수컷 생쥐 생식기관의 형태에 미치는 에스트로겐 수용체 알파의 선택적 촉진제의 농도별 영향

한지연,조영국,조현욱,Han, Ji-Yeon,Cho, Young-Kuk,Cho, Hyun-Wook 한국현미경학회 2011 Applied microscopy Vol.41 No.1

Known as a female hormone, estrogen, has an effect on the male reproductive organs. The estrogen has to combine with the estrogen receptor to communicate a signal. Propyl pyrazole triol (PPT) is an estrogen receptor alpha selective agonist with a 410-, or 1,000-fold relative binding affinity for estrogen receptor alpha versus estrogen receptor beta. In this study, adult male mice were treated weekly with subcutaneously injections of PPT (0.01 mg, 0.1 mg, 1mg and 4 mg) suspended in castor oil (as control) for 8 weeks and observed histologically changes in testis, efferent ductule and epididymis. In the high concentrations of PPT 4 mg treatment group, a remarkable reduction was observed in the weight of the body, testis and epididymis. Microscopic examination revealed a reduction in seminiferous tubular diameter of the testis, and epithelial cell height of the epididymis in treated group during the experiment. In addition, as the diameter of the efferent ductule increased gradually, the height of epithelial cells was decreased. PPT 4 mg treatment group caused inhibition of spermatogenesis due to atrophied germinal epithelium in the testis, and decrease of adipocyte size attached to the epididymis. Sperm was not observed in the caudal epididymis of PPT 4 mg treated group. In conclusion, the injection of high concentrations of PPT into adult male mice induced physiological changes, such as an inhibition of spermatogenesis, and also histological changes within the reproductive organs. 암컷호르몬으로 알려져 있는 에스트로겐이 실제로는 수컷 생식기관에도 영향을 미친다. 에스트로겐은 수용체와 결합하여 그 작용을 나타낸다. Propyl pyrazole triol (PPT)은 에스트로겐 수용체 베타에 비해 상대적으로 알파에 410배 혹은 1,000배 더 높은 선택적 친화성으로 결합하는 에스트로겐 수용체 알파 촉진제이다. 본 연구에서는 성체 수컷 생쥐를 대상으로 castor oil에 각각 0.01 mg, 0.1 mg, 1 mg, 4mg의 농도로 희석한 PPT를 1주에 1회씩 8주 동안 피하주사 하였다. 대조군은 castor oil을 주 1회씩 동일한 기간 동안 생쥐에 피하주사 하였다. 정소, 수출소관, 부정소의 조직학적 변화를 현미경으로 관찰하였다. PPT 4mg의 고농도 투여군에서는 체중, 정소, 부정소의 무게가 뚜렷하게 감소되었다. 실험기간 동안 PPT에 의해 세정관의 직경, 부정소의 상피세포 높이가 감소되었다. 부정소에 붙어 있던 지방세포의 크기는 PPT에 의해 줄어들었다. PPT 4 mg 투여군의 경우, 부정소의 꼬리 부위에 저장되는 정자가 관찰되지 않았다. 결론적으로 고농도의 PPT 투여로 인해 성체 수컷 생쥐의 정자형성 억제와 같은 생리학적 변화가 유발되었고 동시에 생식기관의 조직학적 변화도 유발되었다.

표준 중국어의 구어 명료도와 음소 대조 및 음향 자질의 발달적 상관관계

한지연,Han, Ji-Yeon 대한음성학회 2006 말소리 Vol.59 No.-

This study was designed to investigate the relationship between intelligibility and phonemic contrasts, and acoustic features in terms of speech development. A total of 212 Putonghua speaking children was participated in the experiment. There were phonemic contrasts significantly related with speech intelligibility: aspirated vs. fricative, retroflex vs. unretroflex, and front vs. back nasal vowel contrast. A regression analysis showed that 88% of the speech intelligibility could be predicted by these phonemic contrasts. Acoustic values were significantly related to the intelligibility of the Putonghua-speaking children's speech: voice onset time of unaspirated stops, and the duration of frication noise in fricatives.

하이브리드 대학도서관 환경에서의 도서관 이용자의 이용 의도에 관한 연구

한지연,문성빈,Han, Jiyeon,Moon, Sung-Been 한국정보관리학회 2020 정보관리학회지 Vol.37 No.3

본 연구는 대학의 교수와 학생 이용자가 전통적인 형태의 물리적 도서관과 온라인 정보이용 중심의 디지털 도서관이 혼합된 하이브리드 형태의 도서관 환경에서 대학도서관을 이용하고자 하는 행동 의도 즉, 도서관 이용 의도를 결정하는 요인들과 그 요인들 사이의 구조적 관계를 분석하고자 하였다. 대학의 주요 구성원 그룹이 가지고 있는 대학도서관에 대한 전반적인 인식을 조사하기 위하여 구조화된 설문지를 개발하여 자료를 수집하였고, 도서관 이용 의도에 영향을 미치는 요인들 간의 관계 분석을 위해 사회심리학에서 빈번히 활용되는 행동-태도 이론을 바탕으로 본 연구의 목적에 적합하다고 판단되는 계획행동이론(TPB)과 기술수용모형(TAM)을 기반으로 한 통합모형을 제안하여 분석을 실시하였다. 본 연구는 이용환경 변화에 따른 이용자의 도서관 이용에 대한 인식과 이용의도를 물리적 도서관과 디지털도서관으로 나누어 각각 확인하였고, 이를 바탕으로 향후 도서관의 미래 전략 및 운영 방안에 대해 논의해 보고자 하였다는데 그 의의가 있다고 할 수 있으며, 본 연구의 결과는 대학도서관으로 하여금 변화하는 환경에서 생존하고 균형적인 성장을 이루기 위해서는 인지, 주목, 그리고 협력을 바탕으로 한 효과적이며 효율적인 운영전략을 수립하여야 한다는 점을 주지하고 있다. This study investigates the factors affecting behavioral intention of professors and students at universities to use academic libraries in a hybrid library environment where a traditional physical library is combined with a digital library that is centered on online information use. The structural relationships among factors were also analyzed in this study by utilizing a combined behavioural model which was based on TPB and TAM. This study identified users' intention to use academic libraries according to changes in the use environment, and the findings of this study bring a valuable meaning to library administrators for setting up the strategic plan for the future of academic libraries. The results of this study imply that academic libraries should strategically setup an effective and efficient operating plan based on awareness, attention and cooperation, in order to survive as well as to accomplish balanced growth in rapidly changing environment.

모음에 따른 후두 교호운동 특성

한지연,이옥분,Han, Ji-Yeon,Lee, Ok-Bun 대한음성학회 2008 말소리 Vol.68 No.-

This study investigated the vowel effect on laryngeal DDK (L-DDK) in terms of rate, regularity, and range. Thirteen normal speakers participated in this experiment. Speakers were asked to repeat the vowels /a, e, i, o, u/ for vocal fold adduction DDK, and /ha, he, hi, ho, hul for vocal fold abduction DDK. Acoustic data was analyzed via Motor Speech Profile. There were 6 parameters: DDKavp and DDKavr for rate of L-DDK, DDKcvp and DDKjit for regulariry of L-DDK, and DDKavi and DDKcvi for range of L-DDK. Results of MANOVA and Fredman analysis showed no significant vowel effect on rate and regularity of L-DDK. MANOVA revealed significant effects of vowels and vocal fold ab/adduction on range of L-DDK. DDK peak intensity (DDKavi) in vowel /i/ production was lower than in vowels /a, e, o, u/. Variation of DDK peak intensity (DDKcvi) was significantly greater for /ha/ than for /a/ production. The implication of these findings on voice and speech pathology is discussed.

비유창성 화자의 후두 교호운동 특성

한지연,이옥분,박희준,임혜진,Han, Ji-Yeon,Lee, Ok-Bun,Park, Hee-Jun,Lim, Hye-Jin 한국음성학회 2007 음성과학 Vol.14 No.2

Laryngeal DDK involve with the rate, pattern, and regularity (periodicity) in opening and closing of vocal fold. This study was aimed at investigating the characteristics of laryngeal DDK between nonfluent and fluent speakers. One with an ataxic dysarthria (with cerebellar lesion) and the other with stuttering, and 13 normal speakers were evaluated. L-DDK were analyzed with MSP (motor speech profile, CSL 4400). Measures of DDK included: DDKavr, DDKcvp, DDKjit, DDKavp. An ataxic dysarthric speaker and a stutterer showed more reduced rate and aperiodic L-DDK (both adductory and abductory movement) than normal speakers. But the average L-DDK period (ms) in adductory movement in a speaker with stuttering showed more decreased than the other. Results from this study are preliminary. Nonetheless, results of L-DDK produced by nonfluent speakers suggested the possibility to have relation with slow rate of phonatory initiation and connected speech. In the future, perceptual studies are needed in conjuction with acoustic and speech production.

연속구어 내 발성 종결-개시의 음향학적 특징 - 말더듬 화자와 비말더듬 화자 비교 -

한지연,이옥분,Han, Ji-Yeon,Lee, Ok-Bun 한국음성학회 2006 음성과학 Vol.13 No.2

The purpose of this paper was to examine acoustical characteristics of phonatory offset-onset mechanism in the connected speech of female adults with stuttering and normal nonfluency. The phonatory offset-onset mechanism refers to the laryngeal articulatory gestures. Those gestures are required to mark word boundaries in phonetic contexts of the connected speech. This mechanism included 7 patterns based on the speech spectrogram. This study showed the acoustic features in the connected speech in the production of female adults with stuttering (n=1) and normal nonfluency (n=3). Speech tokens in V_V, V_H, and V_S contexts were selected for the analysis. Speech samples were recorded by Sound Forge, and the spectrographic analysis was conducted using Praat. Results revealed a stuttering (with a type of block) female exhibited more laryngealization gestures in the V_V context. Laryngealization gesture was more characterized by a complete glottal stop or glottal fry both in V_H and in V_S contexts. The results were discussed from theoretical and clinical perspectives.

PLA/PMMA/PBAT 블렌드의 상용성 및 조성에 의한 특성 연구

한지연,차주희,안승재,전한용,Han, Ji-Yeon,Cha, Ju-Hee,Ahn, Seung-Jae,Jeon, Han-Yong 한국섬유공학회 2015 한국섬유공학회지 Vol.52 No.4

The viscoelastic behavior and tensile properties of PLA blends and PLA/PMMA/PBAT blends were measured, and an image analysis was performed, to examine the compatibility of PLA, PBAT, and PMMA. PLA/PMMA blends were found to exhibit a high level of compatibility for all compositions. The thermal stability, modulus, and tensile strength of these blends increased with PMMA content. Also, the glass transition temperature and tensile strength of PLA/PMMA blends varied between the values for neat PLA and PMMA, indicating a high degree of compatibility. On the other hand, ternary blends of PLA, PMMA, and PBAT exhibited a low modulus than PLA/PMMA blends; their compatibility improved with PMMA content because of PMMA acting as a compatibilizer for PLA/PBAT blends.

수컷 생쥐 부속 생식샘의 형태에 미치는 에스트로겐 수용체 $\alpha$의 선택적 효능제 propyl pyrazole triol의 영향

한지연,조현욱,Han, Ji-Yeon,Cho, Hyun-Wook 한국현미경학회 2009 Applied microscopy Vol.39 No.1

본 연구에서는 에스트로겐 수용체 알파 효능제인 propyl pyrazole triol (PPT)을 수컷 생쥐에 투여하였을 때 부속 생식샘의 조직학적 변화가 유발되는지를 조사하였다. 광학현미경으로 조사하기 위해 수컷 생식기관을 고정, 탈수, 포매, 절편 과정을 거쳐 프레파라트를 완성하였다. PPT에 의해 복부쪽 전립샘, 정낭, 포피샘의 각 무게는 실험기간에 따라 감소되었다. 투여군의 경우, 복부쪽 전립샘의 샘 조직 내강은 위축되었다. 전립샘 상피조직의 형태가 단층 원주상피에서 중층 입방 상피 혹은 편평상피로 변화되었다. 투여군 전립샘과 정낭의 상피조직 아래에 있는 결합조직은 증가되었다. 특히, 투여군 정낭의 내강이 대조군에 비해 위축되었다. 포피샘의 투여군 8주에서 상피세포 높이가 감소되었다. 수컷 내에서 에스트로겐 수용체 효능제의 이런 영향을 파악함으로서 생식기관 내 에스트로겐의 생리학적 기능을 이해하는데에 도움을 줄 것으로 사료된다. This study investigated that exposure of male mice to estrogen receptor $\alpha$-selective agonist, 4,4',4"-(4-propyl-[1H]-pyrazole-1,3,5-triyl)tris-phenol (PPT) induce morphological changes of accessory genital glands. The male reproductive organs were fixed and processed for light microscopy. The PPT induced decreases of ventral prostates, seminal vesicles and preputial glands weights with experimental time. The glandular lumen of ventral prostate was atrophied compared with control group. Type of epithelial tissues in the prostate was changed from simple columnar epithelium to stratified cuboidal or squamous epithelium. Treated group with the agonist showed that increased connective tissue underlying epithelium in the prostate and seminal vesicle. Especially, the glandular lumen of the seminal vesicle was contracted when PPT-treated animals were compared with control group. Secretion cells of preputial gland were smaller than that of control group. On week 8, PPT treatment caused decrease of epithelial cell height lining the lumen of preputial gland. These results provide information useful in researching the physiological function of estrogen mediated by estrogen receptor $\alpha$ in male accessory genital gland.

암환자의 통증 조절

한지연,Han, Ji-Yeon 한국가톨릭호스피스협회 1995 호스피스 Vol.5 No.-

실크로드의 동서문화교섭이 불교의 중국화 과정에 미친 영향 - 돈황지역에 보이는 불교문화와 중국도교문화의 융합 사례를 중심으로 -

한지연 ( Han Jee-yeon ) 동아시아불교문화학회 2020 동아시아불교문화 Vol.0 No.41

This paper purports to review the role of the Silk Road, especially of Dunhuang region, in Buddhist entry and settlement in China by paying attention to the exchanges between Buddhist and Chinese Daoist elements. Until now, in historical interpretation, the understanding of Buddhist cultural history in the ancient and middle ages of China was unilaterally based on the ancient capital of Chang'an or Luoyang as the centers of Chinese history and culture. At the moment of incorporating the concept of 'exchange' into this perspective, however, the existing way of interpreting history should be restructured. This is because the acceptance, transformation, and ensuing development of the culture through exchanges are revealed as different from the existing understanding of its cultural history. This is a question of whether the product of exchanges is placed on the center of the traditional Han Chinese ideology, or whether the traditional Chinese ideology and the exchange process are mixed. In short, we will examine the process of the fusion of the Han dynasty primitive Daoist culture and Buddhist culture through the era from the later Han Dynasty to the five Liang states. And through this, we will expand the understanding of Chinese Buddhism by examining the process of how Dunhuang Buddhism is transplanted into China.