertiary referral hospital in South Korea. Methods: We retrospectively reviewed the records of mycobacterial cultures of respiratory specimens at Samsung Medical Center from January 2001 to December 2011. Results: During the study period, 32,841 respiratory specimens from 10,563 patients were found to be culture-positive for mycobacteria. These included 12,619 (38%) Mycobacterium tuberculosis and 20,222 (62%) NTM isolates. The proportion of NTM among all positive mycobacterial cultures increased from 43% (548/1,283) in 2001 to 70% (3,341/4,800) in 2011 (p<0.001, test for trend). The recovery rate of NTM isolates from acid-fast bacilli smear-positive specimens increased from 9% (38/417) in 2001 to 64% (1,284/1,997) in 2011 (p<0.001, test for trend). The proportion of positive liquid cultures was higher for NTM than for M. tuberculosis (p<0.001). The most frequently isolated NTM were Mycobacterium avium-intracellulare complex (53%) and Mycobacterium abscessus-massiliense complex (25%). Conclusion: The recovery rate of NTM from respiratory specimens in South Korea has increased steadily.
( Dong Won Park ),( Jiin Choi ),( Seung Hyeun Lee ),( Boksoon Chang ),( Sung Jun Chung ),( Tai Sun Park ),( Hyun Lee ),( Ji-yong Moon ),( Sang-heon Kim ),( Tae-hyung Kim ),( Ho Joo Yoon ),( Jang Won S 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Background This present study aimed to investigate the prognostic significance of the Advanced Lung Cancer Inflammation Index (ALI) in peripheral blood of limited disease small-cell lung cancer (LD-SCLC) treated with chemoradiotherapy. Methods We included 87 consecutive LD-SCLC patients treated from 2005 to 2019 in South Korea. All patients were treated with definite chemoradiotherapy. Chemotherapy was etoposide combined with either carboplatin or cisplatin given mainly concomitantly with radiotherapy. ALI was calculated as the formula: body mass index x serum albumin/neutrophil-lymphocyte ratio (NLR). Survival curves were generated using the Kaplan-Meier method. Cox proportional hazards regression analyses were used to estimate hazard ratios (HRs) and determine risk factors predicting mortality. Results We classified 38 patients as high ALI (ALI ≥ 44.3) and 48 as low ALI group (ALI < 44.3). Compared with the low ALI group, patients in the high ALI group had a longer overall survival (OS) time. On multivariate analysis, performance status (P = 0.0222), prophylactic cranial irradiation (P = 0.0007), and ALI (P = 0.0044) were all independent prognostic factors for OS. Conclusions The Results of this study demonstrated that high ALI was significantly associated with better OS in LD-SCLC patients treated with chemoradiotherapy. For the initial evaluation of patients with LD-SCLC, pre-treatment ALI could predict the patients with good prognosis and be a useful prognostic marker in clinical practice.
( Jeong Mi Lee ),( Seung Hyeun Lee ),( Seung Sook Paik ),( Boksoon Chang ),( In Kyoung Hwang ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Purpose Although programmed death-ligand 1 (PD-L1) expression is accepted as a predictive biomarker in immunotherapy, its implications in lung cancer harboring driving mutations are still unclear. The objective of this study is to determine the association between PD-L1 expression and treatment outcome in epidermal growth factor receptor (EGFR)-mutated lung cancer treated with tyrosine kinase inhibitors (TKIs). Methods We retrospectively enrolled EGFR-mutant, advanced lung adenocarcinoma patients who received first-line EGFR-TKIs and evaluated the PD-L1 tumor proportion score (TPS) using the 22C3 pharmDx assay. We investigated the distribution of patients with different PD-L1 TPS values, followed by analysis of response rate (RR), survival rate, and incidence of secondary T790M mutation according to the PD-L1 TPS group. Results Among 131 patients analyzed, the proportion of patients with PD-L1 TPS ≥ 50%, 1%-49%, and < 1%, was 17.6%, 32.8%, and 49.6%, respectively. The RR was significantly lower in the group with PD-L1 TPS ≥ 50% than in the other groups (43.5% vs. 72.1% vs. 78.5%, all p = 0.001). In multivariate analysis, PD-L1 TPS ≥ 50% was independently associated with a significantly shorter PFS in overall population (hazard ratio [HR] = 2.64, p = 0.004, figure), and associated with shorter OS in patients with exon 19 deletion (HR = 2.55, p = 0.041) compared with PD-L1 TPS < 50%. In addition, the frequency of secondary T790M mutation after TKI failure was significantly lower in the group with PD-L1 TPS ≥ 50% than in the other groups (13.3% vs. 40.0% vs. 53.3%, all p = 0.001). PD-L1 TPS ≥ 50% was an independent predictor of a lower frequency of this mutation (HR = 0.63, p = 0.043). Conclusion High PD-L1 expression was associated with unfavorable clinical outcome, and less development of secondary T790M mutation, suggesting a distinct subgroup warranting active surveillance and tailored therapeutic approach.
A Case of Pleural Paragonimiasis Confused with Tuberculous Pleurisy
Song, Junwhi,Hong, Goohyeon,Song, Jae-Uk,Kim, Wooyoul,Han, Seo Goo,Ko, Yousang,Chang, Boksoon,Jeong, Byeong-Ho,Eom, Jung Seop,Lee, Ji Hyun,Jhun, Byung Woo,Jeon, Kyeongman,Kim, Hong Kwan,Koh, Won-Jung The Korean Academy of Tuberculosis and Respiratory 2014 Tuberculosis and Respiratory Diseases Vol.76 No.4
Here, we report a case of pleural paragonimiasis that was confused with tuberculous pleurisy. A 38-year-old man complained of a mild febrile sensation and pleuritic chest pain. Radiologic findings showed right pleural effusion with pleural thickening and subpleural consolidation. Adenosine deaminase (ADA) activity in the pleural effusion was elevated (85.3 IU/L), whereas other examinations for tuberculosis were negative. At this time, the patient started empirical anti-tuberculous treatment. Despite 2 months of treatment, the pleural effusion persisted, and video-assisted thoracoscopic surgery was performed. Finally, the patient was diagnosed with pleural paragonimiasis based on the pathologic findings of chronic granulomatous inflammation containing Paragonimus eggs. This case suggested that pleural paragonimiasis should be considered when pleural effusion and elevated ADA levels are observed.