간장장애 가토에서 베라파밀의 약물동태

최준식,김형중,Choi, Jun-Shik,Kim, Hyung-Jung 한국임상약학회 2004 한국임상약학회지 Vol.14 No.1

The purpose of this study was to investigate the pharmacokinetic changes of verapamil in rabbits with hepatic disorder induced by carbon tetrachloride. The plasma concentrations of verapamil were increased significantly (p<0.05, in slight group; P<0.01, in moderate and severe group) in all groups of hepatic disorder compared to the control group. Morover, the $C_{max}\;in\;slight\;(77.9\%$ increase), moderate ($110\%$ increase), and severe ($174\%$ increase) hepatic disorder groups were significantly (p<0.05, in slight; p<0.01, in moderate and severe) higher than that in control rabbits. These resulted in significantly (p<0.05, in slight; p<0.01, in moderate and severe) greater area under the plasma concentration-time curve (AUC) in moderate ($49.8\%$ increase), moderate ($95.0\%$ increase), and severe ($144\%$ increase) hepatic disorder groups than that in control rabbits. Hence, the relative bioavailability values were 149, 195, and $244\%$ for slight, moderate, and severe hepatic disorder groups, respectively. This could be due to decrease in metabolism of verapamil in the liver because of suppressed hepatic function in the hepatic disorder groups because verapamil is mainly metabolized in the liver.

위암 환자에서 반코마이신의 임상약물동태

최준식,장일효,범진필,Choi, Jun-Shik,Chang, Il-Hyo,Burm, Jin-Pil 대한약학회 1997 약학회지 Vol.41 No.2

The purpose of this study was to determine pharmacokinetic parameters of vancomycin using two point calculation(TPC) and Bayesian methods in 16 Korean normal volunteers and 15 g astric cancer patients. Nonparametric expected maximum(NPEM) algorithm for calculation of population pharmacokinetic parameter was used, and these parameters were applied for clinical pharmacokinetic parameters by Bayesian analysis. Vancomycin was administered 1.0g every 12 hrs for 3 days by IV infusion over 60 minutes. The volume of distribution(Vd), elimination rate constant(Kel) and total body clearance(CLt) of vancomycin in normal volunteers using TPC method were $0.34{\pm}0.06 L/kg,\; 0.19{\pm}0.01 hr^{-1}$ and $4.08 {\pm} 0.93 L/hr$, respectively, The Vd, Kel and CLt of vancomycin in gastric cancer patients using TPC method were $0.46 {\pm} 0.06 L/kg, 0.17{\pm}0.02 hr^{-1}$ and $4.84 {\pm} 0.57 L/hr$ respectively. There were significant differences(p<0.05) in Vd. Kel and CLt between normal volunteers and gastric cancer patients. Polpulation pharmacokinetic parameter, the slope(KS) of the relationship beetween Kel versus creatinine Clearance, and the Vd were $0.00157{\pm}0.00029(hr{\cdot}mL/min/1.73m^2)^{-1},\; 0.631 {\pm} 0.0036 L/kg$ in gastric cancer patients using NPEM algorithm respectively. The Vd and Kel were $0.63{\pm}0.005 L/kg, 0.15 {\pm}0.027 hr^{-1}$ for gastric cancer patients using Bayesian method. There were significant differences(p<0.05) in vancomycin pharmacokinetics between Bayesian and TPC methods. It is considered that the population parameter in the patient population is necessary for effective Bayesian method in clinical pharmacy practise.

Low Molecular Weight Polyethylenimine-Mitochondrial Leader Peptide Conjugate for DNA Delivery to Mitochondria

최준식,Min Ji Choi,고경수,이병두,김영미,In Seok Bang,이민형 대한화학회 2006 Bulletin of the Korean Chemical Society Vol.27 No.9

It has been found that a number of diseases are associated with mutations in the mitochondrial DNA. Therapeutic gene delivery to mitochondria has been suggested as a clinical option for these diseases. In this study, we developed a gene carrier to mitochondria by the conjugation of mitochondrial leader peptide (LP) to polyethylenimine (PEI). Mitochondrial LP conjugated PEI (PEI-LP) was synthesized with low molecular weight PEI (2,000 Da, PEI2K). Gel retardation assay showed that PEI2K-LP formed complexes at a 1.0/1 weight ratio. In addition, PEI2K-LP protected DNA from the enzymatic degradation for at least 60 min, while naked DNA was completely degraded within 20 min. PEI2K-LP was compared with LP conjugated high molecular weight PEI (25,000 Da, PEI25K) in terms of toxicity and delivery efficiency. MTT assay showed that PEI2K-LP had much lower cytotoxicity than PEI25K-LP to 293 cells. In addition, cell-free DNA delivery assay showed that PEI2K-LP delivered more DNA to mitochondria at a 1.8/1 weight ratio than naked DNA or PEI. This result suggests that PEI2K-LP may be useful for the development of mitochondrial gene therapy system with lower cytotoxicity.

Probenecid와 Nalidixic Acid의 약물상호작용(藥物相互作用) ( II )

최준식,이진환,김용현,이민화,Choi, Jun-Shik,Lee, Jin-Hwan,Kim, Yong-Hyun,Lee, Min-Hwa 한국약제학회 1983 Journal of Pharmaceutical Investigation Vol.13 No.4

The interaction between probencid and nalidixic acid was studied pharmacokinetically in rabbits infused with or without acidic soiution (5% $NH_4Cl$). The results were as fellows. The blood level and the area under the blood concentration curve of nalidixic acid administered intravenously was elevated by coadministration of probenecid and more elevated in rabbits infused with acidic solution. Probenecid inhibited the urinary excretion of nalidixic acid in rabbits infused with adidic solution. Therefore, biolgcal half-life of nalidixic acid was prolonged by coadministration of probencid.

푸로푸라놀롤과 안지오텐신 차단제와의 체내 상호작용

최준식,이진환,범진필,Choi, Jun-Shik,Lee, Jin-Hwan,Burm, Jin-Pil 한국약제학회 1990 Journal of Pharmaceutical Investigation Vol.20 No.1

Effect of an angiotensin inhibitor (AAS; loading dose of 25, 50, $100{\mu}g/kg$ and maintenance dose of 12.5, 25,$50{\mu}g/ka/hr$) on the pharmacokinetics of propranolol (4 mg/kg i.v.) was studied in rabbits. Plasma concentrations and relative bioavailability of propranolal increased upto 127-175% by AAS coinjection. The urinary excretion of propranolol decreased by AAS. Dosage regimen of propranolol should be adjusted when it is administered with AAS.

시판 이소니아짓 정제의 생물학적 동등성시험에 관한 연구

최준식,안선엽,Choi, Jun-Shik,An, Seon-Yeob 대한약학회 1989 약학회지 Vol.33 No.4

Even though two different preparations are chemically equivalent, the variance of bioavailability differenciates the clinical effect of preparations, so that the preparations need to be evaluated by comparing bioavailability in vivo as well as chemical equivalence. In this study, bioequivalence tests of commercially available isoniazid tablets A, B, C and D (standard) were performed to give some guidelines to bioequivalence test. The bioavailability parameters obtained by drug administeration were statistically analyzed. Statistical evaluation of the data involved an analysis of variance for a cross over design. Cross over design was employed with 8 healthy volunteers. The results were within 20% difference of mean value in the AUC, Cmax, Tmax and amount of urinary excretion (Au) between standard and isoniazid tablets. The results of ANOVA showed no significant differences for 'group or sequence', but almost not for 'between subjects'. The tablet. A, B and D were within 20 min, but tablet C was within 50 min. Tablet A was biologically equivalent in the Au. tablet B biologically equivalent in the Au and AUC. Tablet C was biologically equivalent in the Au. The relationship between the dissolution rate and Au was significant.

창의력 증진을 위한 놀이 및 교육용 모듈러 로봇 개발

최준식,이보희,김진걸,Choi, Joon-Sik,Lee, Bo-Hee,Kim, Jin-Geol 한국전기전자학회 2014 전기전자학회논문지 Vol.18 No.4

본 연구에서는 교육 및 놀이를 통해 창의력 증진이 가능한 재구성 모듈러 로봇에 대하여 다루고 있다. 보통 모듈러 로봇은 각각 셀들의 조합으로 변형 재구성하고 다양한 형태의 구조를 만드는데 적합한 로봇으로 설계되어 있지만 이를 이용하여 교육과 놀이를 주제로 한 연구는 국외에 소수 있으며 국내에는 전무하다. 제안하는 형태는 기존 모듈러 로봇과 같이 같은 동작만 반복하는 모듈이 아니라 소리를 내는 소리모듈, 바퀴가 달린 바퀴모듈, 시각적 표현을 위한 LED모듈, 전원공급을 위한 전원모듈, 통신을 위한 블루투스모듈, 움직이는 동작을 구현 가능하도록 하는 관절모듈이 있는 구조로 설계되어 있다. 이와 같은 다른 능력이 부여된 각 모듈의 다양한 결합을 이용하여 창의적 활동이 가능하도록 하고, 아이들이 쉽게 사용 할 수 있도록 한다. 본 연구에서는 모듈별 각기 다른 능력을 부여하여 교육과 놀이가 가능하도록 하는 방식의 모듈러 로봇의 설계 및 동작을 다루고 있다. 그리고 연구된 동작은 실제 제작 및 실험을 통해 동작의 유용성을 보였다. This study deals with reconfigurable modular robot with respect to the compact and capability of representing the various actions for promoting creativity through education and play. Generally modular robot can be designed as a suitable robot that is transformed to various structure by reconstructing each cells, However, there are only few research on the education and play using those robots in the world and still nothing domestically. Unlike the existing modular robots only having a repeating motion, the proposed modular works by individual module such as sound is produced by sound module, wheel is driven by wheel module, LED module controls the visual expression, power is supplied by battery module, bluetooth module for communication, and dynamic motion realization is possible by using joint module. By manipulating the abilities endowed by individual modules, diversity of creative activities is possible and thus made an easy access for children. This study deals with the design of modular robotic by using the variety of different modules to endowed the learning and playing ability. And the study showed the utility of the operating behavior over the actual production and testing.

Characterization of Linear Polymer-Dendrimer Block Copolymer/Plasmid DNA Complexes: Formation of Core-shell Type Nanoparticles with DNA and Application to Gene Delivery in Vitro

최준식,Young Hun Choi,Jong Sang Park* 대한화학회 2004 Bulletin of the Korean Chemical Society Vol.25 No.7

엽산으로 유도된 신장장애 가토에서 정맥투여시 딜터아젬과 활성대사체인 데아세델딜터아젬의 약물동태

최준식,범진필,Choi, Jun Shik,Burm, Jin Pil 한국임상약학회 2000 한국임상약학회지 Vol.10 No.3

Diltiazem inhibits calcium channels and leads to vascular smooth muscle relaxation and negative inotroic and chronotropic effects in the heart. Diltiazem (DTZ) is almost completely absorbed after oral administration, but its bioavailability is reduced because of considerable hepatic first-pass metabolism. The main metabolite of DTZ is deacetyldiltiazem. The purpose of this study was to report the pharmacokinetic changes of DTZ and its metabolite, deacetyldiltiazem (DAD) after intravenous administration of diltiazem to control rabbits and rabbits with mild and medium folate-induced renal failure (FIRRs). The area under the plasma concentration-time curves (AUC) of DTZ were significantly increased in mild and medium FIRRs. The metabolite ratio of the DAD to DTZ were significantly decreased in mild and medium FIRRs. The elimination rate constant $(\beta)$ and total body clearances (CLt) of DTZ were significantly decreased in mild and medium FIRRS. These findings suggest that the hepatic metabolism of diltiazem was inhibited and CLt and ${\beta}$ of DTZ were significantly decreased in mild and in rabbits with medium folate-induced renal failure.

자연어처리 기반 콘텐츠 범주화 및 재생산에 대한 연구

최준식 ( Junsik Choi ),이서영 ( Seoyoung Lee ),임인호 ( Inho Lim ),김영종 ( Youngjong Kim ) 한국정보처리학회 2019 한국정보처리학회 학술대회논문집 Vol.26 No.1

다양한 요약 프로그램이 존재하지만 입력되는 정보의 형태가 텍스트에 한정되어있다. Sumalyze는 그러한 한계점을 보완한 파이썬 언어 기반 라이브러리다. 다양한 형식의 데이터를 입력받으며 컨텐츠의 종류에 맞는 요약과 범주화를 제공한다. 또한, 컨텐츠의 핵심파악을 돕기 위해 요약에 대한 분석을 제공한다.