http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
박노상(No Sang Park),김현숙(Hyun Sook Kim),민창희(Chang Hee Min),최중권(Joong Kwon Choi) 대한약학회 1990 약학회지 Vol.34 No.2
3-Substituted 5-aminoisoxazole-4-carboxylates were prepared by the reaction of corresponding bormoaldoximes with cyanoacetate. The 3-trifluoromethylisoxazole derivatives were acylated to amides with various aminopyridine derivatives to afford diamides. The ester group was hydrolyzed and decarboxylated easily to give 3-trifluoromethyl-5-aminoisoxazole. The aminoisoxazole was also converted to amides. 5-Amino-3-trifluoromethylisoxazole-5-one-4-carboxylate was prepared by the reaction of trifluoroacetoaldoximoyl bromide and malonate. 5-Amino-3-methylisoxazole-5-one-4-acetate was prepared by the reaction of hydroxylamine and acetylmalonate. The synthesized compounds were tested for antiinflammatory activities.
박노상(No Sang Park),김현숙(Hyun Sook Kim),임희종(Hee Jong Lim),정영식(Young Shik Jung),최중권(Joong Kwon Choi),함원훈(Won Hoon Ham) 대한약학회 1991 약학회지 Vol.35 No.2
Quinoline, pyrazolo-[5,4-b]-pyridine, isoxazolo-[5,4-b]-pyridine, pyrazolo-[4,3-c]-quinoline, isoxazolo-[5,4-e]-thiazine, and isothiazolo-[5,4-e]-thiazine derivatives were prepared as possible antiinflammatory agents. Some of the synthesized compounds showed antiinflammatory activities comparable to Aspirin and Naproxen.