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Glutaminase 저해 항암제 개발의 최근 발전 사항들
김규비(Gyubi Kim),주한솔(Hansol Joo),정종화(Jong-Wha Jung) 대한약학회 2021 약학회지 Vol.65 No.5
Glutaminolysis is closely related to uncontrolled tumor growth and metastasis in various glutamine-dependent cancers. As such, rewiring cancer metabolism using a glutaminolysis intervention has attracted much attention with recent progress in developing glutaminase inhibitors as anticancer agents. This review paper described the current understanding of glutaminases and their roles in cancers and small-molecule glutaminase inhibitors. In particular, recent developments of natural and synthetic glutaminase inhibitors were covered, focusing on their binding sites and isoform selectivity and briefly, on their structure-activity relationship. Some of the glutaminase inhibitors are in clinical trials, and if successful, it would lead to novel pharmacological intervention to effectively treat cancers.
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정혜웅(Hye Ung Jeong),오창민(Changmin Oh),진효언(Hyo-Eon Jin),정종화(Jong-Wha Jung) 대한약학회 2024 약학회지 Vol.68 No.2
Peptide drugs generally show high performance in terms of safety, target affinity, and efficacy, but have limitations such as low bioavailability and short half-life. To improve this, new synthetic and analytical techniques have been developed, and the global market for peptide drugs has made great strides in the past few years, with novel peptide drugs being applied to multiple therapeutic areas. In line with this trend, 5 out of 55 new molecular entities (NMEs) approved by the FDA in the year 2023 were peptide drugs, which is an increasing trend in the last few years. In this review article, we will discuss the mechanisms of action and clinical indications, chemical structure and design, and pharmacokinetic perspectives of 6 FDA-approved peptide drugs in 2023 including 5 NMEs.
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