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천문우(Moon Woo Chun),김중협(Joong Hyup Kim),와따나베 에이 쿄오이치(Kyoichi A. Watanabe) 대한약학회 1991 약학회지 Vol.35 No.6
The synthetic methodologies for the preparation of C-nucleosides are divided into four categories, and each category is discussed in details. The chemical reactions which lead to other C-nucleosides from preformed the natural product pseudouridine are described first, followed by synthesis of C-nucleosides by condensation of pre-formed heterocyclic base with sugar, and by construction of heterocyclic base from a carbohydrate intermediate that bear functional carbon fragment at the anomeric position. Finally, methods of total synthesis of C-nucleosides from carbohydrate and achiral starting materials are presented.
천문우,김문환,Chun, Moon-Woo,Kim, Moon-Hwan 대한약학회 1988 약학회지 Vol.32 No.3
Methyl 6-0-benzoyl-3-0-benzyl-2, 5-di-deoxy-2-fluoro-allofuranose (11) and 1, 2-0-di-acetyl-6-0-benzoyl-3, 5-di-deoxy-3-fluoro-glucofuranoes (22), sugar moieties of potential antiviral and/or anticancer chemotherapeutic nucleoside, were synthesized from D-glucose.
채동규,천문우,채건,Chae, Dong-Kyu,Chun, Moon-Woo,Chae, Kun 대한약학회 1969 약학회지 Vol.13 No.4
In order to diminish the side effects of nitrogen mustard on cancertherapy, alkyl and heterocyclic radicals were introduced to nitrogen mustard base. The prepared new nitrogen mustard derivtives are N-bis($\beta$-chloroethyl)-2-furamide, 5-nitro-N-bis($\beta$-chloroethyl)-2-furamide and N-bis($\beta$-chloroethyl) ortamide hydrochloride.
Acyclonucleoside 류의 합성(3) -Ribavirin 유도체의 합성-
문형룡(Hyung Ryong Moon),양재욱(Jae Wook Yang),김문환(Moon Hwan Kim),천문우(Moon Woo Chun),정원근(Won Keun Chung) 대한약학회 1989 약학회지 Vol.33 No.6
The Synthesis of acyclic derivatives of ribavirin (2''-azido and halo seco derivatives) for the development of new antiviral agents is described. These acyclic nucleosides are synthesized from ribavirin by the method of ring opening reaction of sugar moietry.
인돌 유도체의 Pseudohalogen 화 및 Halogen 화 반응에 관한 연구(II) 인돌의 Azido 및 Thiocyanato 유도체의 새로운 합성법
채동규(Dong Kyu Chae),천문우(Moon Woo Chun),조재천(Jae Chun Jo) 대한약학회 1979 약학회지 Vol.23 No.3,4
A new method for the synthesis of azido and thiocyanatoindoles by iodine and sodium azide or sodium thiocyanate in acetonitile at room temperature or 60oC was found. Azidoindoles (3-azido-3-methyl-2-phenylindolenine, 3-azido-2, 3-diphenylindolenine, 2-azidomethyl-3-methylindole and I-azido-1, 2, 3, 4-tetrahyrocarbazole) and thiocyanatoindoles(3-thiocyanatoindole, 2-phenyl-3-thiocyanato indole, 3-methyl-2-phenyl-6-thiocyanatoindole and 2, 3-diphenyl-6-thiocyanatoindole) were prepared by this method in good yields.
D-1,3-디옥솔란 및 L-1,3-옥사티올란 5-페닐세레닐 피리미딘 뉴크레오사이드의 합성
유정만(Jung Man Yoo),문현주(Hyun Joo Moon),정병호(Byung Ho Chung),최보길(Bo Gil Choi),홍준희(Joong Hee Hong),천문우(Moon Woo Chun) 대한약학회 1996 약학회지 Vol.40 No.1
Eight new D-1.3-dioxolanyl and L-1,3-oxathiolanyl nucleosides containing 5-phenyl- selenyl pyrimidine bases which are expected to have antiviral activity were synthesized. Condensation of D-1,3-dioxolane acetate and L-1,3-oxathiolane acetate with 5-phenylselenyl pyrimidines gave anomeric mixtures of their nucleosides which were separated by silicagel column chromatography.
제암성물질의 합성 및 항종양시험에 관한 연구III. 수종한국산식물의 Ethanol Extract의 항종양시험
정보섭(Bo Sup Chung),정원근(Won Keun Chung),김중협(Choong Hyp Kim),천문우(Moon Woo Chun) 대한약학회 1970 약학회지 Vol.14 No.3,4
Alcohol extracts of six plant namely Coix agrestis L>OUREIRO, Chloranthus Japonicus (Siebi) NAKAI, Ajuga Spectabilis NAKAI, Juglans mandsuria Max,, Cirsium Macki var Ussuriense KITA and Sasamorpha Purpurascense (Hack) NAKAI were subjected to the screening tests for anti-tumor activities against SN-36 Leukemia, Sarcoma 180 and Ehrlich ascites carcinoma. Of the six extracts, Ajuga Spectabilis NAKAI and Coix agrestis LOUREIRO were found to be potential in survival effect of tumor transplanted mice.
Acyclonucleoside 류의 합성(2) -2'',3''-disubstituted secouridine의 합성-
양재욱(Jae Wook Yang),홍경애(Kyong Aie Hong),한효경(Hyo Kyung Han),천문우(Moon Woo Chun),정원근(Won keun Chung) 대한약학회 1989 약학회지 Vol.33 No.5
The synthetic study of 2'',3''-diazido and difluoro secouridines toward development of new antiviral agents is described. These acyclic nucleosides were synthesized from uridine by the method of ring opening reaction of sugar moiety.
Acyclonucleoside류의 합성(7) - 6-아자유리딘의 2'', 3''-seco유도체의 합성 -
신대홍(Dae Hong Shin),양재욱(Jae Wook Yang),김중협(Joong Hyup Kim),정원근(Won Keun Chung),천문우(Moon Woo Chun) 대한약학회 1992 약학회지 Vol.36 No.6
Synthesis of 6-aza-2''-azido-2'', 3''-secouridine, 6-aza-2'', 3''-diazido-2'', 3''-secouridine, and 6-aza-5''-azido-2'', 3''-secouridine as potential antiviral agents is described. These acyclic nucleosides were synthesized from uridine by the method of ring opening reaction of sugar moiety. And these compounds were tested against HSV-1 and HSV-2, but the in vitro test results of these compounds were negative.
정병호(Byung Ho Chung),조원제(Won Jea Cho),천승훈(Seung Hoon Cheon),박면지(Myun Ji Park),유진철(Jin Cheol Yoo),천문우(Moon Woo Chun) 대한약학회 1997 약학회지 Vol.41 No.2
For the development of antifungal agents, modification of naftifine which exhibits significant antimycotic activity was performed by replacing the naphthalene ring of it to hetero cyclic rings such as morpholine. benzothiazole, piperidine and pyridine derivatives. The synthesized compounds were tested in vitro antifungal activity against five different fungi with naftifine as a comparative antimycotic molecule. From the biological evaluation two compounds, (E)-N-(3-phenyl-2-propenyl)-N-(4-piperidinylmethyl)amine(3d) and (E)-N-(3-phenyl-2-propenyl)-N-(3-pyridylmethyl)amine(3f) showed relatively noticeable activity(MIC=50mcg/ml). On the other hand, the other compounds had no activity.