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Phillyrin의 HepG2 세포에서 포도당신생합성에 대한 영향
이기호,타이투엣난,정혜광 忠南大學校 醫藥品開發硏究所 2019 藥學論文集 Vol.34 No.-
Type II diabetes mellitus (T2DM) is a chronic metabolic disease caused by insulin resistance, and its worldwide prevalence has dramatically increased over the past few decades. Increased glucose production through abnormally elevated hepatic gluconeogenesis is central to the manifestation of hyperglycemia in T2DM. Phillyrin, one of the major active constituents of Forsythia suspensa and Forsythia koreana, has been reported to possess the anti-inflammatory and anti-oxidant effects. However, the effect of phillyrin on anti-diabetes mellitus activity and its underlying molecular mechanisms have not been elucidated. In this study, we investigated the inhibitory effects of phillyrin on hepatic gluconeogenesis in HepG2 cells. Phillyrin attenuated forskolin-induced phosphoenolpyruvate carboxykinase (PEPCK) and glucose 6-phosphatase (G6Pase) mRNA expression, major genes in hepatic gluconeogenesis. Furthermore, phillyrin suppressed the forskolin-induced phosphorylation of PKA and CREB, major regulators of glucose metabolism, to modulate hepatic gluconeogenic gene expression. Together, these results suggest that phillyrin could inhibit hepatic gluconeogenesis via PKA/CREB pathway in HepG2 cells.