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RISS 인기검색어
- 검색키워드
- 저자 : 최원영(Won Young Chey) (검색결과 2 건)
- 무료
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당뇨환자에서 Itraconazole 의 효용성과 안정성
최원영(Won Young Chey),김영걸(Young Gull Kim),이애영(Ai Young Lee),정의창(Eui Chang Chung) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.8
N/A Introduction : As the number of diabetics increase with younger onset and longer duration, patients are confronted with higher incidence of diabetes related complications such as distal extremity vasculopathy, neuropathy and various infectious diseases. Such diabetics are more prone to a much higher rate of onychomycosis compared to normal subjects and because this could trigger irreversible consequences, confirmation of fungal involvement should be promptly taken care of. Itraconazole is a widely used drug nowadays and compared to drugs such as griseofulvin and ketoconazole, has many advantages in efficacy, cost, duration of therapy which eventually results in better patient compliance. Objective : Our study was designed to better dictate the usage of itraconazole in diabetics so these patient can receive quality treatment when it is needed. Method : The study consisted of 101 patients with both onychomycosis and diabetes who were receiving treatment in Eulji hospital. They all received 3 pulses of itraconazole and were evaluated for efficacy and safety of their treatment. The patients were observed on routine examinations for 36 weeks and at their visits they were interviewed and received microscopic examinations. Result : Eighty four percent of the patients showed clinical and mycological improvement with 33% of them showing total clearance. There were no hypo-or hyperglycemic events and 17 patients complained of mostly mild side effects such as indigestion. Two patients dropped out of the study due to epigastric pain and peripheral extremity swelling. Conclusion : The use of itraconazole in the treatment of onychomycosis seemed to be effective and relatively safe for diabetics.
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Cytochrome p450 동위효소를 통한 고정약진의 원인규명에 관한 연구
이애영(Ai Young Lee),김민정(Min Jung Kim),이강은(Kang Eun Lee),최원영(Won Young Chey),최준(Jun Choi) 대한피부과학회 2001 大韓皮膚科學會誌 Vol.39 No.11
N/A The reasons of same site recurrence in fixed drug eruptions (FDEs) remain to be clarified. Although the nature of antigen in FDE is unknown, drug metabolites could play a role for antigen formation. Cytochrome p450 isozymes (CYPs) are important enzymes for drug metabolism. This study was done to examine the role of CYPs in FDEs. Provoked lesion was compared with non-provoked lesion by the same drug on the same patient to overcome inter-individual variations of CYPs. The reverse transcriptase-polymerase chain reaction (RT-PCR) with primers for CYPs and the immunohistochemistry (IHC) with anti-CYPs, pancytokeratin, and leukocyte common antigen (LCA) antibodies were conducted. The causative drugs were different in 13 patients who conducted RT-PCR, and the result could not be analyzed by the cause. The levels of CYP2C8/19 and CYP2E1 mRNAs increased significantly in provoked lesions. The keratinocytes in cases of mefenamic acid-induced FDEs stained strongly with anti-CYP2C9 antibody not with the other three antibodies (CYP1A1, CYP2E1, and CYP3A4), The FDE cases from doxycycline, which is not metabolized by CYP2C9 enzyme, and those from chlormezanone did not react to anti-CYP2C9 antibody, The cells stained with CYP antibodies did not react with anti-LCA antibody but with anti-pancytokeratin antibody. The number of cells which reacted to anti-LCA antibody clearly increased in the provoked lesions, regardless of the cause. The above results suggest that CYPs may contribute the drug antigen formation and different levels of CYPs between provoked and non-provoked lesions can play a role for the same site recurrence of lesions in FDEs.
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