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정주원 ( Ju Won Jung ),오선경 ( Sun Kyung Oh ),최영민 ( Young Min Choi ) 서울대학교 인구의학연구소 2010 人口醫學硏究論集 Vol.23 No.-
Amniotic fluid cells are used for prenatal diagnosis of fetal abnormalities caused by genetic mutations. But the well established usage of human amniotic fluid cells in routine prenatal diagnosis and the current knowledge about origin and properties of these cells are still limited. Recently, amniotic fluid cells provide evidence that may represent new sources for human stem cells with the potential of differentiation into different cell type. It could be hopeful for patients to use human amniotic fluid cells with the stem cell properties for new cell-based therapy without the ethical problems involved in the application of human embryonic stem cells.
60대 중고령자들의 주관적 노후인식과 주관적 삶의 만족도에 관한 연구
정주원(Joo Won Jung),송현주(Hyun Ju Song) 한국노인복지학회 2012 노인복지연구 Vol.0 No.57
본 연구는 노년기의 노후시기 도래를 예측하고 이해함에 도움을 주고, 보다 체계적인 노후보장 설계를 통해 삶의 만족도를 향상시키고자 함에 그 의미가 있다. 이를 위해, 국민노후보장패널 3차년도 자료를 사용하여 60대 중고령자들의 주관적 노후 인식 여부에 영향을 미치는 요인들을 파악하고, 주관적 노후 인식에 따른 비노후 집단과 노후 집단의 주관적인 삶의 만족도와 그 영향요인을 살펴보았다. 연구결과, 60대 중고령자들의 주관적 노후 인식 여부는 개인환경적 특성과 경제상황적 특성에 따라 다르게 나타남으로써, 노후에 대한 인식이 특정 연령이나 사회적으로 합의된 기준에 의해 비롯된다기보다 개인이 처한 상황에 의해 영향을 받고 있음이 나타났다. 그리고 주관적 노후 인식 여부에 따른 주관적 삶의 만족도의 결과에서는 개인환경적 특성과 경제상황적 특성 모두에서 주관적으로 노후라고 여기지 않는 집단이 노후라고 생각하는 집단에 비해 삶의 만족도가 높게 나타났다. 각 집단별 삶의 만족도의 영향요인으로는 비노후 집단에서 연령과 가구지출이, 노후 집단에서 교육수준과 공적 연금 수급 여부가 영향을 미치는 것으로 나타났다. 이를 통해 노년기 삶의 만족도를 향상시킬 수 있는 보다 실질적인 설계를 위해서 주관적 노후인식의 중요성이 제기되었다.
정주원 ( Joo Won Jung ),강민주 ( Min Ju Kang ) 미래유아교육학회 2015 미래유아교육학회지 Vol.22 No.2
본 연구에서는 만 4세 유아의 마음이론과 도덕적 판단의 발달 수준에 대해 살펴보고 마음이론과 도덕적 판단의 관계에 대해 알아보고자 하였다. 이를 위해 만 4세 유아 117명을 대상으로 내용교체과제와 위치이동 과제를 실시하였고, 과실, 거짓말, 훔치기 항목에 대한 도덕적 판단을 근거로 한 의 도성 판단 지수를 사용하여 유아의 도덕적 판단 능력을 측정하였다. 본 연구의 결과를 요약하면 다음과 같다. 첫째, 과반수의 만 4세 유아들이 마음이론 두 과제의 개념을 이해하는 것으로 나타났다. 만4세 유아는 자신의 틀린 믿음에 대한 표상을 타인의 틀린 믿음에 대한 표상보다 잘 하는 것으로 나타났으며, 타인의 틀린 믿음에 대한 표상을 타인의 후속행동에 대한 예측보다 잘 하는 것으로 나타났다. 둘째, 만 4세 유아들은 도덕적 판단을 할 때 의도와 결과를 같은 비중으로 중요하게 고려하는 것으로 나타났다. 셋째, 유아의 마음이론과 도덕적 판단은 정적 상관이 있었다. 즉, 틀린 믿음 표상능력이 높을수록 높은 수준의 도덕적 판단을 보이는 것으로 나타났다. 본 연구는 도덕성 발달에 관련된 변인을 밝힘으로써 도덕 교육 프로그램 개발을 위한 기초자료를 제공하였다는데 의의가 있다. The purpose of this study was to investigate the relationship between Theory of Mind and the moral judgment among Korean preschoolers. Participants in this study were 117 children(59boys, 59girls). Theory of Mind was assessed by the unexpected content task and the unexpected location task. Children`s moral judgment was measured by story pairs of clumsiness, lying, and stealing, then the Intention Judgment Quotient was calculated. The results of this study were as follows: First, more than half of 4-year-olds were observed to have the concept of the Theory of Mind. In general, the 4-year-olds understood their own false-belief better than the other`s false-belief, and understood the other`s false-belief better than predicting the main character`s action in the story. Second, when the 4-year-olds were in the situation of judging the main character`s morality, they considered the main character`s intention and the results with almost identical weight. Third, children`s Theory of Mind and moral judgement were positively correlated. Thus, children who have a good understanding of Theory of Mind tended to have more mature level of judgment regarding the moral issues. This study provided the factor related to the moral development that would have an implication in developing the moral development program for young children.
임상 적용을 위한 인간 배아줄기세포 배양 환경에 관한 연구 동향
정주원 ( Ju Won Jung ),설혜원 ( Hye Won Seol ),최영민 ( Young Min Choi ) 서울대학교 인구의학연구소 2015 人口醫學硏究論集 Vol.28 No.-
Human embryonic stem cells are great resources for cell based therapies and clinical application in regenerative medicine. In this review, we summarize recent developments of culture conditions, including growth medium, extracellular matrix components, physiological environments and maintenance methods in human embryonic stem cells for clinical trials. Based on the researches up to now in human embryonic stem cell culture conditions, the studies should be continued and investigated advances being toward new clinical-grade xeno-free culture systems. Ultimately, it will be more effective production of clinical-grade human embryonic stem cells to useful therapeutic applications in the future.
세계 각국의 인간 배아줄기세포주 분석 및 이용 연구 현황
정주원 ( Ju Won Jung ),오선경 ( Sun Kyung Oh ),최영민 ( Young Min Choi ) 서울대학교 인구의학연구소 2012 人口醫學硏究論集 Vol.25 No.-
Currently, human pluripotent stem cells (hPSCs), including human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs), are one of the most aggressive and brilliant research sources. In this study, we review data on hESC research papers published between 1998-2010. We analyzed the number of established hESC lines and experimental work using bESCs, and extended the analysis to the use of specific cell lines in international hESC researches. We con6rmed the predominance of use of a few hESC tines (H 1 and H9) in hESC research, however, international stem cell research groups use various hESC lines.
인간 배아줄기세포의 동결에 이용되는 동결방지제에 대한 연구
정주원 ( Ju Won Jung ),오선경 ( Sun Kyung Oh ),최영민 ( Young Min Choi ) 서울대학교 인구의학연구소 2013 人口醫學硏究論集 Vol.26 No.-
Human embryonic stem cells (hESCs) are a great cell source for regenerative medicine including cell based therapy and drug development in clinical purposes. But hESCs could have low survival rates and reduced differentiation potential caused by high sensitivity during cryopreservation. Dimethyl sulfoxide (DMSO) is most commonly used as cryoprotectant agents for cell cryopreservation. Such cryoprotectant agents prevent cell damage during the freezing process and improve cell recovery after freezing-thawing. However, DMSO as a cryoprotectant is cytotoxic. In this review, we discussed cryoprectant agents and methods for effective cryopreservation of hESCs.
인간 배아줄기세포 임상적용을 위한 배양환경으로서 feeder-free 및 xeno-free 조건에 대한 연구 동향
정주원 ( Ju Won Jung ),오선경 ( Sun Kyung Oh ),최영민 ( Young Min Choi ) 서울대학교 인구의학연구소 2011 人口醫學硏究論集 Vol.24 No.-
The developmental potential of human embryonic stem cells (hESCs) makes them an useful tool in clinical research and important role in the future of regenerative medicine. Because traditional hESC culture systems have been relied on animal derived products and mouse feeder layers, they can cause expose to potential immunogenicity and contamination with pathogens. For clinical applications, hESCs must be cultured in chemically defined, xeno-free culture systems that support self renewal and directed differentiation. We reviewed methods for establishment and efficient propagation of hESCs under feeder-free and xeno-free culture conditions for cell therapy applications.
납 취급 근로자의 Monte-Carlo simulation을 이용한 노출 및 건강위해성평가
염정호 ( Jung Ho Youm ),권근상 ( Keun Sang Kwon ),이주형 ( Ju Hyoung Lee ),정주원 ( Joo Won Jeong ) 한국산업위생학회 2006 한국산업보건학회지 Vol.16 No.2
Objective: This study was conducted to quantify chronic lead exposure from various media(ie. working environment, food, ambient air), and to certify the usefulness of exposure assessment using Monte-Carlo simulation in the fields of occupational health. Methods: Data were obtained from Korean Industrial Health Association, Korea Food and Drug Administration, and the Ministry of Environment. Then lead worker`s exposure was estimated indirectly from various media and parameters (ie. volume inhaled, body weight, dietary intake, etc.). Uncertainty was analyzed by Monte Carlo simulation with Crystal Ball software. Exposure doses and hazard indices were simulated with various hypothetical scenarios including weekly working hours and respiratory protective equipment. Results: Without respiratory protective equipment, the total exposure dose per kilogram of body weight of lead workers was estimated as 5.45×10(-3) mg/kg/day, and hazard index was estimated as 2.26, and exposure contributions were calculated as follows: working environment(82.42%); foods(17.57%); and ambient air(0.01%). But, if working condition has changed-reduction of working hours and using respiratory protective equipment, the total exposure dose per kilogram of body weight was estimated between 1.34×10(-3)-1.49×10(-3) mg/kg/day, and hazard index was estimated between 0.56-0.62. Conclusions: This study suggested that occurrence of hazardous impact(ie. increased blood pressure) through lifetime lead exposure would be expected, and that the Monte-Carlo simulation was useful for the fields of occupational health.