한방병원(韓方病院) 소아과(小兒科) 입원(入院) 환자(患者)의 주소증(主訴證)에 대한 연구(硏究)

천진홍,유현영,김기봉,민상연,김장현,Cheon, Jin-Hong,Yu, Hyun-Young,Kim, Ki-Bong,Min, Sang-Yeon,Kim, Jang-Hyun 대한한방소아과학회 2009 대한한방소아과학회지 Vol.23 No.3

Objectives The purpose of this study is to collect the statistics of pediatric problems and to develop more effective oriental medical treatments for pediatric diseases, their clinical applicability, and chief complaints on pediatric inpatients in oriental hospitals. Methods The study was composed of seventy inpatients that were age from 0 to 20, had received hospital treatment at the pediatrics in Dongguk Bun-Dang Oriental Medicine Hospital for seven years from 1 January 2002 to 31 December 2008. The chief complaints were mainly categorized by oral examination on their patients. Results 1. In this study, male children were thirty one and female children were 39. Thus, sex ration of male to female was 0.79:1. 2. In age distribution, one month to one year were three (4.3%), 1 to six years were forty two (60%), six to ten years were fifteen (21.4%), and ten to twenty years were ten (14.3%). 3. In November, the number of inpatients was the highest (15.7%) in a year. However, there were no significant seasonal differences. 4. In the systemic division, the respiratory diseases : 44(62.9%), the digestive diseases : 11(15.7%), the infectious diseases : 5(7.1%), the musculoskeletal diseases : 3(4.3%), the diseases of nervous system : 3(4.3%), the gynecologic diseases : 1(1.4%), the liver and biliary disorders : 1(1.4%), and etc. : 3(4.3%). 5. The chief complaint of the inpatients is pneumonia, a common cold, respiratory complex symptoms, rhinitis, sinusitis, bronchitis, tonsillitis, diarrhea and etc. Conclusions The two main causes of inpatients were respiratory diseases and digestive disease. More data of inpatients are required for further study. Thus, the new diseases and treatment methods should be studied as a field of oriental medical treatment.

한의학 관련 특허 중 소아 관련 특허동향 연구 - 국내 등록 특허를 중심으로 -

천진홍,김기봉,정아람,Hong, Cheon Jin,Kim, Ki Bong,Ram, Jeong A 대한예방한의학회 2014 대한예방한의학회지 Vol.18 No.2

Objective : The purpose of this study is to analyze for the patent application tendency in Korean Oriental Pediatric Medicine. Recently, many studies are published in Korean Oriental Pediatric Medicine. However, in the patent area, the research results are few. Method : For patent analysis, we searched the database kipris (http://www.kipris.or.kr) which managed in the Korean Intellectual Property Office by keywords about Korean Oriental Pediatrics. They are technically analysed by year and IPC, patent's contents, main applicant and organization. Results : 1. Patents by year have been on the rise 2 in 1997 to 32 in 2011. 2. Our findings are Section A61;182, A23;46 in IPC analysis 3. In classification of content, 'application-food' is 67 cases, 'application-functional cosmetic' is 18 cases, 'application-clothes' is 5 cases. 4. Korea Institute of Oriental Medicine have 14 patent cases, that is the most patent agency in possession. Main applicants are person > company > university > laboratory > state or local government. Conclusion : This study shows that it has high frequency of daily necessity in patent cases about oriental pediatrics. The results are more distributed 'applied' field than 'treatment' field. The patent information should be connected research achievement results in Korean Oriental Medicine.

한약인성 간손상의 원인산정법으로 도입된 진단 척도(Modified RUCAM scale)에 대한 임상적 고찰

천진홍,민상연,김장현,Cheon, Jin-Hong,Min, Sang-Yeon,Kim, Jang-Hyun 대한한방소아과학회 2008 대한한방소아과학회지 Vol.22 No.3

Objectives : The purpose of this study is to confirm severe problem caused by using a modified RUCAM scale than that officially recognized to diagnose liver injury induced by herbal medicine. Materials and Methods : Cases with liver injury induced by herbal medicine received to a related institute from January 2004 to December 2007 were collected and evaluated by the original scale and modified scale. Results : 1. Based on this study, we couldn't clinicaly confirm that the case was not excluded by the relieved first item basis of modified RUCAM scale which has to be excluded by the first item basis of orginal RUCAM scale. 2. By modified 6th item, one score was added to the total score. 3. By adding 8th item, it gaind one point to the whole the total score. Conclusions : In this study, we can clinically confirm that the modified RUCAM application to case with liver injury induced by herbal medicine is a severe problem.

자음강화탕(滋陰降火湯)이 호흡기 점액의 생성 및 분비에 미치는 영향

천진홍,민상연,김장현,Cheon, Jin Hong,Min, Sang Yoen,Kim, Jang Hyun 대한한방소아과학회 2016 대한한방소아과학회지 Vol.30 No.2

Objectives In this study, the effects of Ja-eum-gang-hwa-tang (JGT) on the increase in airway epithelial mucosubstances of rats and ATP- or PMA- or EGF- or TNF-${\alpha}$-induced MUC5AC mucin production and gene expression from human airway epithelial cells were investigated. Materials and Methods Hypersecretion of airway mucus was produced by exposure of $SO_2$ to rats for 3 weeks. The effect of orally-administered JGT for 2 weeks on increased epithelial mucosubstances from tracheal goblet cells of rats was assessed by using histopathological analysis after staining the epithelial tissue with Hematoxylin-eosin and PAS-alcian blue. Possible cytotoxicity of JGT was assessed by investigating the potential damage on kidneys and liver functions by measuring serum GOT/GPT activities and serum BUN concentration of rats and the body weight gain during experiment. Also, the effect of JGT on ATP- or PMA- or EGF- or TNF-${\alpha}$-induced MUC5AC mucin production and gene expression from human airway epithelial cells (NCI-H292) were investigated. Confluent NCI-H292 cells were pretreated for 30 min in the presence of JGT and treated with ATP ($200{\mu}M$) or PMA ($10ng/ml$) or EGF ($25ng/ml$) or TNF-${\alpha}$ (0.2 nM) for 24 hrs to assess the effect of JGT both on ATP- or PMA- or EGF- or TNF-${\alpha}$-induced MUC5AC mucin production by using enzyme-linked immunosorbent assay (ELISA) and on gene expression by the same inducers using reverse transcription-polymerase chain reaction (RT-PCR). Results (1) JGT decreased the amount of intraepithelial mucosubstances of trachea of rats. (2) JGT did not show any renal and hepatic toxicities, and did not affect body weights either. (3) JGT significantly inhibited ATP-, PMA-, EGF-, and TNF-${\alpha}$-induced MUC5AC mucin productions from NCI-H292 cells. (4) JGT inhibited EGF-, and PMA-induced expression levels of MUC5AC gene in NCI-H292 cells. However, ATP- and TNF-${\alpha}$-induced MUC5AC gene expression levels were not affected in NCI-H292 cells. Conclusions The result from the present study suggests that JGT might control the production and gene expression of airway mucin observed in various respiratory diseases which accompanied by mucus hypersecretion. Also, JGT did not show liver toxicity or impact on kidney functions. The effect of JGT should be further studied by using animal experimental models which can show proper pathophysiology of airway diseases.

제6 뇌신경 마비로 진단된 마비성(痲痺性) 사시(斜視) 환아(患兒) 1례(例) 보고(報告)

천진홍,민상연,김장현,Cheon, Jin-Hong,Min, Sang-Yeon,Kim, Jang-Hyun 대한한방소아과학회 2010 대한한방소아과학회지 Vol.24 No.3

Objectives: This study is to report a case of the paralytic strabismus with herbal medicine and acupuncture. Strabismus refers to the oculomotor muscles imbalance resulted from improper alignment of the visual axis of the two eyes. Our goal is to know the effectiveness and safety in children from oriental medicine. Methods: We treated the case by using herbal medicine, acupuncture, and etc. Results: We found that the case was recovered perfectly in short term(24days) without any side effects or complaints. Therefore, we try to apply this treatment in many children cases and to set as a guideline protocol to treat for children. Conclusions: The case showed proper oriental medical treatment is better choice for therapy than surgery or observation.

한방 영유아 건강검진 도입 필요성 연구

유승주,천진홍,김기봉,Yu, Seung Ju,Cheon, Jin Hong,Kim, Ki Bong 대한한방소아과학회 2016 대한한방소아과학회지 Vol.30 No.2

Objectives This study is to analyze current guidelines for health check-ups in infants and children, and to develop better guidelines based on oriental medicine. Methods We analyzed The Manual of 2015's Health Examination for Infants and Children which is a Korean Developmental Screening Test for Infants and Children (K-DST). The statistics from the test was collected from 2010 to 2014 to figure out the problems of Health Examinations for Infants and Children. 20 articles from 2000 to 2014 from RISS, NDSL were also analyzed. Results The current guidelines for health examinations in infants and children didn't include major pediatric diseases such as allergy and asthma. Also, the pediatrics health education materials were mainly focused on hypernutrition but not so much on nutrition deficiency. The number of the centers for Health Examinations for Infants and Children was 52.2% of the number of NIP-Participating medical institutions for infants and children. Conclusions Oriental medicine can be useful to prevent major pediatric diseases and to promote general health in pediatrics. By legislating 'Geon-a-beop', which is a law for infants and children, we can increase the number of medical centers for infants and children to get health check-ups. Currently, there are 9,769 Korean medical institutions, and the rate of traditional medical doctors of public health doctors was 25.5%. Weak Children Questionnaire is developed, considered to be more useful when it is developed with 5-point scale rather than 2.

근시(近視)의 침·지압 치료에 관한 고찰 - 한국어권, 영어권, 중국어권을 중심으로 -

문혜연,천진홍,김기봉,Moon, Hye Yeon,Cheon, Jin Hong,Kim, Ki Bong 대한한방소아과학회 2013 대한한방소아과학회지 Vol.27 No.4

Objectives The purpose of this study is to obtain knowledge and views on treatment of acupuncture and acupressure for myopia. Methods The key words such as 'myopia, acupuncture', 'myopia, acupressure', 'refractive errors, acupuncture', 'refractive errors, acupressure' are used for the research through PubMed. Total 13 studies among the searched 66 were analyzed, except duplicated studies and have little relation to myopia or acupuncture and acupressure. Results Total 13 studies were selected: RCT (5), NRCT (3), UCT (3), Review (2). RCT had two studies on treatment by stimulating auricular acupoints, one study on a treatment by stimulating auricular acupoints and meridian acupoints, one study on a treatment to stimulate auricular acupoints with medication, and one study on electroacupuncture. In NRCT, two studies were on treatment to stimulate auricular acupoints with medication and only one study was on analysis of effect according to intensity of acupuncture. UCT had two studies on acupuncture, and one study on treatment to stimulate auricular acupoints. In Review, there were one study on introduction of Chinese eye exercises, and one study on systematic review for effectiveness and safety of acupuncture. Conclusions The effect on treatment of acupuncture and acupressure for myopia had mostly positive results. However, still not many researches were done to conclude this found. Also, the design of the experiment should be more accurate with systematically designed experimental group and control group.

문헌 고찰을 통한 비만 치료 한약의 장내미생물 변화 연구

김승원,천진홍,김기봉,Kim, Seung Won,Cheon, Jin Hong,Kim, Ki Bong 대한한방소아과학회 2022 대한한방소아과학회지 Vol.36 No.2

Objective This study identified useful herbal medicines and prescriptions for obesity treatment by analyzing herbal medicines and prescriptions that showed meaningful results in weight loss by changing the gut microbiota. Methods Using PubMed, we selected and studied 23 papers showing meaningful results on weight loss through changes in the gut microbiota using herbal medicines. Result Of the 23 selected papers, 17 were of studies using herbal medicines, and 6 of studies using prescriptions. Pomegranate peel, Flos Lonicera, Rehmannia glutinosa, Rhein, Coix seed, Platycodon grandiflorus, mulberry leaves, Poria cocos, asperuloside, Bupleuri radix, Astragalus polysaccharides, Ephedra sinica, Ganoderma lucidum, Hirsutella sinensis, Caulis spatholobi, aconite, and Bletilla striata were used as herbal medicine. Linggui zhugan-tang, Bofutsushosan, Shenling baizhu powder, Chowiseungcheng-tang, Daesiho-tang, and Yijin-tang were used as prescription. Conclusion Seventeen herbal medicines and six prescriptions associated with meaningful results in weight loss through changes in the gut microbiota, suggest the possibility of treatment and prevention of obesity through herbal medicine.

하태독법의 최신 연구 동향

주현주,천진홍,김기봉,Ju, Hyun Ju,Cheon, Jin Hong,Kim, Ki Bong 대한한방소아과학회 2020 대한한방소아과학회지 Vol.34 No.4

Objectives The purpose of this study is to perform a review on recent researches of Hataedock, a traditional method of removing fetal toxin by dropping herbal extracts in the mouth, to appraise its preventive and therapeutic effects of diseases. Methods Studies of Hataedock were extracted from both Chinese and Korean medical journals published within 10 years, from January 2010 to January 2020. Clinical studies and experimental researches were analyzed and categorized to skin disease, allergic rhinitis, intestinal mucosa inflammation and anal fistula for further evaluation. Results Among 194 studies were searched and screened, 22 met designated criteria. Hataedock showed the effectiveness in treating skin disease, allergic rhinitis, intestinal mucosa inflammation and anal fistula by maintaining skin barrier and regulating immune system. Coptis japonica, Glycyrrhiza uralensis, and Fermented Glycine max were mainly used as herbal extracts in Hataedock. Conclusion This study shows the recent research trends of Hataedock and suggests that Hataedock can be considered as a method of treatment or prevention to some of the incurable chronic diseases.

자금정의 아토피피부염 치료 효과에 대한 환자군 연구

박인우,김희연,천진홍,사은호,사복석,김기봉,Park, In Woo,Kim, Hee Yun,Cheon, Jin Hong,Shih, Yin-hao,Sah, Bok Seok,Kim, Ki Bong 대한한방소아과학회 2018 대한한방소아과학회지 Vol.32 No.1

Objectives The purpose of this study is to analyze the clinical data of atopic dermatitis patients and to report the therapeutic effect of Jageum-Jung. Methods We conducted a retrospective study on the effects of treatment on atopic dermatitis patients who took Jageum-Jung from August 1, 2017 to December 20, 2017. The patients visited three times during the treatment period. The SCORAD Index score was measured and analyzed. Results Atopic dermatitis patients were 2 adults and 5 children. Both 2 adults were male (100%). Among the children, 1 child was a male (20%) and 4 children were females (80%). For adults, average age was 29.5 years, average weight was 72.75 kg, average height was 1.76 m and average BMI was $23.49kg/m^2$. For children, average age was 6.2 years, average weight was 23.92 kg, average height was 1.2 m and average BMI was $16.08kg/m^2$. The atopic dermatitis patients' average SCORAD Index score was 18.04 at first visit, 11.46 at second visit, and 7.64 at third visit. The scores lowered significantly after every visit. Conclusions The SCORAD Index in atopic dermatitis patients who took Jageum-Jung significantly decreased and it is expected that Jageum-Jung will be clinically effective in the treatment of atopic dermatitis.