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오줌 유래 Trypsin 억제제가 출혈성쇼크에 미치는 영향
송동호(Dong Ho Song),조명행(Myung Haing Cho),김종민(Jong Min Kim),권오경(Oh Kyeong Kweon),이희천(Hee Chon Lee),정언승(Eon Seung Chung),양한석(Han Seok Yang),변종환(Jong Hwan Byun) 한국응용약물학회 1997 Biomolecules & Therapeutics(구 응용약물학회지) Vol.5 No.3
The protective effect of human urinary trypsin inhibitor(LTI) on acute hemorrhagic shock in beagle dog was studied. Hemorrhagic shock was experimentally induced in thoracotomized beagle dogs by removing blood and maintaining low arterial blood pressure for 30 min, and then blood removed was entirely transfused back into the dogs within one hour. When the blood was transfused, UTI was administered together to check the potential protective effect of UTI on hemorrhagic shock. The arterial blood pressure recovery was accelerated slightly by UTI treatment. Blood pH and P_aco₂ returned to normal level in shorter time in the UTI treatment group. These data suggest that UTI may have protective effects on experimentally induced hemorrhagic shock.