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황보태영 ( Taeyoung Hwangbo ),이인환 ( In Hwan Lee ),이승재 ( Seung Jae Lee ) 충북대학교 산업과학기술연구소 2011 산업과학기술연구 논문집 Vol.25 No.2
Recent experimental observations support the hypothesis that mechanical stimuli play a role in regulating specialized molecules expression in articular cartilage in vitro and in vivo. These specific molecules might be induced by the initiation of relative motion between the articular cartilage surfaces. Other studies have demonstrated that the continuous passive motion (CPM) bioreactor for whole joint can provides a platform for possible future in vitro studies and applications including possible interactions of biomechanical and biochemical signals. The objectives of this study were to develop the biomimetic bioreactor could be used to stimulate a whole joint during culture. This system consists of a joint culture chamber and a CPM-like stimulation device. This system could be used to investigate the effects of rehabilitative joint motion in dynamic culture..