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- 저자 : 한경주(Han Kyungju) (검색결과 3 건)
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한경주(Han KyungJu),황혜숙(Hwang HyeSuk),김유성(Kim YuSung),이지은(Lee JiEun),정상용(Jeong SangYong),류연희(Ryu YeonHe),최선미(Choi SunMi),구성태(Koo SungTae) 한국한의학연구원 2007 한국한의학연구원논문집 Vol.13 No.2
The aim of the study was to analyze recent trends of experimental studies regarding to acupuncture and moxibustion (AM) through reviewing the 492 papers in the PubMed database in order to help researchers from overlapping study on the same theme and to spur them to investigate experimental studies on AM with understanding the current flow of that. For the analysis, we include papers in which abstract was written in English. First, we performed quantitative analysis of the experimental studies using whole of the first filtrated 492 papers. From this analysis, we could obtain the followings: "Trends of study in the most frequently appeared journals and leading authors in experimental study of AM", "The number of papers and name of journals by leading authors in experimental study of AM", "Trends of Korean papers in the most frequently appeared journals and Korean leading authors in experimental study of AM", "Classification of experimental studies related to acupuncture and moxibustion according to intervention methods or individual country" and "Assortment of experimental studies related to acupuncture and moxibustion in terms of intervention methods on leading countries". Second, we collected 72 papers considering impact factor of the journal and influential effect of the papers' result for qualitative analysis, and we divided the papers into pain related one or not, because the effect of AM on pain is major subject of AM study. The results showed that experimental studies regarding to AM still has several weakness such as limited usage of acupuncture points and inclined application of electroacupucture even though there are 361 acupuncture points in the human body and various kinds of stimulation methods using traditional needles and moxibustion. Therefore, we suggest that researchers should pay more attention to the study on basic AM research creatively and systematically through strengthening and enhancing the cooperation among colleges, research institutes and hospitals. Moreover, in order to promote the basic research of the AM, it is required that we need cross-disciplinary research as well as international collaboration research.
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전침자극이 자연 발증 고혈압 흰쥐의 혈압 조절 중추에서 iNOS의 발현에 미치는 영향
황혜숙(Hwang Hyesuk),김유성(Kim Yusung),이지은(Lee Jieun),한경주(Han Kyungju),최선미(Choi Sunmi),구성태(Koo Sungtae) 한국한의학연구원 2006 한국한의학연구원논문집 Vol.12 No.3
Aims: Acupuncture has been used for the treatment of essential hypertension, but the efficacy and the mechanism of acupuncture in prevention of hypertension are still unclear. We tested the hypothesis that electroacupuncture (EA) applied to Baekhoe (GV20) changes NO/NOS system during development of hypertension in spontaneously hypertensive rats (SHR) , and thereby causes the delay of development of hypertension in SHR. Methods: The male SHR rats in the developmental stages of hypertension (7-8 weeks) were randomly divided into three groups (control group, GV20 acupuncture group, and tail acupuncture group). And the age matched Wistar Koyto Rats (WKY) were randomly divided into two groups (negative control, GV20 acupuncture group). EA treatments (10Hz, 1mA, 0.1ms) were carried out for 25 mini day for five consecutive days. The systolic blood pressure (SBP) was determined in conscious rats by the tail-cuff method using automatic BP mornitoring system. We investigated the activations of inducible NO synthase (iNOS) in nuclei of solitary tract (NTS) and rostral ventrolateral medulla (RVLM) of SHR by the western blotting method. Results: The SBP after the termination of EA stimulation applied to the GV20 was stabilized at 169.14±3.67 ㎜Hg which is lower value than that of the control group. The SBP of control group was elevated to 178.14±3.49 ㎜Hg. In addition, we evaluated NOS activity as well as iNOS protein expression of NTS and RVLM in both of SHR and WKY. The iNOS activity in NTS was significantly higher in SHR than in WKY. Furthermore, the iNOS activity of NTS showed significant decreases in EA groups compare to that of non treated SHR group. Although iNCS expression of RVLM showed non significant changes between SHR and WKY, EA significantly enhanced the iNCS expression in SHR. Our data support the hypothesis that delayed development of hypertension and altered iNOS expression of NTS and RVLM by EA stimulations in SHR rats. Conclusions: The findings demonstrate that acupuncture can change NO/NCS system in NTS and RVLM, and exert beneficial role on development of hypertension.
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박지은(Park jieun),오달석(Oh dalseok),신선화(Shin seonhwa),최준용(Choi junyong),구창모(Koo changmo),김애란(Kim aeran),정소영(Jung soyoung),한경주(Han Kyungju),최선미(Choi sun-mi) 한국한의학연구원 2007 한국한의학연구원논문집 Vol.13 No.2
Objective : This study was aimed to review the trend of clinical research articles of acupuncture and moxibustion from the year of 1995 to 2006. Methods : The retrieving and analyzing period were from January 1995 to July 2006. Articles were collected by retrieving Pubmed database. Search terms were as follows; "Acupuncture", "Acupuncture & Meridian", "Moxibustion". After reviewing articles by our pre-defined criteria, Correlation was assessed qualitatively between contents of the final selected articles and those of Korea Institute of Oriental Medicine. Results : The number of acupuncture research articles have increased with higher rate since the year of 2000. In the field of medical devices, the articles were sparsely existed. The percentage of clinical acupuncture research articles was 75%. However, in the category of Korean investigators' researches, it was 46%. Publications by Korean investigators were concentrated to several specific journals of which their impact factor were below 1 point. Conclusion : There needs more qualifying studies in acupuncture studies which are represented by impact factor in Journal Citation Reports. It is necessary to research and develop the medical devices quantatively rating the outcome of acupuncture trials. The secondary research, such as, systematic reviews, meta-analysis, would be a key approach to evaluate the effectiveness and safety of acupuncture treatments. Moxibustion research would be noticeable in regard to its historical effectiveness and its variable indications.
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