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Pendant Crown Ethers 운반체를 이용한 에멀젼 액체막계에서의 Pb^2+ 분리
이종광,이부영,김종향,조문환 慶尙大學校 기초과학연구소 1992 基礎科學硏究所報 Vol.8 No.-
Acryloyl methyl benzo-18-crown-6 단위체는 '4-hydroxymethyl benzo-18-crown-6와 acryloyl chloride을 반응시켜 합성하였다. Poly(acryloyl methyl benzo-18-crown-6)는 벤젠용매하에서 AIBN을 개시제로하여 제조하였다. [0.001mole/L M(NO_3)_n(M^2+ =Na^+, Mg^2+, Ca^2+, Sr^2+, Ba^2+, Zn^2+, Cu^2+, Cd^2+, Mn^n+ 와 Pb^2+)]를 포함한 source phase와 거대고리 리간드 [acryloyl methyl benzo-18-crown-6와 poly(acryloyl methyl benzo-18-crown-6)]와 계면활성제 Span 80을 포함한 toluene 막 그리고 Li_4P_2O_7를 포함하는 receiving phase로 구성되어진 에멀젼 액체막계에서 source phase로 부터 금속이온들의 소멸속도를 연구하였다. 금속이온의 이동에 관한 실험에서, 각 혼합물로 부터 Pb^2+ 이온이 가장 높은 이동율을 나타내었다. Acryloyl methyl benzo-18-crown-6 was synthesized by reacting 4'-hydroxymethyl benzo-18-crown-6 with acryloyl chloride. Poly(acryolyl methyl benzo-18-crown-6) was prepared in benzene by using AIBN as an initiator. The disapperance of metal ions from source phase as a function of time was studied in emulsion liquid membrane systems comprised in an aqueous source phase [0.001mole/L M(NO_3)_n(M^n+ =Na^+, Mg^2+, Ca^2+, Sr^2+, Ba^2+, Zn^2+, Cu^2+, Cd^2+, Mn^2+ 와 Pb^2+)], a toluene membrane containing of the macrocyclic ligand[acryloyl methyl benzo-18-crown-6 and poly(acryloyl methyl benzo-18-crown-6)] and the surfactant Span 80, and an aqueous Li_4P_2O_7 receiving phase. In the experiment for metal ions transport using this emulsioning liquid membrane, the Pb^2+ ion transport was more higher than other metal ions.
백서에서 진통과 금단증상에 미치는 Enkephalinase Inhibitor의 영향
곽기철,조문환,김기원,채수완,조규박 의과학연구소 1991 全北醫大論文集 Vol.15 No.3
Analgesic effect and influence of 2 enkephalinase inhibitors, thiorphan and N-carboxyl-Phe Leu(CMPL) on the analgesia induced by centrally administered Leu-enkephalin, B-endorphin or morphine, and their influences on the withdrawal signs in chronic morphine-dependent rats were examined. Intracerebroventricular administration of thiorphan and CMPL induced short-lasting analgesia in a dose dependent manner, whereas CMPL was 3.5 time more potent than phiorphan. these analgesic effects were attrnuated by preteatment with naloxone. Subanalgesic doses of yhese inhibitors significantly enhanced the analgesic effect of :eu-enkephalin or B-endorphine However, neither of these inhibitors affecyed the analgrsic effect morphine. In chronic morphine-dependent rats, intraventricular thiorphan or CMPL significantly attenuated naxone-precipitated jumping, diarrhea, ptosis and teeth chattering, while wet-dog shaking sign was unaltered and penile licking sign was increased. These results showed that enkephalinase inhibitors can produce analgesia by themselves and that they can enchance the analgesic effects of ensogenous opioids. these data also suggest that enkephalinase inhibitors might be useful in attenuating opiate withdrawal symptoms.