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5 , 15 - diHETE 의 주요 생합성 경로 : 아리키돈산으로부터 15 - HPETE를 거쳐 5 , 15 - diHETE로의 전환과정
석대은,찰스죤시 ( Dai Eun Sok,Charles J . Sih ) 생화학분자생물학회 1988 BMB Reports Vol.21 No.4
In both RBL-1 cells and human leukocytes, the calcium ionophore A 23187 enhanced the conversion of 15(S)-hydroxy-5,8,11-cis-13-trans-icosatetraenoic acid (15-HETE) to 5,15-diHETE by Ca^(++)-dependent 5-lipoxygenase (5-LPO). Interestingly, the amount of 5,15-diHETE formed from the incubation of 15(S)-hydroperoxy-5,8,11-cis-13-trans-icosatetraenoic acid (15-HPETE) with RBL-1 cells was similar to that generated from the incubation of 15-HETE with RBL-1 cells in the presence of A23187, suggesting that the 5-LPO-catalyzed conversion of 15-HPETE into 5,15-diHETE is independent of calcium ion. As a precursorial substrate for transformation to 5,15-diHETE in human leukocytes, 15-HPETE was found to be three times more efficient than 5-HPETE (5-hydroperoxy-6-trans-8,11,14-cis-icosatetraenoic acid). When 15-HETE, a strong inhibitor of lipoxygenation of arachidonic acid at C-5 or C-12, was added to the leukocytes suspension containing arachidonic acid and A 23187, the formation of 5,15-diHETE from arachidonic acid was increased to a great extent ($gt;3 times). Thus, the formation of 5,15-diHETE from arachidonic acid via 15-HPETE, which is Ca^(++)-independent and insensitive to 15-HETE, is supposed to be the more favorable pathway for the biosynthesis of 5,15-diHETE in the intact cells.
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