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흰쥐 관절염 모델에서 족삼리와 대릉 배오 전침의 상호억제 효과
김여정 ( Yeojung Kim ),정연정 ( Yunjung Jung ),이창형 ( Chang-hyung Lee ),구성태 ( Sungtae Koo ) 경락경혈학회 2013 Korean Journal of Acupuncture Vol.30 No.4
Objectives: We examined mutual inhibitory effects of combined acupoints in arthritic pain induce by carrageenan (CA). Electroacupuncture (EA) is considered a potentially useful treatment for arthritis. Although the analgesic effect of acupuncture is well documented, little is understood about its biological basis. There are many previous studies of positive effect of combined acupoint, this study was conducted to see the mutual inhibitory effects produced by combined acupoint (ST36 and PC7) on arthritic rats. Methods: For the induction of inflammatory pain rat model, CA was injected into the knee joint cavity. There are four groups; EA was applied to bilateral PC7 acupoints(PC7 group), ST36 acupoints (ST36 group), and both PC7 and ST36 acupoints (ST36+PC7 group) except for the control group. The pain level were assessed to determine the change in weight bearing force. We also examined the COX-2 expression in dorsal horn using immunohistochemistry and western blot analysis. Results: The ST36+PC7 group data showed the significant reduction of weight bearing force and the induction of COX-2 protein expression compared with the ST36 group. Conclusions: Simultaneous EA applied to the ST36 and PC7 acupoints reduced the analgesic effect of the ST36 group on knee inflammatory pain.
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