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조금철,이기형,윤충 慶熙大學校 1983 論文集 Vol.12 No.-
A total 168 cases of mortality in surgical department were reviewed during January 1978 to December 1982. The result were as follows: 1) Male out-numbered female by ratio of 1.9 to 1. The most high mortality group was in the geriatric patient, over 60 years (28%) and the least was teenagers (1.2%). 2) The hospital mortality rate was 1.86% and the postoperative mortality rate was 1.28% among the total hospitalized patients in surgical ward. The emergency operative mortality rate was 3.3 times higher than the elective one. 3) 60% of deaths occurred after 7 days of operation in selective surgical cases and 32.8% of deaths within 24 hours of operation in emergency operation cases. 4) The underlying diseases of death in surgical patients were non-neoplastic in 116 (69.1%) and neoplastic diseases in 52 cases (30.9%). In 116 cases of non-neoplastic diseases, the leading cause of death was burin in 28 (24.1%) and in malignant neoplasm, stomach cancer in 21 cases (40.4%). 5) Sepsis was the most common direct cause of death in non-neoplastic cases (48.3%) and multiple organ failure and cachexia in neoplastic patients (38.5%).
수축된 콜라겐 격자와 배양된 각질형성세포를 이용한 피부 대용물질의 제조에 관한 연구
박재경,조금철,박호철,Park, Jae-Gyeong,Jo, Geum-Cheol,Park, Ho-Cheol 대한의용생체공학회 1993 의공학회지 Vol.14 No.1
An experimental study was performed for the preparation of living skin-equivalent by the using collagen gel contraction with human fibroblasts as neodermls and cultured human keratinocytes as neoderm is . The results were as follows ; 1) The rate of collagen gel contraction was dependent on the number of fibroblasts into the lattice and collagen contraction was progressed according to the increment of the number of the cells. 2) The rate of collagen gel contraction was progressed according to the decrement of the contraction of the collagen. 3) The rate of gel contraction was progressed according to the increment of serum concentration in the fixed concentration of the fibroblasts and collagen. 4) The lattice contraction was decreased according to the increment of the population doublings of the fibroblasts. 5) Macroscopically, the artificial dermis was gray white in color and tissue-like consistency and elas- ticity. 6) Microscopically, three dimensionally contracted artificial dermis showed more dense fibroblasts and its newly formed collagen fibrils in the matrix than one dimensionally contracted one. 7) Finally prepared skin-equivalent showed good attachment of living stratified keratinocytes to the dermal equivalent microscopically. It has been proposed that newly formed skin-equivalent is suitable for the graft of extensively and deeply burned patients. Shortening of the manufacturing period of skin-equivalent and development of conservation technique as a readily usable state are to be solved for our ongoing works.