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Alpha-Chymotrypsin이 白鼠各臟器 組織비반細胞에 미치는 影響에 關한 實驗的硏究
林大銑 中央醫學社 1941 中央醫學 Vol.10 No.6
Observation on the appearance of tissue mast cells in the skin tissue and various tissues in the trachea, esophagus and stomach were made after stimulating them physically with 22-gauge needle during three seconds upon the centro-lateral portion of the right thigh, similarly with 0.1 Ch. unit and 1.0 Ch. unit alpha-Chymotrypsin injections, proteolytic enzyme in the animal, using healthy albino-rats weighing 120-130 gm. The follow-studies were made after various intervals. The mast cell count was made covering 20 high power fields in each section and the findings in the different part were compared. The results of the study were summarized as follows. 1. The total number of mast cells appeared in each of the tissues, observed in the group stimulating with 22-gauge needle, shows a minimum value three hours after injection, and recovers respectively 8-12 hours normally. 2. In the groups stimulating with alpha-Chymotrypsin intra-musculary the total number of mast cells appeared in each of the tissues shows a minimum value one hour after injection and it takes about two days to recover their normal value. 3. Comparing 0.1 Ch. unit alpha-Chymotrypsin administered group with 1.0 Ch. unit administered group, the decreasing rate of tissue mast cells in each organism marked in latter group. 4. When stimulations were made on the right side skin with 22-gauge needle and alpha-Chymotrypsin, very resemble change was occurred histophathologically in the number of the mast cells of the left side skin notwithstanding the distance. 5. In the decreasing rate of its total mast cells, the skin is the highest among others, and the next are in the order of the trachea, stomach and esophagus. 6. In the morphology of the tissue mast cells after various stimulation the percentage of the normal mast cells decreased and that of the degranulation form of the tissue mast cells increased when the number of tissue mast cells decreased and thereafter, as the number of mast cells increased, the percentage of the normal form increased and that of the degranulation form decreased, thus' reaching the normal state. 7. The above results lead to a conclusion that the decrease in the total mast cells is of non-specific generalized , nature in the various organs of albino rat, stimulating with 22-gauge needle and alpha-Chymotrypsin.
林大銑,宋圭鉉,朴敬浩,朴暎緖,李玩永 中央醫學社 1963 中央醫學 Vol.5 No.4
A case of secondary aspergillosis of the left maxillary sinus following chronic sinusitis in a 42 year old male coal miner specialist is reported. His chief complaints were nasal obstruction and postnasal drip of several years duration. Roentgenogram revealed marked and moderate shadow in the left and right maxillary sinuses respectively. Significant operative findings included almost paper-thin bony walls of the left maxillary sinus, and small amount of yellow greenish purulent material was drained, followed by yellowish brown semisolid tissue on further curettage. The latter specimen was found to be essentially mass of fungi, showing numerous distinctly septate, branching hyphae on the Papanicolaou stain of the direct smears of the cut surface of the specimen, and Hematoxylin-Eosin and Periodic Acid Schiff stains of paraffin sections. Pertinent aspects of clinical and pathological differential diagnosis between aspergillosis - and mucormycosis, are described. Aspergillosis presents usually benign course, with insignificant chief complaints as our case, whereas mucormycosis is most frequently associated with uncontrollable diabetics, and run usually acutely fatal course. There are three main types of ucormycosis-cerebral, pulmonary and intestinal. The characteristic broad nonseptate branching hyphae of mucor, and marked affinity to the blood vessels,, penetrating the tough walls of arteries, with thromboses and infarction, readily differentiate aspergillosis from mucormycosis.