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- 저자 : 한구용(Ku Yong Hann) (검색결과 1 건)
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신현욱(Hyun Wook Shin),홍성우(Seong Wo Hong),장여구(Yeo Goo Chang),한구용(Ku Yong Hann),백인욱(In Wook Paik),이혁상(Hyucksang Lee) 대한외과학회 2007 Annals of Surgical Treatment and Research(ASRT) Vol.73 No.1
Purpose: Thrombocytosis is commonly associated with various tumors, including stomach, ovarian, lung, liver and pancreas cancers. Some clinical reports have shown thrombocytosis to be associated with the disease stage and prognosis. This study investigated the prevalence of the thromobocytosis in patients with colorectal cancer, and its association with the prognosis. Methods: Two hundreds ninety-six patients with colorectal cancer who had been surgically treated at our hospital between 1997 and 2004 were enrolled in this study. The incidence, relationship with other clinicopathological factors, and the prognostic value of thrombocytosis were evaluated retrospectively. Results: Thirty-seven of the 290 (12.8%) patients had thrombocytosis. The incidence of thrombocytosis was examined with regard to gender (P=0.018), tumor location (P=0.021), and T stage of tumor (P<0.000). Univariate analysis demonstrated thromobocytosis, T stage, N stage, M stage, venous invasion, lymphatic invasion, and elevated carcinoembryogenic antigen (≥5 ng/ml) to be associated with both the disease-free survival (DFS) and overall survival (OS). Multivariate analysis revealed thrombocytosis to be significantly associated with the disease-free survival (P=0.026). Conclusion: Preoperative thrombocytosis appears to be an independent prognostic indicator of the DFS in patients with colorectal cancer.
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