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위암, 대직장암 환자에서 혈청 CEA 및 CA 19-9의 수술전 및 수술 후의 변동에 관한 연구
하홍근,이승도 고신대학교 의학부 1989 高神大學校 醫學部 論文集 Vol.5 No.1
The levels of CA 19-9 and CEA were studied in 374 cases of stomach and 68 cases of colorectal cancer. The results are as follows. 1. The sensitivity of preoperative CA19-9 level was as 21.8% in stomach cancer, 37.5% colorectal cancer and the sensitivity of preoperative CEA level was 25.8% in stomach cancer and the sensitivity of preoperative CEA level was 25.8% in stomach cancer and 51.5% in colorectal cancer. 2. In stomach cancer, the positive rate of preoperative CA19-9 level was 4.1% in stage Ⅰ, 24.0% in stage Ⅱ, 25.7 in stage Ⅲ, 32.9% in stage Ⅳ and positive rate of preoperative CEA level was 10.8% in stage Ⅰ. 25.0% in stage Ⅱ, 25.6% in stage Ⅲ, 40.6% in stage Ⅳ. 3. In colon cancer, positive rate of CA 19-9 was 9.0% in Dukes A, 15.4% in Dukes B, 35.0% in Dukes C, 33.3% in Dukes D and positive rates of preoperative CEA level were 7.6% in Dukes A, 50.5% in Dukes B, 73.1% in Dukes C, 53.1% in Dukes D. 4. The recurrence rate of stomach cancer was 71.4% in the cases of positive preoperative CA19-9 lever and 32.1% in the cases of negative preoperative CA19-9 level, which was stastically significant(P<0.025). The Recurrence rates of stomach cancer was 52.4% in the cases of positive, preoperative CEA level and 25.0% in the cases of negative preoperative CEA level which was also stastically significant. 5. The sensitivity of CA19-9 level of detection of recurrence was 75% in the cases of positive preoperative CA19-9 level, 46.2% in the cases of negative, preoperative CA19-9 level and 97.1% in the cases of negative preoperative CA19-9 level. 6. The sensitivity of CEA level for detection of recurrence was 87.5% in the cases of negative preoperative CEA level and specificity was 37.5% in the cases of positive preoperative CEA level and 10.3% in the cases of negative preoperative CEA level.