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술전 및 술후 항암제 요법이 백서 배부 창상 치유에 미치는 영향
민병국(Byoung Kook Min),정인교(In Koo Chung) 대한구강악안면외과학회 1990 대한구강악안면외과학회지 Vol.16 No.4
This study undertaken to observe the effects of methotrexate and 5-fluorouracil on the healing of surgical wound in the white rats of Sprague-Dawley strain. A total of sixty-four rats weighing about 200 gm were used through this experiment. Experimental animals were divided into one control group (8 rats) and two experimental groups (56 rats) of MTX group and 5-FU group which were administrated 2.5 ㎎ methotrexate and 200 ㎎ 5-fluorouracil per kilogram body weight with single dose respectively. And the each experimental group was subdivided into seven groups. In group 1, 2, 3, intramuscular injection of MTX and intraperitoneal injection of 5-FU were performed on 3, 2, 1 weeks after incision. In group 4, 5, 6, 7, incision and suture were performed on 1, 2, 3, 4 weeks after administration of anticancer drugs. Thereafter, rats were serially sacrificed in 1st, 3rd, 7th, 14th day after injection of antineoplastic agents (gr. 1, 2, 3) and incision (gr. 4, 5, 6, 7). The specimens were obtained and processed in a routine manner for Hematoxylin-Eosin stain. After microscopic examination, following results were obtained. 1. In group 1, 2, 3, the healing process was not affected by anticancer drug. 2. In group 4, the healing was delayed about 7 days than that of control group. The delayed healing time due to effect of 5-FU was more significant than in the group of methotrexate administration. 3. In group 5, 6, 7, the healing process was not affected by anticancer drug, but proliferation of fibroblasts and collagen laydown were decreased.
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비인강 혈관 섬유종(Nasopharyngeal Angiofibroma)의 증례보고
양동규(Yang Dong Kyu),정인교(Chung In Koo),최창수(Tchoi Tchang Soo) 대한구강악안면외과학회 1988 대한구강악안면외과학회지 Vol.14 No.1
Nasopharyngeal angiofibroma is an uncommon benign tumor of vascular fibrotic nature, but can be dealt with clinically malignancy because of expansive growth, locally invasive tendency, anatomical relationship, severe bleeding tendency in surgical procedures and tesistance to treatment. And it is generally considered to be a lesion which occurs exclusively on adolescent male. The authors had experienced a case of nasopharyngeal angiofibroma in 9-year-old boy with severe nasal obstruction. The tumor mass had occupied posterior wall of nasopharynx and extended to the nasal cavities. The tumor mass was red or purple-colored, round & multilobulated shape & its base was pedunculated. The tumor mass was easily removed by method of transpalatal approach under general ansthesia without severe bleeding. After treatment, nasal breathing & speech was completely corrected.
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양동규(Yang Dong Kyu),정인교(Chung In Koo),박성진(Park Seong Jin),홍시형(Hong Si- Young),박영호(Park Young Ho) 대한구강악안면외과학회 1985 대한구강악안면외과학회지 Vol.11 No.2
Necrotizing Fascitis is a relatively rare but specific clinical entity characterized by extensive necrosis of the superficial fascia with widespread undermining of surrounding tissue and extreme systemic toxicity. The upper and lower extermities are most commonly affected parts, but occurance in head and neck is rare, possibly because of the abundant vascularity of the region. It s treatment require aggressive therapy, such as wide incision and drainage, repeated surgical debridement, aggressive wound care, massive antibiotic therapy, resolving of associated disease and supportive treatment. Recently, we experienced a case of Necrotizing Fasciitis in Oral & Maxillofacial region. The patient was 68 year old female and was severe depressed defensive mechanism due to multiple systemic disturbance. Pathologic lesion appeared as widespread fascial necrosis, gangrene, crepitation and skin discoloration on the right side of face and submandibular region. Local surgical wound healing was successful but on the 55 days after admission, the patient eventually died because of gastrointestinal bleeding. The author conclude that the most importance in treatment of necrotizing fasciitis is elevation of host resitance by resolving of associated systemic disorders and support of multiple vital organ.
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