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Loxoprofen sodium 플라스타의 소염 , 진통 작용 및 혈중 약물 농도에 대한 연구
채주병(Joo Byung Chae),전홍렬(Hong Ryeol Jeon),이승목(Seung Mok Lee),정남주(Nam Joo Jeong),김수균(Soo Kyun Kim),조길도(Kil Do Cho),김동연(Dong Yeun Kim) 한국응용약물학회 1999 Biomolecules & Therapeutics(구 응용약물학회지) Vol.7 No.2
Loxoprofen-Na (sodium 2-[4-(2-oxocyclopentylmethyl)phenyl]propionate dihydrate) is a potent analgesic drug. We developed loxoprofen-Na plasters to extend duration time of analgesic activity and to reduce side effect on gastrointestinal tract. Analgesic effect of Loxoprofen-Na plasters was investigated. Loxoprofen-Na plaster had good analgesic effect in rat paw pressure test, Tail-flick latency test and acetic acid-induced writhing test. Also, it had anti-inflammatory effect on carrageenan-induced rat hind paw edema. In pharmacokinetic study of Loxoprofen-Na, plasters dosage form showed that plasma drug concentration was prolonged up to 14 hours. So, we can conclude that loxoprofen-Na plasters, when applied on skin, will he a new type of drug for controlling the various local pain or inflammation.