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Nonionic Oil-in-Water Type Cream제조 공정의 Low-Energy Emulsification에 관한 연구
차돈규,이광표 중앙대학교 약학연구소 1987 약학 논총 Vol.1 No.-
Low-Energy Emulification, an emulsification technique proposed by Lin to cut down mechanical and tehrmal energies in the process of emulsions, was examined in terms of emulsion quality and compared with the similar emulsion made with a conventional hot process. Experimental data obtained from skin care formulation consisting of oil-in-water emulsion stabilized with the nonionic surfactant indicate that the technique is extremely flexible and is capable of producing emulsions with varying droplet sizes. The key to success in applying the techniqe lies in understanding and controlling the physical variables responsible for causing a droplet size variation. The key variables found to produce physicochemically stable emulsions were: first stage emulsification temperature, mixing intensity, ratio of external phase added during the first stage of emulsification to that of second stage dilution, rate and the mode of phase combination. By effectively controlling these variables, it has been demonstrated that it is possible to produce emulsion with smaller and more uniform droplet size distribution using the low-energy technique than similar emulsion obtained with the conventional hot emulsification. Holding a large amount of external phase for the addition of α phase to the concentrate resulted in a substantial reduction of not only thermal and mechanical energies but also processing time.
김승인,류장하,차돈규 한국약제학회 1983 Journal of Pharmaceutical Investigation Vol.13 No.1
Fenbufen은 비스테로이드성 진통, 항염약물로써 경구로 투여되어 통증 및 염증제거에 효과를 나타내며 난용성인 물질이다. Fenbufen의 용해도를 증가시키기 위하여 fenbufen과 lysine을 결합시켜 fenbufen·lysine를 얻고 이를 원소분석, IR, DSC, NHR등으로 확인하였다. Fenbufen·lysine의 pH에 따른 용해도 및 용출율과 acetic acid에 의한 진통작용 및 carrageenin 족척부종법에 의한 항염작용을 검토하였다.